Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Routinely Evaluated Clinical Assays and Laboratory Tests [Real Test] And Fibrosis Stages of Chronic Hepatitis B and C(2014) Bugdaci, Mehmet Sait; Korkmaz, Huseyin; Demir, Ali; Biyik, Murat; Temel, Tuncer; Gokturk, Huseyin Savas; Ozakyol, Aysegul; Hatemi, Ibrahim; Baysal, Birol; Karaca, Cetin; Senturk, Hakan; 25417616Background/Aims: To provide a new mathematical formula to predict liver fibrosis in patients with chronic viral hepatitis. Materials and Methods: Patients with chronic hepatitis B and C who underwent liver biopsy at different centers were included in this study. Chronic hepatitis B was defined as immunopositivity for the hepatitis B surface antigen for at least 6 months, and chronic hepatitis C was defined as positivity for HCV RNA for at least 3 months. The histological features were evaluated by the histological activity index and fibrosis. Results: In total, 1299 patients were included in the study. The distribution and the mean of the parameters of the patients were as follows: 1009 patients with chronic hepatitis B with a mean age of 45 +/- 13/years [emale/male (F/M)=47.5/52.5%] and 290 patients with hepatitis C with a mean age of 52 +/- 10.3/years [F/M=61/39%]. When the cut-off value of the REAL TEST formula"[(age x pT x AST)/(PLT/1000)]/100" in patients with hepatitis B was determined to be >= 1.37, it was found that it could predict fibrosis with 79% specificity, 78% sensitivity, 85% negative predictive value (NPV), and 70% positive predictive value (PPV) (area under the curve (AUC)=0.852, 95% CI: 0.82-0.87). When the cut-off value of the REAL TEST formula in patients with hepatitis C was determined to be >= 1.99, it was found that it could predict significant fibrosis with 87% specificity, 90% sensitivity, 94.4% NPV, and 79.4% PPV (AUC: 0.95, 95% CI: 0.93-0.98) Conclusion: The REAL TEST formula results correlated with the pathological findings and may be a useful method for the evaluation of patients with chronic hepatitis B and C.Item Evaluation of The Effect of Lipid Emulsıon Therapy on The Rat Model in Organophosphate Intoxication and Tissue Pathologies(2014) Celikel, Elif; Arslan, Engin Deniz; Yilmaz, Fevzi; Turhan, Turan; Unal, Muge Tecder; Turhan, Turan; Turhan, Nesrin; Kavalci, Cemil; Karakilic, M. Evvah; Altunkaynak, Hande Ozge; Unal, Muge Tecder; Demir, Ali; AAH-5151-2020Introduction and objective: Organophosphates are frequently used for agricultural spraying in an uncontrolled manner in our country. Humans are usually inadvertently exposed to these chemicals via respiratory, transdermal, or tranconjunctival routes whereas they may also be used for suicidal purposes: Having a high morbidity and mortality, this intoxication causes a high emergency department admission rate (1). Previous studies on lipid therapy in cardiac arrest associated with intoxication of lipophilic agents such as antidepressants, anticonvulsants, antihypertensives, and local anesthetics have reported a 55% increase in survival with these therapies (2). We also studied lipid emulsion therapy (LET) in poisoning with organophosphates that are lipophilic. Materials and method: This study used 30 male Wistar-albino rats of 12 months of age weighting 288 to 428 gr. The animals were randomly grouped into 5 groups: Group 1 Was the control group; Group 2 organophosphate+serum physiologic (SF) group; Group 3 organophosphate+LET group; Group 4 arganophosphate + Atropin(A)+ Pralidoxime (PAM) group; and Group 5 organophosphate+LET+A+PAM group. After an 8-hour clinical observation period the rats were sacrificed and Wad pseudocholitiesterase, cholesterol; and triglyceride levels were studied. Renal, hepatic, splenic, and cerebral tissues were sampled to be examined under light microscope. Results : There were significant differences between the groups with respect to cholesterol, triglyceride, but not pseudocholine-sterase level Dizziness was the first observed clinical symptom, followed by hindleg paralysis, foreleg paralysis, and general paralysis. After general paralysis salivation was usually observed together with gasping breathing. Rats with the above clinical course were sacrificed. The clinical picture progressed rapidly after foreleg paralysis. The toxic clinical course was observed in 100% of rats in Group 2 (organophosphate + SF) and Group 3 (Organophosphate +LET) and its mortality rate was high. No significant difference was observed between both groups with respect to time to symptom onset. This may be interpreted as that LET treatment alone was not effective. Conclusion: In the present study we did not observe any beneficial effect of LE treatment alone on mortality of organophosphate intoxication. According to our results, however, it may be beneficial when used in conjunction to Classical therapy. Considering its relatively low side effect profile and pros and cons, we believe that it can be used as a supportive therapy in organophosphate poisoning.Item Comparison of Low and High Grade Glioma Maps(2015) Cotur, Yasin; Ozkan, Mehmed; Demir, Ali; Turnaoglu, Hale; Agildere, Ahmet M.; Alkan, Ozlem; Ulug, Aziz M.; 0000-0002-0781-0036; 0000-0003-4223-7017; AAK-8242-2021; AAB-5802-2020It is crucial to detect the locations of brain tumors for the diagnosis. The aim of this study was the generation and comparison of the high and low-grade probabilistic brain tumor maps to present the tumor observance frequencies in the brain tissue. T1-weighted, pre-operated data from 162 brain tumor patients are examined during the study. Although most of high-grade tumors are located around the superior and right lateral regions of sub-ventricular zone, low-grade gliomas are mostly observed in the posterior part of the sub-ventricular zone. Moreover, since all types of tumors are gathered close to the sub-ventricular zone, our results support the theory proposing that there is a relation between gliomas and sub-ventricular zone, which is the origin of glial cells.