Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Author: search.filters.author.Haberal, MehmetSubject: search.filters.subject.Aspergillus fumigatus

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    Role of Bronchoalveolar Lavage in Diagnosis of Fungal Infections in Liver Transplant Recipients
    (2015) Tepeoglu, Merih; Atilgan, Alev Ok; Ozdemir, B. Handan; Haberal, Mehmet; 0000-0002-3462-7632; 0000-0001-8595-8880; 0000-0002-7528-3557; 0000-0002-9894-8005; 25894185; AAJ-8097-2021; AAK-3333-2021; X-8540-2019; AAK-5222-2021
    Objectives: Pulmonary fungal infections remain the most important cause of morbidity and mortality in liver transplant recipients. Fast and accurate causative diagnoses are essential for a good outcome. Bronchoscopy with bronchoalveolar lavage frequently is performed to diagnose pulmonary infections in immunocompromised patients. The aim of this study was to evaluate the diagnostic use of bronchoalveolar lavage in liver transplant recipients with pulmonary infections. Materials and Methods: We retrospectively analyzed the data of 408 patients who underwent liver transplant from January 1990 to December 2012. Patients who underwent bronchoalveolar lavage after transplant were included in this study. Results: There were 18 of 408 liver transplant recipients (4.41%) who underwent bronchoalveolar lavage after transplant. The mean age was 49.5 +/- 18 years. In 5 patients (27.8%), fungal microorganisms were observed in the cytology of bronchoalveolar lavage specimens, including Aspergillus fumigatus in 3 patients and Candida albicans in 2 patients. Death occurred in 4 of 5 patients (80%) with fungal infections. No association was observed between the presence of fungal infection and clinical and radiographic findings of the patients. Conclusions: Bronchoscopy with bronchoalveolar lavage is a useful, noninvasive diagnostic tool for the rapid diagnosis of infections in solid-organ transplant recipients.
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    Radiologically Occult Invasive Pulmonary Aspergillosis in a Patient With Liver Transplant
    (2018) Esendagli, Dorina; Serifoglu, Irem; Bozbas, Serife Savas; Tepeoglu, Merih; Akcay, Sule; Haberal, Mehmet; 0000-0002-6619-2952; 0000-0002-7230-202X; 0000-0002-9894-8005; 0000-0002-8360-6459; 0000-0002-3462-7632; 29528022; ABF-9398-2020; AAS-6628-2021; AAI-8064-2021; AAK-5222-2021; AAB-5175-2021; AAJ-8097-2021
    Invasive pulmonary aspergillosis is an infection seen in patients receiving intensive immunosuppressive regimens, such as transplant recipients. Some risk factors that increase the incidence of infection have been determined, and patients defined as having high risk are recommended to take antifungal prophylaxis and be monitored closely. Here, we present a liver transplant patient with mild respiratory symptoms and a normal chest radiography on day 26 posttransplant. However, he had acute renal failure and underwent hemodialysis, which are both defined to increase significantly the risk of aspergillosis. Although the radiographic scan was initially normal, thorax tomography and later bronchoscopy showed findings compatible with pulmonary aspergillosis, and the patient was started on antifungal treatment. The nonspecific mild symptoms and an initial normal radiology can make diagnosis of invasive fungal infections difficult; thus caution and close follow-up of high-risk patients should be performed.