Evaluation of extensively drug-resistant gram-negative bacteremia among solid-organ transplant recipients: a multicenter study

dc.contributor.authorYanik Yalcin, Tugba
dc.contributor.authorAzap, Ozlem
dc.contributor.authorKose, Adam
dc.contributor.authorBayindir, Yasar
dc.contributor.authorSaricaoglu, Elif Mukime
dc.contributor.authorCinar, Gule
dc.contributor.authorUygun Kizmaz, Yesim
dc.contributor.authorKursun, Ebru
dc.contributor.authorAliskan, Hikmet Eda
dc.contributor.authorTezer Tekce, Yasemin
dc.contributor.authorEren Kutsoylu, Oya Ozlem
dc.contributor.authorEgeli, Tufan
dc.contributor.authorAri, Alpay
dc.contributor.authorAlbayrak, Yurdagul
dc.contributor.authorCabadak, Hatice
dc.contributor.authorDeniz, Secil
dc.contributor.authorDemir Onder, Kubra
dc.contributor.authorKizilates, Filiz
dc.contributor.authorOzger, Selcuk
dc.contributor.authorGuzel Tunccan, Ozlem
dc.contributor.authorHaberal, Mehmet
dc.contributor.orcID0000-0001-9060-3195en_US
dc.contributor.orcID0000-0002-3462-7632en_US
dc.contributor.pubmedID33865241en_US
dc.contributor.researcherIDAAE-2282-2021en_US
dc.contributor.researcherIDAAJ-8097-2021en_US
dc.date.accessioned2022-08-24T13:01:44Z
dc.date.available2022-08-24T13:01:44Z
dc.date.issued2021
dc.description.abstractBackground/aim: The aim of this study is to evaluate the distribution, sources, clinical features, and mortality rates of bacteremia due to evaluation of extensively drug-resistant (XDR) gram negative among solid-organ transplant (SOT) recipients. Materials and methods: A retrospective study of SOT recipients with bacteremia due to XDR gram-negative pathogens in 11 centers between 2016 and 2018 was conducted. Patients' records were evaluated. Results: Of 171 bacteremia that occurred in 164 SOT recipients, 93 (56.7%) were liver, 46 (28%) kidney, 14 (8.5%) heart, and 11 (6.7%) lung recipients. Bacteremia episodes were recorded in the first year in 63.7% of the patients (n = 109), early-onset bacteremia was recorded in 45% (n = 77) of the episodes. In multivariate analysis, catheter-associated bacteremia was an independent risk factor for 7-day mortality (p = 0.037), and early-onset bacteremia was found as an independent risk factor for 30-day mortality (p = 0.017). Conclusion: Difficult-to-treat infections due to XDR bacteria in SOT recipients shadow the success of transplantation. Central venous catheters seem to be the main risk factor. Judicious use of medical devices is of pivotal importance.en_US
dc.identifier.endpage1968en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85114851700en_US
dc.identifier.startpage1960en_US
dc.identifier.urihttp://hdl.handle.net/11727/7404
dc.identifier.volume51en_US
dc.identifier.wos000691544700047en_US
dc.language.isoengen_US
dc.relation.isversionof10.3906/sag-2101-161en_US
dc.relation.journalTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSolid-organ transplant recipientsen_US
dc.subjectdrug-resistanten_US
dc.subjectbacteremiaen_US
dc.titleEvaluation of extensively drug-resistant gram-negative bacteremia among solid-organ transplant recipients: a multicenter studyen_US
dc.typearticleen_US

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