Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

Browse

Filters

2016 - 20182

Settings

Author: search.filters.author.Erbay, GurcanSubject: search.filters.subject.Diffusion-weighted imaging

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Utility of Diffusion-Weighted MRI to Detect Changes in Liver Diffusion in Benign and Malignant Distal Bile Duct Obstruction: The Influence of Choice of b-Values
    (2016) Karan, Belgin; Erbay, Gurcan; Koc, Zafer; Pourbagher, Aysin; Yildirim, Sedat; Agildere, Ahmet Muhtesem; 0000-0003-0987-1980; 0000-0002-5735-4315; 0000-0002-1706-8680; 0000-0003-4223-7017; 27592163; S-8384-2016; AAF-4610-2019; AAK-5370-2021; AAB-5802-2020
    Purpose: The study sought to evaluate the potential of diffusion-weighted magnetic resonance imaging to detect changes in liver diffusion in benign and malignant distal bile duct obstruction and to investigate the effect of the choice of b-values on apparent diffusion coefficient (ADC). Methods: Diffusion-weighted imaging was acquired with b-values of 200, 600, 800, and 1000 s/mm(2). ADC values were obtained in 4 segments of the liver. The mean ADC values of 16 patients with malignant distal bile duct obstruction, 14 patients with benign distal bile duct obstruction, and a control group of 16 healthy patients were compared. Results: Mean ADC values for 4 liver segments were lower in the malignant obstruction group than in the benign obstruction and control groups using b = 200 s/mm(2) (P < .05). Mean ADC values of the left lobe medial and lateral segments were lower in the malignant obstruction group than in the benign obstructive and control groups using b = 600 s/mm2 (P < .05). Mean ADC values of the right lobe posterior segment were lower in the malignant and benign obstruction groups than in the control group using b = 1000 s/mm(2) (P < .05). Using b = 800 s/mm(2), ADC values of all 4 liver segments in each group were not significantly different (P > .05). There were no correlations between the ADC values of liver segments and liver function tests. Conclusion: Measurement of ADC shows good potential for detecting changes in liver diffusion in patients with distal bile duct obstruction. Calculated ADC values were affected by the choice of b-values.
  • No Thumbnail Available
    Item
    Utility of Diffusion Weighted Magnetic Resonance Imaging with Multiple B Values in Evaluation of Pancreatic Malignant and Benign Lesions and Pancreatitis
    (2018) Karadeli, Elif; Erbay, Gurcan; Parlakgumus, Alper; Koc, Zafer; https://orcid.org/0000-0002-0352-8818; https://orcid.org/0000-0002-1706-8680; https://orcid.org/0000-0003-0987-1980; 29394967; AAK-5399-2021; AAK-5370-2021; S-8384-2016
    Objective: To determine the feasibility of diffusion-weighted imaging in evaluation of pancreatic lesions and in differentiation of benign from malignant lesions. Study Design: Descriptive study. Place and Duration of Study: Baskent University Adana Teaching and Research Center, Adana, Turkey, between September 2013 and May 2015. Methodology: Forty-three lesions [pancreas adenocarcinoma (n = 25)], pancreatitis (n = 10), benign lesion (n = 8)] were utilized with diffusion-weighted magnetic resonance imaging with multiple b-values. Different ADC maps of diffusion weighted images by using b-values were acquired. Results: The median ADC at all b values for malignant lesions was significantly different from that for benign lesions (p < 0.001). When ADCs at all b values were compared between benign lesions/normal parenchyma and malignant lesions/normal parenchyma, there was a significant statistical difference in all b values between benign and malignant lesions except at b 50 and b 200 (p<0.05). The lesion/normal parenchyma ADC ratio for b 600 value (AUC=0.804) was more effective than the lesion ADC for b 600 value (AUC=0.766) in differentiation of benign and malignant lesions. The specificity and sensitivity of the lesion/normal parenchyma ADC ratio were higher than those of ADC values of lesions. When the ADC was compared between benign lesions and pancreatitis, a significant difference was found at all b values (p<0.001). There was not a statistically significant difference between the ADC for pancreatitis and that for malignant lesions at any b value combinations (p>0.05). Conclusion: Diffusion-weighted magnetic resonance images can be helpful in differentiation of pancreatic carcinoma and benign lesions. Lesion ADC / normal parenchyma ADC ratios are more important than lesion ADC values in assessment of pancreatic lesions.