Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
Browse
7 results
Search Results
Item Luteal Phase Support After Mild Ovulation Induction with Intrauterine Insemination: An On-Going Debate(2016) Aytac, Pinar Caglar; Bulgan Kilicdag, Esra; Haydardedeoglu, Bulent; Simsek, Erhan; Cok, Tayfun; Coban, Gonca; 0000-0002-3285-5519; 0000-0002-0942-9108; 0000-0003-1244-7419; 26850073; AAI-9974-2021; AAC-9940-2020; AAK-8872-2021; AAH-5686-2020Objective: To evaluate the effect of luteal phase support (LPS) using progesterone vaginal gel on pregnancy rate (PR) and live birth rate (LBR) during cycles in which controlled ovarian stimulation (COH) was performed using gonadotropins with intrauterine insemination (IUI) cycles in patients with unexplained infertility and polycystic ovarian syndrome.Materials and methods: From 2010 to 2015, all IUI cycles in which COH was performed using gonadotropins were evaluated retrospectively. LPS was not used until July 2013, after which vaginal progesterone gel was applied in the luteal phase of IUI cycles. Both groups of patients were evaluated in terms of the effect of LPS on PR and LBR.Results: In total, 1578 IUI cycles were evaluated, of which 481 were LPS (+) and 1097 LPS (-). PR and LBR per cycle were 10.6% and 7.4%, respectively, in the LPS (+) group, and 11.6% and 7.7%, respectively, in the LPS (-) group (p=0.31 and p=0.25). PR and LBR per patient were 17% and 12%, respectively, in the LPS (+) group, and 17.4% and 12.3%, respectively, in the LPS (-) group (p=0.48 and p=0.82).Conclusions: We found no difference in PR and LBR per cycle and per patient according to the use of LPS in IUI cycles in which COH was performed using gonadotropins. Thus, routine use of LPS in gonadotropin-stimulated cycles requires further research involving larger numbers of patients.Item Can Predict Intraoperative Vaginal Irrigation Cytology Vaginal Spillage on Endometrial Cancer(2016) Coban, Gonca; Alemdaroglu, Songul; Yetkinel, Selcuk; Bolat, Filiz Aka; Celik, Husnu; 0000-0003-4335-6659; 0000-0002-3285-5519; 0000-0002-2165-9168; 0000-0003-2031-7374; AAI-8400-2021; AAI-9974-2021; AAL-1530-2021; HJZ-1654-2023; AAL-1923-2021Item A Rare Lesion of The Clitoris: Atypical Cellular Blue Naevus: Case Report(2017) Ozdemir, Elif Didem; Yalcinkaya, Cem; Coban, Gonca; Canpolat, Tuba; Heper, Aylin Okcu; Celik, Husnu; https://orcid.org/0000-0002-3285-5519; 27924655; AAI-9974-2021; AAK-8107-2021; AAL-1923-2021Item Malignancy in Cases with Suspected Mature Cystic Teratoma in The Preoperative and Intraoperative Evaluations(2018) Coban, Gonca; Yalcinkaya, Cem; Kalayci, Hakan; Bolat, Filiz Aka; Celik, Husnu; https://orcid.org/0000-0002-3285-5519; https://orcid.org/0000-0003-2031-7374; AAI-9974-2021; HJZ-1654-2023; AAL-1923-2021Objective: To report cases who were suspected to have mature cystic teratoma in the preoperative and intraoperative periods, but were found to have malignancy together with mature cystic teratoma in the final histopathological examination. Materials and Methods: The medical records of 148 cases were retrieved. The records were used to review the sociodemographic properties, histopathology, intraoperative tumor size, the surgical procedure, adjuvant therapy, and follow-up of the patients who were suspected to have mature cystic teratoma in the preoperative and intraoperative periods, but were found to have malignancy together with mature cystic teratoma in the frozen or final histopathological examination. Results: Of the patients, 8.2% were found to have malignancy arising in mature cystic teratoma. The median age of the patients was 32- (min: 15, max: 66) years-old and the tumor size was 12.1 (min: 4, max: 25) cm. Six patients were established to have an immature teratoma, three had a carcinoid tumor, one had a primitive neuro-extrodermal tumor (PNET), one had serous borderline tumor, and one had a borderline mucinous tumor. Conclusion: Although a mature cystic teratoma is benign, since it may involve different degrees of malignancy, intraoperative attitudes and procedures should follow the rules that apply to the management of a complicated adnexal mass and the possibility of a malignant transformation should be in kept in mind when informing the patient in the preoperative period.Item Is The Presence of Endometriosis Associated with A Survival Benefit in Pure Ovarian Clear Cell Carcinoma?