Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Author: search.filters.author.Erdem, RemziHas files: No

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    Multidrug Resistance 1 (MDR1) 3435C/T Genotyping in Childhood Drug-Resistant Epilepsy
    (2014) Saygi, Semra; Alehan, Fusun; Atac, Fatma Belgin; Erol, Ilknur; Verdi, Hasibe; Erdem, Remzi; https://orcid.org/0000-0002-8522-5078; https://orcid.org/0000-0001-6868-2165; https://orcid.org/0000-0002-3530-0463; https://orcid.org/0000-0003-0591-009X; https://orcid.org/0000-0002-7537-2170; 23465586; AAB-1203-2021; ABG-9966-2020; AAK-4825-2021; ABG-9940-2020
    Introduction: A mutation at nucleotide position 3435 in exon 26 of the multidrug resistance 1 (MDR1) gene is the most frequently studied polymorphism in relation to multidrug resistance. However, there are conflicting data as to whether the CC or TT genotype of the 3435C>T polymorphism is associated with drug resistance. Methods and results: We investigated the association between this polymorphism in drug-resistant childhood epilepsy by comparison with drug-responsive patients. In total, 59 patients with drug-resistant epilepsy, defined as having four or more seizures within a 12-month period while using three or more AEDs, 60 children with drug-responsive epilepsy who had remained seizure-free for 12 months on their current AED regimen and 76 healthy children were involved in this study. Genotype frequencies in drug-resistant patients were as follows: 32.2% CC, 44.1% CT, 23.7% TT; in the drug-responsive group: 20.0% CC, 50.0% CT, 30.0% TT; in the control group: 24.3% CC, 50.0% CT, 25.7% TT. Comparison of drug-resistant and drug-responsive patients revealed no significant difference in genotype frequency. The findings of the epilepsy patients were not significantly different from those of the healthy control subjects. Conclusions: Our study does not support any significant association between the MDR1 polymorphism and drug-resistant childhood epilepsy. (C) 2013 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.
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    Technique of Ileobladder and Kidney Transplant in Rats and Pigs
    (2018) Haberal, Mehmet; Kirnap, Mahir; Gokce, Oruc N.; Bacanli, Didem; Ersoy, Zeynep; Bayzakov, Mirbek; Torgay, Adnan; Ozdemir, Handan; Erdem, Remzi; 0000-0003-0767-1088; 0000-0002-9678-7818; 0000-0002-7528-3557; 0000-0002-6829-3300; 0000-0002-3462-7632; 0000-0002-7537-2170; 29409436; AAF-3066-2021; AAH-9198-2019; AAQ-8259-2021; X-8540-2019; AAJ-5221-2021; AAJ-8097-2021
    Objectives: Kidney transplant is the best choice for treatment of patients with advanced chronic renal disease. However, small, poorly compliant, and unstable bladders can result in major problems for patients. Here, we aimed to develop and evaluate a new ileobladder model. Materials and Methods: Fifteen rats (250-300 g) and 5 pigs (similar to 100 kg) were cared for according to institutional and published guidelines. After general anesthesia, laparotomy was done through midline incision. Ileal loops were prepared for ileobladder. After cystectomy (0.5 cm above the trigone in rats, 1 cm above the trigone in pigs), anastomoses were done between antimesenteric sides of ileal loops and bladder remnant with 6/0 Prolene suture. Three other pigs received simultaneous renal transplant. Results: One rat died on day 1 postsurgery from multiorgan hemorrhage. Two rats survived for 5 days, 3 rats for 7 days, and 3 rats for 11 days; 6 rats were killed for pathologic evaluation after 3 months. One pig survived for 22 days and 1 for 9 days. Of the 3 pigs that received a simultaneous renal transplant, 2 pigs were alive and doing well 80 and 72 days after surgery with normal urinary discharge (1 pig was killed for pathologic evaluation after 3 days). When ileobladder was opened, complete recovery of the anastomosis line was observed. Pathologic examination of the anastomosis sites reported a normal healing process with moderate inflammation and the muscular wall of the intestine showed hypertrophia that nearly reached the size of the bladder muscularis propria. Conclusions: Although we had some complications because no draining procedure was used, in terms of technique, our new ileobladder model is promising for providing functional bladder volume. A larger scale series in the clinical setting is planned. This technique can be useful for small bladders and bladder physiology disorders.
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    EVALUATION OF NEW BASKENT UNIVERSITY PRESERVATION SOLUTION FOR LIVER, KIDNEY AND INTESTINE GRAFT DURING COLD ISCHEMIA: PRELIMINARY EXPERIMENTAL ANIMAL STUDY
    (2019) Haberal, Mehmet; Kirnap, Mahir; Erdem, Remzi; Ozdemir, B. Handan; Lux, K. Michael; Bacanli, Didem; AAH-9198-2019
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    EFFECT OF NEW BASKENT UNIVERSITY ORGAN-PRESERVATION SOLUTION ON THE ACTIN CYTOSKELETON REARRANGEMENT AND APOPTOSIS OF RENAL TUBULAR CELLS: COMPARISON WITH OTHER PRESERVATION SOLUTIONS
    (2019) Haberal, Mehmet; Ozdemir, B. Handan; Kirnap, Mahir; Erdem, Remzi; Lux, K. Michael; Bacanli, Didem; AAH-9198-2019