Tıp Fakültesi / Faculty of Medicine

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Author: search.filters.author.Guler, Ozan Cemsearch.filters.applied.f.publicationcategory: search.filters.publicationcategory.Makale - Ulusal Hakemli Dergi

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    Prognostic Role of Pretreatment Level Hemoglobin Levels in Patients with Local Advanced Rectum Cancer Treated with Preoperative Chemotherapy
    (2018) Yildirim, Berna Akkus; Sumbul, Ahmet Taner; Guler, Ozan Cem; Sedef, Ali Murat; Onal, Cem; Topkan, Erkan; https://orcid.org/0000-0001-6661-4185; https://orcid.org/0000-0002-5573-906X; https://orcid.org/0000-0001-6908-3412; https://orcid.org/0000-0001-8120-7123; V-5717-2017; D-4793-2014; AAC-5654-2020; HOC-5611-2023; AAG-2213-2021
    Purpose: This study aims to systematically evaluate the relationship between baseline blood count levels, simply and basically initiated, and treatment response in locally advanced rectal cancer patients treated with neoadjuvant chemoradiotherapy. Materials and Methods: This retrospective study included 123 locally advanced rectal cancer patients who were treated with neoadjuvant chemoradiotherapy followed by surgery. Pretreatment Hb level was assessed as an independent variable for the whole study sample. The primary endpoint was the impact of pre-treatment Hb levels on overall survival. Results: At a median follow-up of 40,3 months (1,4-92 months). A Hb cut-off value of 12.5 g/dl (AUC=0.673, %95 0.564-0.781) was identified by using ROC analysis. Following the stratification of patients at this cut-off point into two groups: normal-Hb (nHb; Hb>12) and low-Hb (dHb <= 12), the comparative survival analysis demonstrated that the patients in the nHb group had significantly increased OS than those in the dHb group, and retained its independent significant association with survival outcomes in the multivariate analysis. Conclusion: Knowledge of pretreatment hematological parameters appears to be an important prognostic factor in patients with rectal carcinoma.
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    Effect of Adjuvant Extended Temozolamide Treatment in Survival of Patients with Glioblastoma Multiforme
    (2018) Yildirim, Berna Akkus; Sumbul, Ahmet Taner; Topkan, Erkan; Ozdemir, Yurday; Besen, Ali Ayberk; Guler, Ozan Cem; Sedef, Ali Murat; Onal, Cem; https://orcid.org/0000-0001-6661-4185; https://orcid.org/0000-0002-5573-906X; https://orcid.org/0000-0001-8120-7123; https://orcid.org/0000-0002-2218-2074; https://orcid.org/0000-0002-7862-0192; V-5717-2017; D-4793-2014; AAG-2213-2021; AAG-5629-2021; AAD-6910-2021; HOC-5611-2023
    Purpose: The aim of this retrospective cohort study was to evaluate the prognostic effect extended temozolamide on survival outcomes of glioblastoma multiforme patients who were underwent surgery/biopsy followed treated with definitive chemo-radiotherapy. Materials and Methods: We retrospectively analyzed the datas of 225 patients with gliablastoma multiforme whom admitted to our clinic All patients were completed concomitant chemoradiotherapy with temozolamide and adjuvant temozolamide therapy at least for six months or more. Patients were divided into two groups as standart and extended temozolamid therapy group as using temozolamide therapy for at least 6 months or more. Results: The median follow-up of the whole patients18 (range 2-125) months, 65 patients (56%) were alive. Extended temozolamide (>6) was associated with longer survival, but was not significantly with survival outcomes in the univariate analysis (49.0 vs 68.33 months; p=0.082). However, progression free survival analysis demonstrated that the patient in extended temozolamide group had paramount extended progression free survival (14 vs 9 months) than other group in standart cycle temozolamide. Conclusion: Our study show that extended temozolamide is good tolerated and leads to a significantly increase in progression free survival and overall survival in newly diagnosed patients with glioblastoma multiforme.