Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Author: search.filters.author.Bildaci, Tevfik BerkSubject: search.filters.subject.gestational diabetes

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    Measuring Visfatin Levels in Saliva: An Alternative Approach to Gestational Diabetes Screening
    (2021) Bildaci, Tevfik Berk; 34762778
    Objective: Oral glucose tolerance testing (OGTT) is the current recommended approach for the diagnosis of gestational diabetes mellitus (GDM). Visfatin is a type of novel adipokine of interest that mostly participates in glucose metabolism and inflammatory processes. We aim to identify a screening technique for GDM using salivary visfatin levels and to establish this technique's value as a screening method compared to OGTT. Materials and methods: This is a cross-sectional case-control study.The cohort was formed from the saliva samples of pregnant patients in their 24th through 28th weeks of gestation. Patients were divided into two groups depending on their GDM status. OGTT and visfatin test results were compared and subjected to further analysis to establish a cutoff value for visfatin testing. Results: ELISA results indicated a significant difference between patients with GDM compared to patients without GDM; the values were 18.89 +/- 9.59 and 12.44 +/- 8.75, respectively (p: 0.007). A cutoff value of 10.5 ng/mL can be used to detect GDM with 78% sensitivity and 51% specificity. Conclusion: Salivary visfatin levels were significantly higher in patients with GDM. The existence of a differential in the concentration of visfatin in saliva can be utilized to develop a new screening method for GDM.
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    Salivary Leptin and Chemerin; a novel way of gestational diabetes screening
    (2020) Okten, Sabri Berkem; Bildaci, Tevfik Berk; 0000-0001-7473-761X; 32274942
    Introduction: Oral glucose tolerance testing (OGTT) is the recommended approach for the diagnosis of gestational diabetes mellitus (GDM). Leptin and chemerin are two examples of hormones from adipokine family, which mostly takes part in glucose metabolism and inflammatory processes. We aim to find a possible new and tolerable screening technique for GDM using salivary levels of leptin and chemerin. Material and method: Saliva samples of pregnant patients, on their 24-28th weeks of gestation, are collected via saliva collection kit. Leptin and chemerin ELISA tests were run from serum samples being hold at -80 degrees C following their thawing session. Patients are divided into two groups depending on their GDM status. OGTT results of patients are compared with their ELISA results. Results: ELISA study for leptin showed an insignificant difference between patients with GDM and patients without where the values were 0.44 +/- 0.33 and 0.34 +/- 0.24 respectively (p: 0.155). Chemerin study revealed a significant difference between patients with GDM and without 631.06 +/- 344.42, 334.81 +/- 244.91 respectively (p < .001). Conclusion: Leptin and chemerin can be detected in saliva. Chemerin levels are significantly higher in patients with GDM, thus this knowledge can be used to develop a new screening method for OGTT.