Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item The African Variant of BKV in A Turkish Renal Transplant Patient(2014) Colakoglu, Sule; Dursun, Hasan; Cengiz, Nurcan; Bulat, Meryem Cosar; Noyan, Aytul; https://orcid.org/0000-0002-8817-494X; 24726687; AAB-7105-2020; GPX-7059-2022; AAD-5713-2021In renal transplant recipients, BK polyomavirus (BKV) is linked to nephropathy. BK virus genotypes have a strong geographic component. This paper presents the African variant of BKV in a Turkish renal transplant patient, which is a rare cause of infection in the Northern Hemisphere and, to our knowledge, the first case from Turkey. (C) 2014 Elsevier Inc. All rights reserved.Item Results of Turkish Multicentric National Cystinosis Registry(2015) Topaloglu, Rezan; Gulhan, Bora; Ozaltin, Fatih; Bodur, Ilknur; Besbas, Nesrin; Dursun, Hasan; Yilmaz, Alev; Gurgoze, Metin Kaya; Gokce, Ibrahim; Akinci, Nurver; Erdogan, Ozlem; Dursun, Ismail; Canpolat, Nur; Donmez, Osman; Cayci, Fatma Semsa; Serdaroglu, Erkin; Comak, Elif; Nalcacioglu, Hulya; Gok, Faysal; Yuksel, Selcuk; Soylu, Alper; Bahat, Elif; Hacihamdioglu, Duygu Ovunc; Candan, Cengiz; Bastug, Funda; AAW-8783-2020Item Pediatric Renal Transplantation: A Single Center Experience(2015) Dursun, Hasan; Cengiz, Nurcan; Noyan, Aytul; Caliskan, Kenal; Basturk, Bilkay; Yildirim, Sedat; Moray, Gokhan; Baskin, Esra; Haberal, Mehmet; 0000-0002-5735-4315; 0000-0002-8817-494X; 0000-0003-2498-7287; 0000-0002-3462-7632; 0000-0003-4361-8508; 0000-0002-8784-1974; AAF-4610-2019; AAB-7105-2020; AAE-1041-2021; AAJ-8097-2021; AAD-5713-2021; B-5785-2018; AAD-6918-2021Item Prevalence of Hypertension in Children and Adolescents with Unclassified Headache(2015) Dursun, Hasan; Saygi, Semra; Cengiz, Nurcan; Savas, Tulin; Erol, Ilknur; Noyan, Aytul; 0000-0002-8817-494X; 0000-0002-3530-0463; 0000-0002-8522-5078; AAB-7105-2020; AAK-4825-2021; AAD-5713-2021; AAB-1203-2021Item Potentially Reversible Encephalopathy in Children with Chronic Renal Failure(2015) Dursun, Hasan; Cengiz, Nurcan; Saygi, Semra; Alkan, Ozlem; Savas, Tulin; Noyan, Aytul; 0000-0002-8817-494X; 0000-0001-7526-3460; 0000-0002-8522-5078; AAB-7105-2020; AAM-4169-2021; AAB-1203-2021; AAD-5713-2021Item Urinary Ngal, Kim-1 and L-fabp Levels in Patients with Vesicoureteral Reflux(2014) Parmaksiz, Gonul; Noyan, Aytul; Dursun, Hasan; Ince, Emine; Anarat, Ruksan; Cengiz, Nurcan; https://orcid.org/0000-0003-2373-1837; https://orcid.org/0000-0002-8817-494X; AAM-2935-2021; AAD-5713-2021; AAB-7105-2020Item Urinary Ngal, Kim-1 and L-fabp Levels in Antenatal Hydronephrosis(2014) Dursun, Hasan; Noyan, Aytul; Parmaksiz, Gonul; Ezer, Semire Serin; Anarat, Ruksan; Cengiz, Nurcan; https://orcid.org/0000-0002-8817-494X; https://orcid.org/0000-0003-2373-1837; AAW-8783-2020; AAD-5713-2021; AAM-2935-2021; AAJ-9529-2021Item Urinary NGAL, KIM-1 and L-FABP Concentrations in Antenatal Hydronephrosis(2015) Noyan, Aytul; Parmaksiz, Gonul; Dursun, Hasan; Ezer, Semire Serin; Anarat, Ruksan; Cengiz, Nurcan; 0000-0002-8817-494X; 0000-0003-2373-1837; 0000-0002-9597-3264; 26096437; AAJ-9529-2021; AAB-7105-2020; AAD-5713-2021; AAW-8783-2020; GPX-7059-2022; AAM-2935-2021The clinical tests currently in use for obstructive nephropathy (such as renal ultrasonography, differential radionuclide renal scans and urinary creatinine concentration data) are not efficient predictors of the subsequent clinical course. Novel and simple biomarkers are required which, if proven, could be clinically beneficial in determining if a patient is eligible for surgery or reno-protective therapy. More recently, the interest of clinicians has focused on the potential of urinary neutrophil gelatinase-associated lipocalin (uNGAL), urinary kidney injury molecule-1 (uKIM-1) and urinary liver-type fatty acid-binding proteins (uL-FABP) as biomarkers for renal function in children with hydronephrosis (HN). Objective The purpose of this study was to investigate possible clinical applications of uNGAL, uKIM-1 and uL-FABP as beneficial non-invasive biomarkers to determine whether or not surgical intervention is required in children with HN. Study design Renal ultrasonography and radionuclide renal scans were used as diagnostic tools to detect HN. Patients were divided into two groups based on the anteroposterior diameter of their renal pelvis and the presence of dysfunction. Group 1 included 26 children with severe HN (with dysfunction), and group 2 consisted of 36 children with mild HN (without dysfunction). Urine samples were collected from 62 children with HN and 20 healthy children. Results Hydronephrosis was more common in males than in females, with a male to female ratio of 9: 1 in the study sample. The incidence of left kidney involvement (32 patients) was slightly higher than right kidney