Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

Browse

Filters

2016 - 201912020 - 20231

Settings

Author: search.filters.author.Araz, FilizHas files: Yes

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    Predictive Effects of Platelet Indices in Cirrhotic Patients with or without Portal Vein Thrombosis
    (2023) Araz, Filiz; Soydas, Baris
    Objective: Portal vein thrombosis (PVT) is a common finding in liver cirrhosis. Besides low portal blood flow, thrombophilia, bacterial translocation and endotoxemia, platelets which are considered as important source of prothrombotic agents may play a role in thrombotic events in cirrhosis. Large platelets have been reported to have numerous granules that result in greater thrombotic and proinflammatory activity. We aimed to define the role of platelet indices in PVT among cirrhotic patients. Method: Cirrhotic patients admitted to Gastroenterology Clinic and having a dynamic radiological examination were assessed retrospectively. Demographic and laboratory findings were recorded including platelet distribution width (PDW) and mean platelet volume (MPV). Severity of cirrhosis was assessed with MELD (Model for End Stage Liver Disease) and Child-Pugh-Turcotte (CPT) scores Results: Study included 255 patients. Mean age was 60.6 +/- 10.2 years. 41.6% of patients were female. 50 (19.6%) patients had PVT. Patients with PVT did not differed from those without PVT in age, gender and presence of diabetes mellitus. Median platelet count was lower in patients with PVT (100 (22-370) vs 79.5 (22-573), p: 0.033). Mean MPV and PDW levels were similar between PVT and non-PVT groups (p > 0.05). Although median MELD scores did not differ between groups, median CPT scores were significantly higher in PVT compared to non-PVT group (p:0.027). Conclusion: Cirrhotic patients with PVT had more prominent thrombocytopenia, but similar MPV and PDW levels compared to those without PVT.
  • Thumbnail Image
    Item
    The importance of salivary cortisol in the diagnosis of adrenal insufficiency in cirrhosis
    (2016) Araz, Filiz; Soydas, Baris; Ozer, Birol; Serin, Ender; 27210784
    Background/Aims: Reports on adrenal insufficiency (AI) are unexpectedly high in cirrhosis, and the diagnosis of this condition remains a challenge. We aimed to define the prevalence rate of AI in stable cirrhotic patients and determine the correlations of free cortisol and salivary cortisol with total cortisol. Materials and Methods: Between January 2011 and September 2011, 110 consecutive cirrhotic patients without any infection or hemodynamic instability were enrolled. Baseline total and salivary cortisol levels were measured. The free cortisol level was calculated according to the Coolens' formula. Post-stimulation total and salivary cortisol levels were measured, and the free cortisol level was recalculated. Results: The mean age of the patients was 62.1 +/- 11.4 years. There were 54 males (49.1%). The mean Child-Turcotte-Pugh (CTP) score was 7.2 +/- 2.3. Twenty-two (20%) patients were at the CTP-C level. AI was present in 23 (20.9%) and 17 (15.5%) of all patients according to the total and free cortisol criteria, respectively. For basal and stimulated levels, salivary cortisol rather than total cortisol correlates well with free cortisol. Conclusion: The diagnosis of AI on the basis of total cortisol measurement overestimates the prevalence of AI in cirrhosis. Salivary cortisol, which correlates well with free cortisol, is a promising alternative for the diagnosis of AI in cirrhotic patients.