The Role of Combined Diffusion-Weighted Imaging and Dynamic Contrast-Enhanced MRI for Differentiating Malignant From Benign Breast Lesions Presenting Washout Curve

dc.contributor.authorTezcan, Sehnaz
dc.contributor.authorOzturk, Funda Ulu
dc.contributor.authorUslu, Nihal
dc.contributor.authorAkcay, Eda Yilmaz
dc.contributor.pubmedID32157892en_US
dc.date.accessioned2022-08-29T13:04:43Z
dc.date.available2022-08-29T13:04:43Z
dc.date.issued2021
dc.description.abstractPurpose: The aim of this study is to evaluate the diagnostic performance of combined breast magnetic resonance imaging (MRI) protocol including dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) in patients with enhancing lesions that demonstrated washout curve and to determine whether applying apparent diffusion coefficient (ADC) cutoff value could improve the diagnostic value of breast MRI. Methods: The retrospective study included 116 patients with 116 suspicious breast lesions, which showed washout curve on DCE-MRI, who underwent subsequent biopsy. Morphologic characteristics on DCE-MRI and ADC values on DWI were evaluated. Apparent diffusion coefficient values and morphologic features of benign and malignant lesions were compared. Diagnostic values of DCE-MRI and combined MRI, including DCE-MRI and DWI (applying an ADC cutoff value) for distinguishing malignancy from benign lesions, were calculated. Results: Of the 116 breast lesions, 79 were malignant and 37 were benign. The ADC value of malignant tumors (median ADC, 0.72 x 10(-3) mm(2)/s) was significantly lower than that of benign lesions (median ADC, 1.03 x 10(-3) mm(2)/s; P < .000). The sensitivity and specificity of an ADC cutoff value of 0.89 x 10(-3) mm(2)/s were 92% and 95%, respectively. Dynamic contrast-enhanced MRI alone presented 100% sensitivity and 59.4% specificity. Adding an ADC cutoff value of 0.89 x 10(-3) mm(2)/s provided 100% sensitivity and 81% specificity, which would have prevented biopsy for 21.6% of benign lesions without missing any malignancies. Conclusion: Applying an ADC cutoff value to DCE-MRI provides an improvement in the diagnostic value of breast MRI for differentiating among lesions presenting washout curve.en_US
dc.identifier.endpage469en_US
dc.identifier.issn0846-5371en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85083056085en_US
dc.identifier.startpage460en_US
dc.identifier.urihttp://hdl.handle.net/11727/7459
dc.identifier.volume72en_US
dc.identifier.wos000678693300020en_US
dc.language.isoengen_US
dc.relation.isversionof10.1177/0846537120907098en_US
dc.relation.journalCANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbreast canceren_US
dc.subjectapparent diffusion coefficienten_US
dc.subjectwashout curveen_US
dc.subjectdynamic contrast-enhanced MRIen_US
dc.subjectdiffusion-weighted MRIen_US
dc.titleThe Role of Combined Diffusion-Weighted Imaging and Dynamic Contrast-Enhanced MRI for Differentiating Malignant From Benign Breast Lesions Presenting Washout Curveen_US
dc.typearticleen_US

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