Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item The African Variant of BKV in A Turkish Renal Transplant Patient(2014) Colakoglu, Sule; Dursun, Hasan; Cengiz, Nurcan; Bulat, Meryem Cosar; Noyan, Aytul; https://orcid.org/0000-0002-8817-494X; 24726687; AAB-7105-2020; GPX-7059-2022; AAD-5713-2021In renal transplant recipients, BK polyomavirus (BKV) is linked to nephropathy. BK virus genotypes have a strong geographic component. This paper presents the African variant of BKV in a Turkish renal transplant patient, which is a rare cause of infection in the Northern Hemisphere and, to our knowledge, the first case from Turkey. (C) 2014 Elsevier Inc. All rights reserved.Item Pediatric Renal Transplantation: A Single Center Experience(2015) Dursun, Hasan; Cengiz, Nurcan; Noyan, Aytul; Caliskan, Kenal; Basturk, Bilkay; Yildirim, Sedat; Moray, Gokhan; Baskin, Esra; Haberal, Mehmet; 0000-0002-5735-4315; 0000-0002-8817-494X; 0000-0003-2498-7287; 0000-0002-3462-7632; 0000-0003-4361-8508; 0000-0002-8784-1974; AAF-4610-2019; AAB-7105-2020; AAE-1041-2021; AAJ-8097-2021; AAD-5713-2021; B-5785-2018; AAD-6918-2021Item Prevalence of Hypertension in Children and Adolescents with Unclassified Headache(2015) Dursun, Hasan; Saygi, Semra; Cengiz, Nurcan; Savas, Tulin; Erol, Ilknur; Noyan, Aytul; 0000-0002-8817-494X; 0000-0002-3530-0463; 0000-0002-8522-5078; AAB-7105-2020; AAK-4825-2021; AAD-5713-2021; AAB-1203-2021Item Potentially Reversible Encephalopathy in Children with Chronic Renal Failure(2015) Dursun, Hasan; Cengiz, Nurcan; Saygi, Semra; Alkan, Ozlem; Savas, Tulin; Noyan, Aytul; 0000-0002-8817-494X; 0000-0001-7526-3460; 0000-0002-8522-5078; AAB-7105-2020; AAM-4169-2021; AAB-1203-2021; AAD-5713-2021Item Urinary Ngal, Kim-1 and L-fabp Levels in Patients with Vesicoureteral Reflux(2014) Parmaksiz, Gonul; Noyan, Aytul; Dursun, Hasan; Ince, Emine; Anarat, Ruksan; Cengiz, Nurcan; https://orcid.org/0000-0003-2373-1837; https://orcid.org/0000-0002-8817-494X; AAM-2935-2021; AAD-5713-2021; AAB-7105-2020Item Urinary Ngal, Kim-1 and L-fabp Levels in Antenatal Hydronephrosis(2014) Dursun, Hasan; Noyan, Aytul; Parmaksiz, Gonul; Ezer, Semire Serin; Anarat, Ruksan; Cengiz, Nurcan; https://orcid.org/0000-0002-8817-494X; https://orcid.org/0000-0003-2373-1837; AAW-8783-2020; AAD-5713-2021; AAM-2935-2021; AAJ-9529-2021Item Value of Sonographic Anterior-Posterior Renal Pelvis Measurements Before and After Voiding for Predicting Vesicoureteral Reflux in Children(2015) Demir, Senay; Tokmak, Naime; Cengiz, Nurcan; Noyan, Aytul; 0000-0002-4209-9075; 25545034; GPX-7059-2022; AAD-5713-2021; AAK-9310-2021PurposeVoiding cystourethrography (VCUG) is the gold standard for diagnosing vesicoureteral reflux (VUR), but it is important to minimize the use of VCUG because of the urinary catheterization and radiation exposure required. Ultrasound (US) observations suggest that pelvicalyceal dilatation varies according to the degree of bladder fullness in children with urinary tract infection. The aim of this study was to assess whether anterior-posterior (AP) measurements of the renal pelvis on US before and after voiding can be used as a screening tool while predicting the presence of VUR in children. MethodsThe subjects were toilet-trained children older than 4 years who required VCUG. Two groups were established based on the VCUG results: a VUR group of 40 kidney units (each unit defined as calyces and ureter) that exhibited different severities of reflux, and a control group of 68 kidney units unaffected by VUR. Prior to VCUG, US AP measurements of the renal pelvis of each kidney unit were recorded when the urinary bladder was full and again after bladder emptying. The change in AP measurement from before to after voiding was compared between the two groups. ResultsThe mean change in AP measurements from before to after voiding in the VUR group was significantly greater than that in the control group (p=0.003). ConclusionsComparing US AP measurements of the renal pelvis before and after voiding is useful for identifying children who are suspected to have VUR and thus require immediate VCUG. (c) 2014 Wiley Periodicals, Inc. J Clin Ultrasound 43:490-494 2015Item Urinary NGAL, KIM-1 and L-FABP Concentrations in Antenatal Hydronephrosis(2015) Noyan, Aytul; Parmaksiz, Gonul; Dursun, Hasan; Ezer, Semire Serin; Anarat, Ruksan; Cengiz, Nurcan; 0000-0002-8817-494X; 0000-0003-2373-1837; 0000-0002-9597-3264; 26096437; AAJ-9529-2021; AAB-7105-2020; AAD-5713-2021; AAW-8783-2020; GPX-7059-2022; AAM-2935-2021The clinical tests currently in use for obstructive nephropathy (such as renal ultrasonography, differential radionuclide renal scans and urinary creatinine concentration data) are not efficient predictors of the subsequent clinical course. Novel and simple biomarkers are required which, if proven, could be clinically beneficial in determining if a patient is eligible for surgery or reno-protective therapy. More recently, the interest of clinicians has focused on the potential