Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Pili Multigemini Is a Possible Risk Factor for Pilonidal Sinus Disease(2021) Ekici, Yahya; Moray, GokhanThe aim of this study is to analyze both previously proposed and new risk factors for the development of pilonidal sinus. This is a prospective case-control study consisting of 145 patients with pilonidal sinus disease (n = 45) and a control group (n = 100). All patients were admitted to the department of general surgery between January 2013 and May 2015. The patients' age, family history, medical history, sitting time in a day, sitting posture, body mass index (BMI), Garn hairiness score, and hair type were evaluated. There were significant differences between the groups in the following characteristics: age (P = 0.01); positive family history (P = 0.01); medical history (P = 0.01); sitting time in a day (P = 0.01); sitting posture (P = 0.01); BMI (P = 0.01); Garn score (P = 0.01); and hair type. Multivariate logistic regression analysis indicated that positive family history (P = 0.03); Garn score (P = 0.05); medical history (P = 0.01); and sitting posture (P = 0.02) were independent risk factors for the development of pilonidal sinus disease.Item The effect of static magnetic field on partial thickness burn wound healing(2019) Soy, Ebru H. Ayvazoglu; Aydin, Huseyin Onur; Terzi, Aysen; Ekici, Yahya; Moray, GokhanAim: During the past decades, there has been a substantial and growing evidence that static magnetic fields (SMF) and pulsed electromagnetic fields (EMF) can both produce satisfying therapeutic effects on various disorders. There have been researches about the efficacy of SMF in wound healing. However, there is no any investigation about the efficacy of SMF in burn wound healing. In this experimental study, we aimed to investigate the efficacy of SMF in partial thickness burn wound in rats. Material and Method: Forty male Sprague-Dawley male rats were used in the experiment. The modification of Sawada's bum model was applied. In Group1 magnets, in Group2 non-magnetic bars were placed vertically to the burn wound. In Group3 magnets, in Group4 non-magnetic bars were placed horizontally to the burn wound. The wound heating is evaluated by gross wound healing rate and histopathological examination. Results: In study groups, wound healing was faster, granulation with fibroblast migration was earlier, collagen production and neovascularisation were more than control groups. We found no relationship between wound healing and vector direction. Discussion: According to these results static magnetic field can be used in clinic to promote the healing in patients with burns. Especially, in cases that have no chance for grafting, to decrease complications and increase the survival, the static magnetic field can be an alternative.Item Effect of Topical Platelet-Rich Plasma on Burn Healing After Partial-Thickness Burn Injury(2016) Ozcelik, Umit; Ekici, Yahya; Bircan, Huseyin Yuce; Aydogan, Cem; Turkoglu, Suna; Ozen, Ozlem; Moray, Gokhan; Haberal, Mehmet; 27262706Background: To investigate the effects of platelet-rich plasma on tissue maturation and burn healing in an experimental partial-thickness burn injury model. Material/Methods: Thirty Wistar albino rats were divided into 3 groups of 10 rats each. Group 1 (platelet-rich plasma group) was exposed to burn injury and topical platelet-rich plasma was applied. Group 2 (control group) was exposed to burn injury only. Group 3 (blood donor group) was used as blood donors for platelet-rich plasma. The rats were killed on the seventh day after burn injury. Tissue hydroxyproline levels were measured and histopathologic changes were examined. Results: Hydroxyproline levels were significantly higher in the platelet-rich plasma group than in the control group (P=.03). Histopathologically, there was significantly less inflammatory cell infiltration (P=.005) and there were no statistically significant differences between groups in fibroblast development, collagen production, vessel proliferations, or epithelization. Conclusions: Platelet-rich plasma seems to partially improve burn healing in this experimental burn injury model. As an initial conclusion, it appears that platelet-rich plasma can be used in humans, although further studies should be performed with this type of treatment.Item Arterial complication of irreversible electroporation procedure for locally advanced pancreatic cancer(2016) Ekici, Yahya; Tezcaner, Tugan; Aydin, Huseyin Onur; Boyvat, Fatih; Moray, Gokhan; 0000-0003-3795-5794; 0000-0003-2498-7287; 0000-0002-3641-8674; 27795815; S-8185-2018; AAE-1041-2021; M-1422-2019; AAD-9865-2021; F-4230-2011Irreversible electroporation (IRE) is a non-thermal ablation technique used especially in locally advanced pancreatic carcinomas that are considered surgically unresectable. We present the first case of acute superior mesenteric artery (SMA) occlusion