Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Author: search.filters.author.Bozca, RecepHas files: Yes

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    Comparison of Helical and TomoDirect Techniques with Simultaneous Integrated Boost in Early Breast Cancer Patients
    (REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 2023) Onal, Cem; Bozca, Recep; Oymak, Ezgi; Guler, Ozan Cem
    Background: The aim of the study was to perform dosimetric comparisons of helical (H) and TomoDirect (TD) plans for whole-breast irradiation (WBI) with simultaneous integrated boost (SIB) in early-stage breast cancer patients undergoing breast conserving surgery.Materials and methods: Fifty patients, 25 with left-side and 25 with right-side tumors, were determined for a treatment planning system for a total dose of 50.4Gy in 1.8Gy per fraction to WBI, with a SIB of 2.3Gy per fraction delivered to the tumor bed. The planning target volume (PTV) doses and the conformity (CI) and homogeneity indices (HI) for PTV(breast )and PTVboost, as well as organ-at-risk (OAR) doses and treatment times, were compared between the H and TD plans.Results: All plans met the PTV coverage criteria for the H plan, except for mean V107 of PTVbreast for TD plan. The H plan yielded better homogeneity and conformity of dose distribution compared to the TD plan. The ipsilateral mean lung doses were not significantly different between the two plans. The TD plans is advantageous for mean doses to the heart, contralateral breast and lung, spinal cord, and esophagus than the H plans. In both the H and TD plans, the right-sided breast patients had lower heart dose parameters than the left-sided breast patients. The TD plan is superior to the H plan in sparing the contralateral breast and lung by decreasing low-dose volumes.Conclusions: While the OAR dose advantages of TD are appealing, shorter treatment times or improved dose homogeneity and conformity for target volume may be advantageous for H plan.
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    The Comparison of Helical-IMRT, Direct-IMRT and 3D Radiotherapy Modalities in Breast Radiotherapy Planning
    (2020) Erdis, Eda; Yucel, Birsen; Ozyurek, Betul; Bozca, Recep
    OBJECTIVE This study aims to compare dosimetric 3D-CRT, Tomo-helical mu and Direct IMRT methods in intact breast irradiation. METHODS Radiotherapy was planned with three different techniques simulated images of 30 breast cancer patients with negative lymph nodes who underwent breast-conserving surgery. RESULTS The maximum and minimum doses, homogeneity and conformity index and cold-zone volumes were found to be different in all three techniques (p<0.001). The PTV boost maximum doses and homogeneity index were found to be different (p<0.001). The maximum non-PTV dose (110% volume) and the hot zone volumes grasped by these doses, the V5 volume of the body and V5 volumes, outer of PTV were found to be statistically significant for all three techniques (p<0.001). A statistically significant difference was found between the three techniques concerning the ipsilateral lung V5 and V20 volumes, the contralateral lung V5 and V10 volumes and the counter breast maximum and mean doses (p<0.001). The mean and V10 volume of the heart was statistically significant (p<0.001), while the left breast irradiation and mean values were not statistically significant between the three techniques (p=0.529). However, there was a statistically significant difference in the V10 volume of the left breast irradiation between the three techniques (p=0.033). CONCLUSION According to 3D-CRT, it is possible to achieve better dose distribution and dose homogeneity with Tomo-helical and direct IMRT. Low dose volumes arc high with tomo-helical IMRT. Torno-helical IMRT planning provides better ipsilateral lung and heart doses but causes an increase in heart dose/contralatcral breast and for right breast irradiation causes an increase in heart dose