of urinary neutrophil gelatinase-associated lipocalin (uNGAL), urinary kidney injury molecule-1 (uKIM-1) and urinary liver-type fatty acid-binding proteins (uL-FABP) as biomarkers for renal function in children with hydronephrosis (HN). Objective The purpose of this study was to investigate possible clinical applications of uNGAL, uKIM-1 and uL-FABP as beneficial non-invasive biomarkers to determine whether or not surgical intervention is required in children with HN. Study design Renal ultrasonography and radionuclide renal scans were used as diagnostic tools to detect HN. Patients were divided into two groups based on the anteroposterior diameter of their renal pelvis and the presence of dysfunction. Group 1 included 26 children with severe HN (with dysfunction), and group 2 consisted of 36 children with mild HN (without dysfunction). Urine samples were collected from 62 children with HN and 20 healthy children. Results Hydronephrosis was more common in males than in females, with a male to female ratio of 9: 1 in the study sample. The incidence of left kidney involvement (32 patients) was slightly higher than right kidney involvement (28 patients). Compared with controls and group 2, the ratio of uNGAL to creatinine was significantly higher in group 1 (p < 0.05). The biomarker uNGAL/Cr exhibited fairly good diagnostic accuracy, with an area under the curve of 0.68 [95% confidence interval 0.6-0.7] and an optimal cut-off value of 0.16 ng/mg Cr (sensitivity 58%, specificity 75%) (p < 0.05). There was a positive correlation between the uNGAL/Cr ratio and the uKIM-1/Cr ratio (r = 0.582, p < 0.05) and uL-FABP/Cr ratio (r = 0675, p < 0.05) in group 1. Discussion The results clearly demonstrated that children with hydronephrosis and dysfunction had significantly increased uNGAL, and uNGAL/Cr concentrations. However, uKIM-1, uKIM-1/Cr, uL-FABP and uL-FABP/Cr concentrations were not significantly different when compared with controls. These results support the use of uNGAL concentrations as an early marker for renal dysfunction in HN. Conclusions The study clearly demonstrated that pediatric patients with hydronephrosis and dysfunction had significantly higher uNGAL to creatinine concentrations as compared with controls.Item Role of New Biomarkers for Predicting Renal Scarring in Vesicoureteral Reflux: NGAL, KIM-1, And L-FABP(2016) Parmaksiz, Gonul; Noyan, Aytul; Dursun, Hasan; Ince, Emine; Anarat, Ruksan; Cengiz, Nurcan; https://orcid.org/0000-0003-2373-1837; 26324091; AAM-2935-2021; AAD-5713-2021; AAW-8783-2020Reflux nephropathy is the most serious complication of vesicoureteral reflux (VUR). The aim of this study was to assess the role of urinary levels of neutrophil-gelatinase-associated lipocalin (NGAL),kidney injury molecule-1 (KIM-1), and liver-type fatty-acid-binding protein (L-FABP) in the early diagnosis of reflux nephropathy in patients with VUR. This study assessed 123 patients with primary VUR and 30 healthy children as a control group. The children were divided into five groups: Group A, patients with VUR and renal parenchymal scarring (RPS); Group B, patients with VUR and without RPS; Group C, patients with RPS and resolved VUR; Group D, patients with resolved VUR and without RPS; Group E, healthy reference group. Median urinary NGAL (uNGAL)/Creatinine (Cr) was significantly higher in patients with than those without RPS and the control group (p = 0.0001). Median uKIM-1/Cr was similar in all groups (p = 0.417). Median uL-FABP/Cr was significantly higher in patients with RPS than in the reference group (p < 0.05). Urinary NGAL levels may be used as a noninvasive diagnostic marker for predicting renal scarring in reflux nephropathy.Item Genotypic and Phenotypic Features of the Cystinosis Patients from the South Eastern Part of Turkey(2016) Onenli-Mungan, Neslihan; Kor, Deniz; Karabay-Bayazit, Aysun; Cengiz, Nurcan; Yavuz, Sevgi; Noyan, Aytul; Ceylaner, Gulay; Seker Yilmaz, Berna; Topaloglu, Ali Kemal; Yuksel, Bilgin; Anarat, Ali; 28276207; GPX-7059-2022We have conducted this study for the purposes of demonstrating the spectrum of mutations and of identifying their effects on the phenotype, with a particular focus on the clinical course, prognosis and response to treatment. A total of 25 patients from 20 families, who have been treated and followed up after being diagnosed with cystinosis. Nine patients were identified with mutations of homozygous c. 451A>G, 7 patients with homozygous c. 681G>A, 6 patients with homozygous c. 834_842del, 2 patients with homozygous c. 18_21delGACT and 1 patient with compound heterozygous for c. 451A>G/c. 1015G>A. The c. 834_842del mutation identified in six patients from four families has not been previously identified. Progression to renal failure occurred earlier in the patients identified with the new mutation, despite treatment. Larger patient series are required to demonstrate the genotypic properties of the patients with cystinosis and their relationship with the clinical course.