secondary to pancreatic IRE procedure that has not been reported before in the literature. A 66-year-old man underwent neoadjuvant chemoradiotherapy for locally advanced pancreatic ductal adenocarcinoma. IRE procedure was applied to the patient during laparotomy under general anesthesia. After finishing the procedure, an acute intestinal ischemia was detected. A conventional vascular angiography was performed and a metallic stent was successfully placed to the SMA and blood flow was maintained. It is important to be careful in such cases of tumor involvement of SMA when evaluating for IRE procedure of pancreatic tumor.Item Laparoscopic spleen-preserving distal pancreatectomy for a primary hydatid cyst mimicking a mucinous cystic neoplasia(2017) Tezcaner, Tugan; Ekici, Yahya; Aydin, Onur Huseyin; Barit, Gonca; Moray, Gokhan; 0000-0003-2498-7287; 0000-0002-3641-8674; 0000-0003-3795-5794; 28281482; AAE-1041-2021; AAD-9865-2021; M-1422-2019; S-8185-2018Pancreatic hydatid cysts are fairly rare. The disease can be encountered concurrently with systemic involvement or as an isolated pancreatic involvement. We report the first case of spleen-preserving laparoscopic distal pancreatectomy for a pancreatic hydatid cyst. There was no complication or recurrence. A 55-year-old woman was admitted to our centre with epigastric and back pain. Upper abdominal magnetic resonance imaging revealed a solitary cystic lesion with septations at the pancreatic tail level measuring 24 mm x 18 mm, which was initially thought to be a pancreatic mucinous cystic neoplasia. She underwent laparoscopic spleen-preserving distal pancreatectomy and cholecystectomy. Her post-operative course was uneventful and histopathological examination revealed a hydatid cyst in the pancreatic tail.Item Long-term and Perioperative Outcomes of Laparoscopic and Open Surgery for Rectal Cancer(2018) Aydin, Huseyin Onur; Ekici, Yahya; Karakayali, Feza Yarbug; Tezcaner, Tugan; Ozgun, Gonca; Yildirim, Sedat; Moray, GokhanObjectives: The necessity of comparing oncologic results with the use of minimally invasive surgery in rectal cancer has arisen. The aim of the present study was to evaluate the treatment approach in rectal cancer and to compare the outcomes of laparoscopic and open surgery. Methods: Patients who underwent surgery for rectal carcinoma between January 2006 and January 2016 in our institution were evaluated. The results were compared between the two groups according to open or laparoscopic surgery. Clinical characteristics, preoperative and postoperative results, pathological examination results, and disease-free survival rates were compared after the surgical procedure. Results: A total of 121 patients were included in the study. Of the patients, 50 underwent open, and 71 underwent laparoscopic surgery. The median follow-up times were 56.75 months in the open surgery group and 55.2 months in the laparoscopic surgery group. Pathological examination revealed similar numbers of lymph nodes in both groups (p>0.05). The duration of hospital stay was statistically significantly lower in the open surgery group than in the laparoscopic group (p<0.05). The rates of disease-free survival were 74% in the open surgery group and 82.5% in the laparoscopic group, and no statistically significant difference was found (p>0.05). Conclusion: There was no significant difference in complication and recurrence between laparoscopic and open surgery for rectal cancer in our study. The duration of hospital stay of patients was statistically significantly lower in the laparoscopic group than in the open surgery group. Laparoscopic or open surgical options could be preferred according to the clinical suitability of the patient, experience of the surgeon, and resources of the center in rectal cancer treatment.Item Hemodiyaliz için enfiye çukuru (snuff-box) arteriyovenöz fistüller(Damar Cerrahisi Dergisİ ,17 (2) ,73-80, 2008) Ekici, Yahya; Karakayalı, Feza Yarbuğ; Yağmurdur, Mahmut Can; Kırnap, Mahir; Moray, Gökhan; Haberal, MehmetBu çalışmada amacımız kliniğimizde gerçekleştirdiğimiz enfiye çukuru arteriyovenöz fistüllerin sonuçlarını analiz ederek bu yöntemi tartışmaktır. Gereç ve Yöntemler: 1999-2007 yılları arasında kliniğimizde düzenli takipleri olan 272 enfiye çukuru arteriyovenöz fıstül geriye dönük olarak değerlendirildi. Gerekli bilgiler hasta dosyalarından ve diyaliz notlarından elde edilmiştir. Tüm olgular yaş, cinsiyet, son dönem böbrek yetmezliği etyolojisi, fistül olgunlaşma ve fistül açıklık oranları açısından değerlendirilmiştir. Bulgular: Hastaların 115'i (%44) kadın, 143 u (%56) erkek ve ortalama yaşları 40.5±8.5 idi. Ortanca takip süresi 50 ay (3-65 ay)'dır. Etyolojide en sık görülen neden %32 diabetes mellitustur. Altı hafta sonundaki olgunlaşma oranı %85 olarak tespit edildi. Bir yıllık açıklık oranları %82 ve 4 yıllık açıklık oranı %53'dir. Fistül açıklık oranları diyabetik olan ve