Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item Association between Hypoxia Parameters with White Matter Hyperintensity and Silent Cerebral Infarcts on Brain Magnetic Resonance Images in Patients with Obstructive Sleep Apnea(2016) Avci, Aynur Yilmaz; Avci, Suat; Lakadamyali, Huseyin; Lakadamyali, Hatice; Can, Ufuk; 0000-0003-2155-8014; 0000-0001-9004-9382; 0000-0001-8689-417X; O-3636-2018; F-6770-2019; AAJ-2999-2021Objective: This study evaluated the association between hypoxia parameters with white matter hyperintensity (WMH) and silent cerebral infarcts (SCI) on brain magnetic resonance (MR) images of patients with obstructive sleep apnea (OSA). Methods: In this retrospective study, the study group was composed of 453 patients who were evaluated by overnight polysomnography (PSG). Data on hypoxia parameters, such as total sleep duration with oxygen saturation < 90% (ST90), percentage of cumulative time with oxygen saturation < 90% (CT90), and the lowest oxygen saturation (min SaO(2)), were obtained from PSG. The presence of WMH and SCI was evaluated in all participants using brain MR images. Results: Hypoxia parameters, such as ST90, CT90, and min SaO(2), were significantly associated with WMH (P < 0.001). The multiple regression analysis showed that CT90 was independently associated with SCI (P = 0.038). In addition, when participants were divided into two groups according to CT90 < 10% and CT90 = 10%, age (P = 0.002), sex (P = 0.015), body mass index, Apnea-Hypopnea Index score, Epworth Sleepiness Scale score, and the presence of WMH, hypertension, and diabetes mellitus were significantly higher in the CT90 = 10% group compared with the CT90 < 10% group (P < 0.001 for all parameters). CT90 = 10% increased the risk of WMH 2.34-fold (95% confidence interval, 1.44-3.85; P = 0.006). Conclusion: The severity of nocturnal intermittent hypoxia may contribute to the pathogenesis of WMH and SCI in patients with OSA.Item Peripheral Nerve Function Changes Due to Hypoxia in Obstructive Sleep Apnea(2019) Avci, Aynur Yilmaz; Avci, Suat; 0000-0001-9004-9382Introduction: Chronic hypoxia is known to be one of the risk factors for peripheral neuropathy. However, the effect of intermittent hypoxia on peripheral nerves is not fully understood. This study evaluated the relation between intermittent hypoxia and peripheral nerve function in Obstructive Sleep Apnea (OSA) patients. Materials and Methods: In this retrospective study, 86 patients who underwent polysomnography (PSG) and electroneuromyography were enrolled. Participants with diseases affecting peripheral nerves and lung function were excluded from the study. Hypoxia parameters were obtained from the PSG study. Lower extremity motor and sensory nerve conduction studies of all patients were evaluated. Results: In patients with OSA, peroneal nerve distal motor latency and sural sensory nerve action potential amplitude was low and velocity was significantly slower than controls (p<0.001, p<0.04, p<0.001, respectively). After adjustment for age and body mass index, the results remained significantly (p<0.001, p<0.01, p<0.001, respectively). The nerve conduction results were significantly correlated with the hypoxia parameters. After adjustment for confounding factors, logistic regression analyses revealed that hypoxia parameters were independently associated with nerve conduction results. Conclusion: OSA and intermittent hypoxia may affect both motor and sensory nerve conduction, which suggests that subclinical sensorimotor peripheral neuropathy is associated with OSA. The related intermittent hypoxia and OSA may be a cause of axonal and demyelinating neuropathies.