The differences in the expression of fractalkine and its receptor in conditions of tonsillar hypertrophy and chronic tonsillitis

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dc.contributor.authorHetemoglu, Elif Koclu
dc.contributor.authorBabakurban, Seda Turkoglu
dc.contributor.authorTerzi, Yunus Kasim
dc.contributor.authorSahin, Feride Iffet
dc.contributor.authorErbek, Selim Sermed
dc.contributor.orcID0000-0001-5612-9696en_US
dc.contributor.orcID0000-0001-7308-9673en_US
dc.contributor.pubmedID30554983en_US
dc.contributor.researcherIDB-4372-2018en_US
dc.contributor.researcherIDAAC-7232-2020en_US
dc.date.accessioned2020-12-24T08:30:09Z
dc.date.available2020-12-24T08:30:09Z
dc.date.issued2019
dc.description.abstractObjective: Fractalkine, member of chemokine family, is involved in many inflammatory processes in the human body. The aim of this study is to compare expression levels of fractalkine ligand and its receptor in chronic tonsillitis and hypertrophic tonsil samples. Methods: The study was conducted at Baskent University Departments of Otorhinolaryngology and Medical Genetics. It is designed as a prospective, non-randomized, controlled clinical study. Total 97 samples, obtained from adenotonsillectomy due to chronic tonsillitis or tonsillar hypertrophy, were participated in the study. Fractalkine and its receptor expression levels were determined and comparison was made between the tissue groups. c.839C > T (T280 M) polymorphism of fractalkine receptor was analyzed, then relationship between polymorphism and the expression level of fractalkine receptor was investigated. Results: Fractalkine receptor expression was significantly higher in the hypertrophic tonsil group than chronic tonsillitis group (p < 0.05). Conclusion: Fractalkine, member of chemokine family, and its receptor may play role in preventing chronic-recurrent tonsillitis. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.identifier.endpage569en_US
dc.identifier.issn0385-8146en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85058224008en_US
dc.identifier.startpage565en_US
dc.identifier.urihttp://hdl.handle.net/11727/5141
dc.identifier.volume46en_US
dc.identifier.wos000477790500012en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.anl.2018.12.001en_US
dc.relation.journalAURIS NASUS LARYNXen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic tonsillitisen_US
dc.subjectHypertrophic tonsilen_US
dc.subjectFractalkine expressionen_US
dc.titleThe differences in the expression of fractalkine and its receptor in conditions of tonsillar hypertrophy and chronic tonsillitisen_US
dc.typearticleen_US

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