involvement (28 patients). Compared with controls and group 2, the ratio of uNGAL to creatinine was significantly higher in group 1 (p < 0.05). The biomarker uNGAL/Cr exhibited fairly good diagnostic accuracy, with an area under the curve of 0.68 [95% confidence interval 0.6-0.7] and an optimal cut-off value of 0.16 ng/mg Cr (sensitivity 58%, specificity 75%) (p < 0.05). There was a positive correlation between the uNGAL/Cr ratio and the uKIM-1/Cr ratio (r = 0.582, p < 0.05) and uL-FABP/Cr ratio (r = 0675, p < 0.05) in group 1. Discussion The results clearly demonstrated that children with hydronephrosis and dysfunction had significantly increased uNGAL, and uNGAL/Cr concentrations. However, uKIM-1, uKIM-1/Cr, uL-FABP and uL-FABP/Cr concentrations were not significantly different when compared with controls. These results support the use of uNGAL concentrations as an early marker for renal dysfunction in HN. Conclusions The study clearly demonstrated that pediatric patients with hydronephrosis and dysfunction had significantly higher uNGAL to creatinine concentrations as compared with controls.Item Role of New Biomarkers for Predicting Renal Scarring in Vesicoureteral Reflux: NGAL, KIM-1, And L-FABP(2016) Parmaksiz, Gonul; Noyan, Aytul; Dursun, Hasan; Ince, Emine; Anarat, Ruksan; Cengiz, Nurcan; https://orcid.org/0000-0003-2373-1837; 26324091; AAM-2935-2021; AAD-5713-2021; AAW-8783-2020Reflux nephropathy is the most serious complication of vesicoureteral reflux (VUR). The aim of this study was to assess the role of urinary levels of neutrophil-gelatinase-associated lipocalin (NGAL),kidney injury molecule-1 (KIM-1), and liver-type fatty-acid-binding protein (L-FABP) in the early diagnosis of reflux nephropathy in patients with VUR. This study assessed 123 patients with primary VUR and 30 healthy children as a control group. The children were divided into five groups: Group A, patients with VUR and renal parenchymal scarring (RPS); Group B, patients with VUR and without RPS; Group C, patients with RPS and resolved VUR; Group D, patients with resolved VUR and without RPS; Group E, healthy reference group. Median urinary NGAL (uNGAL)/Creatinine (Cr) was significantly higher in patients with than those without RPS and the control group (p = 0.0001). Median uKIM-1/Cr was similar in all groups (p = 0.417). Median uL-FABP/Cr was significantly higher in patients with RPS than in the reference group (p < 0.05). Urinary NGAL levels may be used as a noninvasive diagnostic marker for predicting renal scarring in reflux nephropathy.Item Cytomegalovirus Infection in Pediatric Renal Transplantation and the Impact of Chemoprophylaxis With (Val-)Ganciclovir(2016) Hoecker, Britta; Zencke, Sebastian; Krupka, Kai; Fichtner, Alexander; Pape, Lars; Dello Strologo, Luca; Guzzo, Isabella; Topaloglu, Rezan; Kranz, Birgitta; Koenig, Jens; Bald, Martin; Webb, Nicholas J. A.; Noyan, Aytul; Dursun, Hasan; Marks, Stephen; Yalcinkaya, Fatos; Thiel, Florian; Billing, Heiko; Pohl, Martin; Fehrenbach, Henry; Bruckner, Thomas; Toeshoff, Burkhard; https://orcid.org/0000-0002-8817-494X; 26736017; AAD-5713-2021; AAB-7105-2020Background. Cytomegalovirus (CMV) replication and disease, with its associated morbidity and poor transplant outcome, represents a serious threat to transplant recipients. The pediatric kidney transplant population is at a particularly increased risk of CMV infection. Methods. We therefore analyzed CMV epidemiology in a large cohort of pediatric renal transplant recipients (n = 242) and assessed the impact of antiviral chemoprophylaxis with valganciclovir (VGCV) or ganciclovir (GCV) on CMV replication and morbidity. Results. While antiviral chemoprophylaxis with VGCV or GCV in patients with a high (D+/R-) or intermediate (D+/R+) CMV risk (n = 82) compared to preemptive therapy (n = 47) had no significant effect on the incidence of CMV syndrome or tissue-invasive disease, chemoprophylaxis was associated with a better preservation of transplant function at 3 years posttransplant (loss of estimated glomerular filtration rate in the chemoprophylaxis cohort, 16.0 +/- 3.4 vs. 30.1 +/- 4.7 mL/min per 1.73 m(2) in the preemptive therapy cohort, P < 0.05). CMV replication was associated with amore pronounced decline of graft function (difference in estimated glomerular filtration rate of 9.6 mL/min per 1.73 m(2) at 3 years) compared to patients without CMV replication. However, patients undergoing VGCV or GCV chemoprophylaxis had more leukocytopenia. Conclusion. Antiviral chemoprophylaxis with VGCV or GCV in recipients with a high or moderate CMV risk is associated with a better preservation of transplant function. Hence, the prevention of CMV replication in this patient population has the potential to improve transplant outcome.