olmayanlarda, erkekler ve kadınlarda, sağ kol ve sol kol AVF'lerde karşılaştırıldığında istatistiksel olarak anlamlı farklılık olmadığı görülmüştür. Sonuç: İyi bir fizik muayene ile enfiye çukuru fistülün uygunluğu değerlendirilebilir. Enfiye çukuru fistüllerin iyi olgunlaşma ve uzun dönem açıklık oranları vardır. İlk fistül açılacak uygun hastalarda iyi bir seçimdir. In this study, we aimed to discuss this method by analyzing snuff-box arteriovenous fistula outcomes in our experience. Material and Methods: We analyzed the outcomes of 272 snuffbox arteriovenous fistulas created between 1999-2007. Data was determined patients charts and dialysis records. Patients' demographics, end stage renal disease etiology, fistula maturation and patency rates, complications were evaluated retrospectively. Results: Of the 272 patients, 115 (46%) were women and 143 (54%) were men. The mean age of patients was 40.5+8.5. median follow up period of fistulas was 50 months (range 3-65 months). The most frequent etiologic disease of end stage renal disease was Diabetes mellitus (32%). The maturation rate of snuffbox arteriovenous fistula was 85%. One year and 4 year patency rates were 82% and 53 % respectively. Diabetes, sex and side of the extremity did not significantly affect fistula survival. Conclusion: Feasibility of snuff-box arteriovenous fistula was evaluated with the physical examination of this area. Snuffbox arteriovenous fistulas have good maturation and long-term patency rates. This type of fistulas may be the first choice for suitable patients requiring primary access.Item Sekonder hiperparatiroidizm tedavisinde subtotal paratiroidektominin etkinliği: Bir merkezin sonuçları(Ulusal Cerrahi Dergisi ,23 (2) ,41-45, 2007) Ekici, Yahya; Pehlivan, Sema; Karakayalı, Feza Yarbuğ; Sevmiş, Şinasi; Yağmurdur, Mahmut Can; Moray, Gökhan; Haberal, MehmetBu çalışmada amaç sekonder hiperparatiroidi nedeniyle hastanemizde yapılan subtotal paratiroidektomi sonuçlarını değerlendirmektir. Yöntem: Merkezimizde sekonder hiperparatiroidi nedeniyle ameliyat edilen 36 hastanın dosyaları retrospektif olarak incelendi. Ameliyat öncesi ve sonrası dönemdeki klinik bulgular, serum kalsiyum, fosfor, parathormon ve alkalen fosfataz değerleri ile cerrahi komplikasyonlar değerlendirildi. Bulgular: Ortalama takip süresi 28.4±20 aydı ve geride kalan dokuya yönelik cerrahi girişim gerektirecek rekürrens görülmedi. Ameliyattan önce yüksek parathormon düzeyi (ortalama 1536.3±674.6 pg/ml) saptanan tüm hastalarda ameliyat sonrası takiplerde parathormon düzeyi ortalama 128±91 pg/ml bulundu. Ameliyat öncesi dönemde serum kalsiyum düzeyleri ortalama 10.4±0.8 mg/100 ml, fosfor düzeyi ortalama 6.2±1.7 mg/100 ml'di. Ameliyattan sonraki takipte ortalama serum kalsiyumu 8.1±1.2 mg/100 ml (7.7-10 mg/100 ml) ve serum fosforu 4.7±1.4 mg/100 ml (4.1-8.6 mg/100 ml) olarak saptandı. Yüksek alkalen fosfataz düzeyleri ameliyattan sonra tüm hastalarda ortalama 172±49 U/L olarak saptandı. Ameliyat öncesi görülen kas güçsüzlüğü, şiddetli kaşıntı gibi bulgular ameliyat sonrası dönemde geriledi. Sadece 2 hastada semptomatik hipokalsemi görüldü ve tedavileri yapıldı. Sonuç: Paratiroid cerrahisi kronik böbrek yetmezlikli hastalarda gelişen sekonder hiperparatiroidizmde halen önemini koruyan ve gerekli olan bir tedavi seçeneğidir. Deneyimimize göre subtotal paratiroidektomi sekonder hiperparatirioidi tedavisinde başarılı ve etkili bir yöntem olarak görülmektedir. The aim of this study was to evaluate the efficacy of subtotal parathyroidectomy performed in end stage renal disease patients for secondary hyperparathyroidism in our center.Materials and Methods: The study involved 36 consecutive patients. Preoperative and postoperative clinical signs and symptoms, parathormon, calcium, phosphorus, alkaline phosphatase and surgical complications were evaluated. Results: 36 patients remain cured at a mean follow up time 28.4±20 months. None of the patients required resection of parathyroid remnant. Preoperative high parathormon levels (mean 1536.3±674.6 pg/ml) decreased (mean 128±91 pg/ml) during follow-up period. Preoperative mean serum calcium level was 10.4±0.8 mg/100 ml and the mean serum phosphorus level was 6.2±1.7 mg/100 ml. During follow up period, the mean serum calcium level was 8.1±1.2 mg/100 ml (7.7 to 10 mg/100 ml) and the mean serum phosphorus level was 4.7±1.4 mg/100 ml (4.1 to 6.6 mg/100 ml). Serum alkaline phosphatase returned to normal after the operation (mean 172±49 U/L). Preoperative symptoms such as pruritis and fatigue improved after operation. Two patients treated successfully for symptomatic hypocalcemia in the early postoperative period. Conclusion: Parathyroidectomy still remains the important therapeutic option for secondary hyperparathyroidism associated with end stage renal disease. Our results indicate that subtotal parathyroidectomy is the effective treatment for secondary hyperparathyroidism.