Evaluation of the Effects of Low-Level Laser Therapy on Diabetic Bone Healing

dc.contributor.authorDiker, Nurettin
dc.contributor.authorAytac, Duygu
dc.contributor.authorHelvacioglu, Fatma
dc.contributor.authorDagdelen, Cansu
dc.contributor.authorOguz, Yener
dc.contributor.pubmedID31232987en_US
dc.date.accessioned2020-10-12T12:32:41Z
dc.date.available2020-10-12T12:32:41Z
dc.date.issued2019
dc.description.abstractThe aim of the present study was to evaluate the effects of low-level laser therapy (LLLT) and biphasic alloplastic bone graft material on diabetic bone healing. Induction of diabetes was performed in 14 male Sprague-Dawley rats by intraperitoneal injection of a 50 mg/kg dose of streptozotocin. Two bilaterally symmetrical non-critical-sized bone defects were created in the parietal bones in each rat. Right defects were filled with biphasic alloplastic bone graft. Rats were randomly divided into 2 groups, with 1 group receiving 10 sessions of LLLT (GaAlAs, 78.5 J/cm(2), 100mW, 0.028 cm(2) beam). The LLLT was started immediately after surgery and once every 3 days during postoperative period. At the end of treatment period, new bone formation and osteoblast density were determined using histomorphometry. Empty (control), graftfilled, LLLT-treated and both graft-filled and LLLT-treated bone defects were compared. New bone formation was higher in the graft treatment samples compared with the control (P = 0.009) and laser samples (P = 0.029). In addition, graft-laser combination treatment samples revealed higher bone formation than control (P = 0.008) and laser (P = 0.026) samples. Osteoblast density was significantly higher in the laser treatment (P < 0.001), graft treatment (P = 0.001) and graft-laser combination treatment (P < 0.001) samples than control samples. In addition, significantly higher osteoblast density was observed in the graft-laser combination treatment samples compared to the graft treatment samples (P = 0.005). The LLLT was effective to stimulate osteoblastogenesis but failed to increase bone formation. Graft augmentation for treatment of bone defects seems essential for proper bone healing in diabetes, regeneration may be supported by the LLLT to enhance osteoblastogenesis.en_US
dc.identifier.endpage1998en_US
dc.identifier.issn1049-2275en_US
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85072848953en_US
dc.identifier.startpage1994en_US
dc.identifier.urihttp://hdl.handle.net/11727/4849
dc.identifier.volume30en_US
dc.identifier.wos000500374200062en_US
dc.language.isoengen_US
dc.relation.isversionof10.1097/SCS.0000000000005654en_US
dc.relation.journalJOURNAL OF CRANIOFACIAL SURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone healingen_US
dc.subjectdiabetesen_US
dc.subjectlow-level laser therapyen_US
dc.titleEvaluation of the Effects of Low-Level Laser Therapy on Diabetic Bone Healingen_US
dc.typearticleen_US

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: