Tıp Fakültesi / Faculty of Medicine
Permanent URI for this collectionhttps://hdl.handle.net/11727/1403
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Item The Relationship Between Thyroid Volume and Malignant Thyroid Disease(2014) Duran, Ayse Ocak; Anil, Cuneyd; Gursoy, Alptekin; Nar, Asli; Altundag, Ozden; Inanc, Mevlude; Bozkurt, Oktay; Tutuncu, Neslihan Bascil; https://orcid.org/0000-0003-3802-9733; https://orcid.org/0000-0003-0998-8388; https://orcid.org/0000-0003-0197-6622; https://orcid.org/0000-0002-1816-3903; 24338169; AAA-2743-2021; W-9219-2019; ABG-5027-2020The present retrospective study aimed to investigate the relationship between thyroid volume and prevalence of thyroid cancer. We investigated the data of 3,850 patients who underwent fine-needle aspiration biopsy (FNAB). Biopsy results were evaluated as diagnostic or nondiagnostic, and diagnostic results were classified as benign, malignant, and indeterminate. We included 2,672 patients who underwent FNAB firstly in our hospital and evaluated as diagnostic biopsy except subgroup of indeterminate. We obtained cytologic data, levels of serum thyroid-stimulating hormone (TSH), and thyroid volumes of those patients retrospectively. Among 2,672 patients with thyroid nodule, 2,562 (95.9 %) patients had benign cytology and 110 (%4,1) patients had malignant cytology. There was no correlation between the malignancy and gender (p = 0.935), and patients with malignant cytology were younger (52 vs 59, p < 0.001). Also, TSH levels were higher in patients with malignant than benign cytology (p = 0.017). Median volume of right part, left part, and total thyroid for patients who had malignant cytology was significantly lower than patients who had benign cytology (8.3, 7.1, 15.9 vs 10.8 ml, 9.0 mml, 20.6 ml, respectively, p <= 0.001 for all parameters). The results demonstrated that thyroid cancer prevalence was higher in patients with low thyroid volume. According to our results, thyroid volume should be considered as a risk factor for malignancy in the evaluation of thyroid nodules.Item Biomolecular Markers for Improving Management of Follicular and Medullary Thyroid Cancer(2014) Mousa, Umut; Anil, Cuneyd; Isildak, Serife Mehlika; Gursoy, Alptekin; Carpi, Angelo; https://orcid.org/0000-0002-8078-9376; https://orcid.org/0000-0003-3802-9733; https://orcid.org/0000-0002-2602-1657; I-1735-2018; AAA-4216-2021Thyroid cancer usually presents as a thyroid nodule. According to different reports, more than 95% of thyroid nodules are benign. The gold standard for preoperative diagnosis of thyroid cancer is fine-needle aspiration cytology (FNAC). Especially in diagnosing medullary thyroid carcinoma (MTC) and some cases of well-differentiated thyroid carcinomas, biomolecular markers are proposed to increase the diagnostic value of FNAC. In this chapter, we mainly focused on classification, genetics, use of biomolecular and invasive markers, as well as treatment of follicular thyroid cancer (FTC) and MTC. In the case of FTC, some molecular and immunohistochemical markers are proposed and are currently under investigation principally for improving preoperative diagnosis. Unlike MTC, there is no powerful biomarker such as calcitonin (Ct) for FTC diagnosis. In the follow-up, serum thyroglobulin (Tg) and whole-body iodine-131 scintigraphy are effective. MTC has relatively poor prognosis. Postsurgical therapy is scarcely effective. Blood Ct is the best studied and preferred marker in the diagnosis and follow-up of MTC. It can be measured in the basal state or after provocative stimuli such as pentagastrin and high-dose calcium. Carcinoembryonic antigen (CEA) and chromogranin A (CgA) are the other markers currently used for selected cases. Ct and CEA doubling times are gaining importance for the prognosis of MTC. The importance of rearranged during transfection (RET) proto-oncogene screening in MTC is also discussed in this chapter. RET has also become a therapeutic target. In conclusion, the management of FTC and MTC includes diagnostic and therapeutic problems. However, thanks to the development of translational medicine, the biomolecular marker studies are improving FTC and MTC diagnosis, prognosis, and therapy.Item The effects of hyperinsulinemia on cochlear functions(2020) Koca, Arzu Or; Koca, Huseyin Samet; Anil, Cuneyd; 33402607Context: Hyperinsulinemia is the most common metabolic change associated with cochleovestibular diseases. Aim: We aimed to investigate the auditory functions in hyperinsulinemic individuals. Settings and Design: A total of 164 patients were included in this case-control study. While 76 patients with insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] of >= 2.5) constituted the case group, 88 patients with HOMA-IR values of <2.5 constituted the control group of the study. Material and Methods: The 75 g oral glucose tolerance test, blood biochemistry tests, hormonal analysis, audiological assessment, electrocochleography (EcochG), and transient evoked otoacoustic emissions (TEOAE) testing were performed. Statistical Analysis: One-way analysis of variance and Kruskal-Wallis analysis of variance were used for the comparison of the metabolic and ear parameters in the normal glucose tolerance (NGT), impaired fasting glucose (IFG), and impaired glucose tolerance (IGT) groups. The chi-square test was used to compare nominal variables. Spearman and Pearson correlation coefficients were used for the correlation analyses of continuous variables. Results: The pure tone audiometry at 0.5, 1, 2, and 4 kHz was better in the case group than in the control group. A positive correlation was found between HbA1c and right ear 0.5, 1, 4, and 8 kHz threshold values and left ear 2, 4, 6, and 8 kHz threshold values. A negative correlation was found between HbA1c and speech discrimination scores. The right ear 1.00 and 2.83 kHz TEOAE measurements in the individuals with NGT were found higher than those in patients with IGT, and the 1.42 kHz TEOAE measurements and reproducibility were found higher than those in patients with IFG. The left ear 1.00 and 1.42 kHz TEOAE measurements of the IGT patients were found lower than those of IFG and NGT patients. Conclusion: We showed that hearing was worsening in hyperinsulinemic patients and prediabetic conditions were related to hearing function impairment.