Tıp Fakültesi / Faculty of Medicine

Permanent URI for this collectionhttps://hdl.handle.net/11727/1403

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Author: search.filters.author.Akkucuk, Mehmet HusamettinHas files: No

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    Migraine and Subclinical Atherosclerosis: Endothelial Dysfunction Biomarkers and Carotid Intima-Media Thickness: A Case-Control Study
    (2019) Avci, Aynur Yilmaz; Akkucuk, Mehmet Husamettin; Torun, Ebru; Arikan, Serap; Can, Ufuk; Tekindal, Mustafa Agah; https://orcid.org/0000-0001-9004-9382; https://orcid.org/0000-0003-4569-1143; https://orcid.org/0000-0001-5752-3812; https://orcid.org/0000-0001-8689-417X; https://orcid.org/0000-0002-4060-7048; 30645751; F-6770-2019; AAJ-2828-2021; AAJ-1289-2021; AAJ-2999-2021; U-9270-2018
    Background Migraine is a common neurovascular disease associated with vascular risks, especially in young adult females, but the mechanism underlying these associations remains unknown. This study evaluated the relationships between plasma endothelial dysfunction biomarkers and carotid intima-media thickness (IMT) in young adult females with migraine. Methods This case-control study included 148 female patients (age range: 18-50years). Migraine was diagnosed according to the International Headache Society-IIIb criteria. Endothelial dysfunction biomarkers, such as von Willebrand factor (vWF), C-reactive protein (CRP), homocysteine, total nitrate/nitrite concentration, and thiobarbituric acid-reactive substances (TBARS), were evaluated in plasma. Carotid IMT was measured by a radiologist with sonography. Results The CRP, TBARS, vWF, and IMT levels were increased in the migraine compared with the control group (p<0.001, p=0.02, p<0.001, and p<0.001, respectively). After adjusting for confounders, multiple linear regression analysis revealed that systolic arterial blood pressure, CRP, vWF, TBARS, and right and left internal carotid artery (ICA) IMT were independently positively correlated with migraine (p<0.01, p=0.004, p=0.023, p=0.024, p=0.032, and p=0.048, respectively). Multiple logistic regression analysis revealed that right ICA IMT was independently associated with ergotamine and triptan and left ICA IMT was independently associated with ergotamine (p=0.013, p=0.026, and p=0.017, respectively). In addition, significant correlations were found between LDL lipoprotein and carotid IMT in the migraine group (p<0.05). Conclusions Carotid IMT enhancement and elevated TBARS, vWF, and CRP levels in migraine subjects during a migraine attack could be regarded as consequences of migraine attack pathophysiology. The independent associations between triptan and ergotamine consumption and enhanced carotid IMT suggest that repeated use of these vasoconstrictive antimigraine agents may have additional effects on carotid IMT.
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    Does measles immunization lead to immunization for COVID-19? Case series
    (2021) Akkucuk, Mehmet Husamettin; Akalin, Nalan; Gulalp, Betul; https://orcid.org/0000-0003-4569-1143; https://orcid.org/0000-0002-2045-2771; AAJ-2828-2021; P-6931-2016
    There are many studies on protective, preventive and treatment methods for about Covid-19 pandemic, which affects the whole world.The results of epidemiological studies also guide these researches. The studies of the scientists who are struggling with this pandemic worldwide reveal that the incidence of covid-19 is low in the child age group and the disease survived more mildly in childhood. There is an opinion about the reason why covid-19 disease is seen less frequently and milder in pediatric patients, that active immunization created with childhood vaccines. For this reason, we compared the Rubeola immunoglobulin levels formed aganist the measles vector, one of the childhood vaccines which has antigenic similarity with the SARS-CoV family, in patients diagnosed with covid-19 in our hospital and Rubeola immunoglobulin levels of screening performed in healthy individuals before pandemi. As a result , we found the measles IgG levels were statistically significantly higher in patients diagnosed with measles IgG covid-19 compared to the control group. According to this result, this significant increase in level after being infected with SARS-CoV2 in patients with measles immunization may have positive effects on the course of the disease. In addition. we saw that all our Covid-19 patients with high measles antibody recovered without serious mortality and morbidity , despite their age, gender and chronic diseases. Therefore , considering the completion process of vaccination studies, we think that measles vaccination can be applied to risky groups without contraindications to reduce the existing destructive effects of the disease.