Thrombin lag time is increased in children with mild asthma

dc.contributor.authorKoksal, B.T.
dc.contributor.authorEker, I.
dc.contributor.authorOzbek, N.Y.
dc.contributor.authorDogan, I.
dc.contributor.authorOzbek, O.Y.
dc.contributor.orcID0000-0001-9580-7656en_US
dc.contributor.pubmedID30262412en_US
dc.date.accessioned2020-12-28T13:45:34Z
dc.date.available2020-12-28T13:45:34Z
dc.date.issued2019
dc.description.abstractBackground: Inflammation and coagulation are closely linked events. Thrombin is the key enzyme in coagulation system and also has roles in inflammation. Objective: The aim of our study was to evaluate thrombin generation in children with mild asthma. Methods: Forty-two children with mild asthma and 49 healthy children were included in the study. All patients performed spirometry. Thrombin generation tests (TGT) were performed with a calibrated automated thrombogram (CAT) in children without asthma exacerbation during the last six months. During CAT assay thrombogram curves were obtained. The area under the curve showed endogenous thrombin potentials and indicated the total amount of endogenous thrombin generated; the peak height showed the highest thrombin value, thrombin lag time and time to thrombin peak were measured. Results: Thrombin lag time was significantly longer in children with asthma (3.98 1.2 min) compared to those in the control group (3.29 +/- 0.6 min) (p < 0.01). Children with asthma also had longer thrombin tail time compared to the control group (19.5 +/- 8.9 min vs. 16.7 +/- 2.9 min, p= 0.02). Thrombin peak was inversely correlated with FEF 25-75 (r =-0.41, p < 0.01). Thrombin lag time was inversely correlated with FEF 25-75 (r=-0.39, p<0.01). Conclusion: Inflammation in mild asthma seems to disturb coagulation but this disturbance may not be so strong as to increase thrombin levels and may only affect the initiation phase of thrombin generation. (C) 2018 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.identifier.endpage245en_US
dc.identifier.issn0301-0546en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85053822828en_US
dc.identifier.startpage241en_US
dc.identifier.urihttp://hdl.handle.net/11727/5290
dc.identifier.volume47en_US
dc.identifier.wos000466999000007en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.aller.2018.07.002en_US
dc.relation.journalALLERGOLOGIA ET IMMUNOPATHOLOGIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsthmaen_US
dc.subjectCalibrated automated thrombogram (CAT)en_US
dc.subjectChildrenen_US
dc.subjectCoagulationen_US
dc.subjectLung function testen_US
dc.subjectInflammationen_US
dc.subjectThrombinen_US
dc.subjectThrombin generation testen_US
dc.titleThrombin lag time is increased in children with mild asthmaen_US
dc.typearticleen_US

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: