Effects of topical Coenzyme Q10, Xanthan Gum and Sodium Hyaluronate on corneal epithelial wound healing

dc.contributor.authorAsena, Leyla
dc.contributor.authorGokgoz, Gulsah
dc.contributor.authorHelvacioglu, Fatma
dc.contributor.authorOzgun, Gonca
dc.contributor.authorDeniz, Emine Ebru
dc.contributor.authorAltinors, Dilek Dursun
dc.contributor.orcID0000-0002-6848-203Xen_US
dc.contributor.orcID0000-0002-4837-7937en_US
dc.contributor.orcID0000-0002-6026-0045en_US
dc.contributor.pubmedID34134604en_US
dc.contributor.researcherIDE-5914-2016en_US
dc.contributor.researcherIDAAY-7932-2021en_US
dc.contributor.researcherIDAAH-8887-2021en_US
dc.date.accessioned2022-09-07T11:22:39Z
dc.date.available2022-09-07T11:22:39Z
dc.date.issued2021
dc.description.abstractBackground: The aim was to compare the effects of three different eye drops on corneal epithelial wound healing in an experimental model. Methods: Twenty-four eyes of 24 female BALB/c mice were included. A 2 mm central corneal epithelial defect was created. Topical Coenzyme Q10 + Vitamin E D-alpha-TPGS 4 x 1 was applied to Group A (n = 6), topical Sodium hyaluronate + Xanthan Gum + 0.3% Nethylmicine 4 x 1 to Group B (n = 6) and topical Sodium hyaluronate 4 x 1 to Group C (n = 6). Group D (n = 6) was the control group without treatment. Clinical scoring according to corneal fluorescein staining and histopathological evaluations was performed. Results: Clinical scores according to corneal fluorescein staining were similar in all groups on days 1 (p = 0.05), 2 (p = 0.15) and 3 (p = 0.62). Electron microscopy revealed disruption of intercellular junctions between corneal epithelial cells and intracellular vacuole formation in all groups except Group A. Corneal epithelial thickness and superficial epithelial microvillus arrangement were close to normal in Group A. Conclusion: Although there was no difference in clinical scores between groups, electron microscopy revealed a better organised epithelium with normal configuration of microvilli and less vacuolisation in Group Aen_US
dc.identifier.endpage384en_US
dc.identifier.issn0816-4622en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85107954930en_US
dc.identifier.startpage378en_US
dc.identifier.urihttp://hdl.handle.net/11727/7561
dc.identifier.volume105en_US
dc.identifier.wos000662081000001en_US
dc.language.isoengen_US
dc.relation.isversionof10.1080/08164622.2021.1932433en_US
dc.relation.journalCLINICAL AND EXPERIMENTAL OPTOMETRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoenzyme Q10en_US
dc.subjectCornea epitheliumen_US
dc.subjectSodium hyaluronateen_US
dc.subjectWound healingen_US
dc.subjectXanthan gumen_US
dc.titleEffects of topical Coenzyme Q10, Xanthan Gum and Sodium Hyaluronate on corneal epithelial wound healingen_US
dc.typearticleen_US

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