Comparison Of Ceftazidime-Avibactam Susceptibility Testing Methods Against OXA-48-Like Carrying Klebsiella Blood Stream Isolates

dc.contributor.authorIsler, Burcu
dc.contributor.authorVatansever, Cansel
dc.contributor.authorOzer, Berna
dc.contributor.authorCinar, Gule
dc.contributor.authorAslan, Abdullah Tarik
dc.contributor.authorStewart, Adam
dc.contributor.authorSimos, Peter
dc.contributor.authorFalconer, Caitlin
dc.contributor.authorBauer, Michelle J.
dc.contributor.authorForde, Brian
dc.contributor.authorHarris, Patrick
dc.contributor.authorSimsek, Funda
dc.contributor.authorTulek, Necla
dc.contributor.authorDemirkaya, Hamiyet
dc.contributor.authorMenekse, Sirin
dc.contributor.authorAkalinj, Halis
dc.contributor.authorBalkan, Ilker Inanc
dc.contributor.authorAydin, Mehtap
dc.contributor.authorTigen, Elif Tukenmez
dc.contributor.authorDemir, Safiye Koculu
dc.contributor.authorKapmaz, Mahir
dc.contributor.authorKeske, Siran
dc.contributor.authorDogan, Ozlem
dc.contributor.authorArabaci, Cigdem
dc.contributor.authorYagci, Serap
dc.contributor.authorHazirolan, Gulsen
dc.contributor.authorBakir, Veli Oguzalp
dc.contributor.authorGonen, Mehmet
dc.contributor.authorSaltoglu, Nese
dc.contributor.authorAzap, Alpay
dc.contributor.authorAzap, Ozlem
dc.contributor.authorAkova, Murat
dc.contributor.authorErgonul, Onder
dc.contributor.authorPaterson, David L.
dc.contributor.authorCan, Fusun
dc.contributor.pubmedID35843111en_US
dc.date.accessioned2022-12-21T07:57:18Z
dc.date.available2022-12-21T07:57:18Z
dc.date.issued2022
dc.description.abstractCeftazidime-avibactam exhibits good in vitro activity against carbapenem resistant Klebsiella carrying OXA-48-like enzymes. We tested two hundred unique carbapenem resistant Klebsiella blood stream isolates (71% with single OXA-48-like carbapenemases, including OXA-48, n = 62; OXA-232, n = 57; OXA-244, n = 17; OXA-181, n = 5) that were collected as part of a multicentre study against ceftazidime-avibactam using Etest (bioMerieux, Marcyl'Etoile, France), 10/4 mg disc (Thermo Fisher) and Sensititre Gram Negative EURGNCOL Plates (Lyophilized panels, Sensititre, Thermo Fisher) with the aim of comparing the performances of the Etest and disc to that of Sensititre. Ceftazidime-avibactam MIC50/90 was 2/> 16 mg/L for the entire collection and was 2/4 mg/L for single OXA-48-like producers. Categorical and essential agreements between the Etest and Sensititre were 100% and 97%, respectively. Categorical agreement between the disc and Sensititre was 100%. Etest and 10/4 mg discs are suitable alternatives to Sensititre for ceftazidime-avibactam sensitivity testing for OXA-48-like producers. (C) 2022 Elsevier Inc. All rights reserved.en_US
dc.identifier.issn0732-8893en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85134757073en_US
dc.identifier.urihttp://hdl.handle.net/11727/8390
dc.identifier.volume104en_US
dc.identifier.wos000831189700002en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.diagmicrobio.2022.115745en_US
dc.relation.journalDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCeftazidime-avibactamen_US
dc.subjectCarbapenemresistantKlebsiellaen_US
dc.subjectOXA-48-likeen_US
dc.subjectOXA-232en_US
dc.subjectSensititreplateen_US
dc.subjectEtesten_US
dc.titleComparison Of Ceftazidime-Avibactam Susceptibility Testing Methods Against OXA-48-Like Carrying Klebsiella Blood Stream Isolatesen_US
dc.typearticleen_US

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