sEPCR Levels in Chronic Myeloproliferative Diseases and Their Association with Thromboembolic Events: A Case-Control Study
dc.contributor.author | Atalay, Figen | |
dc.contributor.author | Toprak, Selami Kocak | |
dc.contributor.author | Koca, Ebru | |
dc.contributor.author | Karakus, Sena | |
dc.date.accessioned | 2019-12-21T13:59:47Z | |
dc.date.available | 2019-12-21T13:59:47Z | |
dc.date.issued | 2014 | |
dc.description.abstract | Objective: Venous, arterial, and microcirculatory events are frequently encountered in the clinical course of essential thrombocytosis and polycythemia vera. We aimed to investigate the levels of soluble endothelial protein C receptor (sEPCR) in myeloproliferative diseases to see whether there was a difference between the patients with and without history of thromboembolism. Materials and Methods: The study included patients with polycythemia vera (n=12), patients with essential thrombocytosis (n=13), and controls (n=29). In all groups, we measured proteins C and S, antithrombin and sEPCR levels, and plasma concentrations of thrombin-antithrombin complex, prothrombin fragments 1+2, and D-dimer. Results: Comparing the patients with and without history of thromboembolic attack, statistically significant differences were not observed in terms of sEPCR, D-dimer, thrombin-antithrombin complex, prothrombin fragments 1+2, and hematocrit levels (p=0.318, 0.722, 0.743, 0.324, and 0.065, respectively). Conclusion: Significant increase in the parameters that reflect activation of coagulation, such as sEPCR, thrombin-antithrombin complex, prothrombin fragments 1+2, and D-dimer, reflects the presence of a basal condition that leads to a tendency toward thrombosis development in ET and PV when compared to healthy controls. | en_US |
dc.identifier.endpage | 127 | en_US |
dc.identifier.issn | 1300-7777 | |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 121 | en_US |
dc.identifier.uri | https://www.journalagent.com/tjh/pdfs/TJH_31_2_121_127.pdf | |
dc.identifier.uri | http://hdl.handle.net/11727/4511 | |
dc.identifier.volume | 31 | en_US |
dc.identifier.wos | 000338094600002 | |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.4274/tjh.2012.0150 | en_US |
dc.relation.journal | TURKISH JOURNAL OF HEMATOLOGY | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Myeloproliferative disorders | en_US |
dc.subject | Endothelial cell protein C receptor | en_US |
dc.subject | Thrombosis | en_US |
dc.title | sEPCR Levels in Chronic Myeloproliferative Diseases and Their Association with Thromboembolic Events: A Case-Control Study | en_US |
dc.type | article | en_US |