Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Author: search.filters.author.Aydin, Leylasearch.filters.applied.f.rights: search.filters.rights.info:eu-repo/semantics/openAccess

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    An Alternative Low-Cost Solution for Tracking Laboratory Animals
    (2020) Kiziltan, Erhan; Aydin, Leyla; 0000-0001-6029-3835; AAD-6090-2021
    Objectives: Monitoring animal behavior under various conditions can provide important information on their neuropsychological status, including learning, memory, and cognitive activity. Several commercial tracking systems are available, but they may be too expensive for low-budget projects. This study developed an alternative solution for automated animal tracking in behavioral experiments. Methods: The proposed system was designed to analyze a set of images sampled from a recorded video file in chronological order. The instantaneous location of the animal in each image frame was defined automatically, using a feature-extraction algorithm. Distances traveled were calculated using the coordinates of the successive instantaneous locations. The algorithm was tested using two arenas: the Morris water maze and open field test. The calculated measures were compared with those obtained manually. The internal consistency of the dataset was checked using Cronbach's alpha. The accuracy of the results was evaluated using the paired samples t-test and Pearson correlation, with the level of statistical significance set at p<0.01. Results: A statistical comparison of the distances traveled, which were derived from the coordinates of successive locations, did not differ significantly between the manual and automatic methods (r=0.954 and p=0.792 for the Morris water maze; r=0.996 and p=0.024 for the open field test). Conclusions: These results suggest that the algorithm is reliable and valid for estimating coordinates and may serve as a high-resolution tool for animal behavior experiments. We intend to make this software freely available to interested readers and to open feedback channels for further development.
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    The Impacts of Central Fatigue on the Polyphasic Nature of Tapping Performance
    (2018) Kiziltan, Erhan; Aydin, Leyla; Ogus, Ersin; Azizagaoglu, Bahadir; Buyukkaraman, Arda; Doga, Selen; Ertuk, Gizem; Kus, Cansel; 0000-0002-9877-421X; 0000-0001-6029-3835; AAJ-1058-2021; ABC-5392-2020; AAD-6090-2021
    Objective: As a non-specific symptom muscle fatigue mostly accompanies neuromuscular diseases and also occurs frequently in healthy individuals. Fatigue phenomenon is considered to be multidimensional symptom. There have been still discussions on the origin whether it depends primarily on the intrinsic properties of muscle itself (peripheral mechanisms) or the nervous system that controls muscle (central mechanisms). This study aimed to investigate the effects of central fatigue on the performance of maximal voluntary repetitive movement and discusses the specificity of finger tapping task test as a simple diagnostic tool for fatigue. Methods: For this purpose, 27 healthy, male, right-handed volunteer performed the 20-s of finger tapping task test for four times. The one was for control and the other three were performed right after induction of three different central fatigue models. Temporal behavior of tapping performances were evaluated based on inter-tap intervals and the statistical comparison were made by regression analysis. Results: The results showed that the partial evaluation of the task in time domain instead of complete test period yielded with statistically significant differences between control and fatigue models (p<0.001) and even in between the fatigue models. Conclusion: Approximately the first 5-s of a finger tapping task consists of both motor learning processes and dynamics of energy consumption from anaerobic sources. However, it reflects dominantly the central components of fatigue. We may conclude that the temporal behavior of tapping performance following the induction of specific fatigue model may help making further discrimination for the origin of fatigue.