(2018) Sahin, Hanifi; Sari, Mustafa Erkan; Cuylan, Zeliha Firat; Haberal, Asuman Nihan; Sirvan, Levent; Coban, Gonca; Yalcin, Ibrahim; Gungor, Tayfun; Celik, Husnu; Meydanli, Mehmet Mutlu; Ayhan, Ali; https://orcid.org/0000-0001-9852-9911; https://orcid.org/0000-0002-3285-5519; AAJ-5802-2021; 29383437; AAK-4587-2021; AAI-9974-2021; AAL-1923-2021The purpose of this study was to compare the prognoses of women with pure ovarian clear cell carcinoma (OCCC) arising from endometriosis to those of women with pure OCCC not arising from endometriosis treated in the same manner. A dual-institutional, retrospective database review was performed to identify patients with pure OCCC who were treated with maximal or optimal cytoreductive surgery (CRS) followed by paclitaxel/carboplatin chemotherapy between January 2006 and December 2016. Patients were divided into two groups according to the detection of cancer arising in endometriosis or not, on the basis of pathological findings. Demographic, clinicopathological, and survival data were collected, and prognosis was compared between the two groups. Ninety-three women who met the inclusion criteria were included. Of these patients, 48 (51.6%) were diagnosed with OCCC arising in endometriosis, while 45 (48.4%) had no concomitant endometriosis. OCCC arising in endometriosis was found more frequently in younger women and had a higher incidence of early stage disease when compared to OCCC patients without endometriosis. The 5-year overall survival (OS) rate of the patients with OCCC arising in endometriosis was found to be significantly longer than that of women who had OCCC without endometriosis (74.1 vs. 46.4%; p = 0.003). Although univariate analysis revealed the absence of endometriosis (p = 0.003) as a prognostic factor for decreased OS, the extent of CRS was identified as an independent prognostic factor for both recurrence-free survival (hazard ratio (HR) 8.7, 95% confidence interval (CI) 3.15-24.38; p < 0.001) and OS (HR 11.7, 95% CI 3.68-33.71; p < 0.001) on multivariate analysis. Our results suggest that endometriosis per se does not seem to affect the prognosis of pure OCCC.Item The Nomogram of Prenasal Thickness and Nasal Bone Ratio and Its Relationship with Nuchal Fold in Second-Trimester Fetal Ultrasound(2018) Ozdemir, Halis; Kalayci, Hakan; Yetkinel, Selcuk; Cok, Tayfun; Coban, Gonca; Tarim, Ebru; 0000-0002-9194-8504; 0000-0002-2165-9168; 0000-0003-1244-7419; 0000-0002-3285-5519; 29570920; I-5479-2017; AAL-1530-2021; AAI-9974-2021AimWe aimed to define the normal values of second-trimester fetal prenasal thickness and nasal bone length ratio (PNT/NBL) in a low-risk Turkish population and investigate the relationship between the increased PNT and nuchal fold (NF). MethodWe retrospectively reviewed the data of 650 cases considered to be euploid fetuses who presented to our clinic between December 2013 and September 2014 for a second-line ultrasound between 17 and 24 weeks. Their PNT, NBL, NF and biometric (BPD, HC, AC, FL and HL) measurements were recorded. ResultsA total of 650 cases considered to be euploid fetuses were included in this study. There was a linear increase in PNT with the gestational weeks (mean value 3.01 at weeks 17-18 and 3.76 at weeks 23-24). The PNT/NB ratio showed a slight decrease in advancing gestational weeks (mean value 0.57 at weeks 17-18 and 0.50 at weeks 23-24). The 95th percentile value of the PNT/NB ratio, independent of the gestational week, was 0.76. The values of both PNT and NF increased with advancing gestational weeks, but there was no statistically linear increase between PNT and NF (R-2: 0.115). ConclusionIn this study, we provided a nomogram of the PNT/NB ratio. Both NF thickness and PNT should be dealt with as two separate markers. Although the formation mechanisms are thought to be the same in both of them, a strong linear relationship does not exist between them.Item Risk Factors for Lymph Node Metastasis among Lymphovascular Space Invasion-Positive Women with Endometrioid Endometrial Cancer Clinically Confined to the Uterus(2018) Sari, Mustafa Erkan; Meydanli, Mehmet Mutlu; Yalcin, Ibrahim; Sahin, Hanifi; Coban, Gonca; Celik, Husnu; Kuscu, Esra; Gungor, Tayfun; Ayhan, Ali; 0000-0002-3285-5519; 0000-0002-0992-6980; 30419557; AAD-8494-2019; AAI-9974-2021; AAL-1923-2021; AAI-8792-2021; AAJ-5802-2021Introduction: We aimed to assess risk factors for lymph node (LN) metastasis among lymphovascular space invasion(LVSI)-positive women with pure endometrioid endometrial cancer (EC) clinically confined to the uterus. Methods: Medical records of women who underwent primary surgery for EC between 2007 and 2016 at either of 2 gynecological oncology centers were retrospectively reviewed. Patient data were analyzed with respect to LN involvement, and predictive factors for LN metastasis were investigated. Results: 280 patients with surgically staged endometrioid-type EC with LVSI were identified. LN involvement was detected in 88 patients (31.4%) with a systematic LN dissection. In multivariate analysis, elevated baseline serum CA 125 levels, deep myometrial invasion (MMI), adnexal involvement and positive peritoneal cytology were found to be independent risk factors for LN metastasis. In women without deep MMI and elevated baseline serum CA 125 levels, the rate of LN metastasis was 19%. The presence of solely deep MMI increased this probability up to 29.1%. The rate of LN metastasis was found to be 46.8% for women with both deep MMI and elevated baseline serum CA 125 levels. Conclusion: These findings may be useful in the decision- making process for LVSI-positive women who are unstaged. (c) 2018 S. Karger GmbH, Freiburg