sEPCR Levels in Chronic Myeloproliferative Diseases and Their Association with Thromboembolic Events: A Case-Control Study

dc.contributor.authorAtalay, Figen
dc.contributor.authorToprak, Selami Kocak
dc.contributor.authorKoca, Ebru
dc.contributor.authorKarakus, Sena
dc.date.accessioned2019-12-21T13:59:47Z
dc.date.available2019-12-21T13:59:47Z
dc.date.issued2014
dc.description.abstractObjective: Venous, arterial, and microcirculatory events are frequently encountered in the clinical course of essential thrombocytosis and polycythemia vera. We aimed to investigate the levels of soluble endothelial protein C receptor (sEPCR) in myeloproliferative diseases to see whether there was a difference between the patients with and without history of thromboembolism. Materials and Methods: The study included patients with polycythemia vera (n=12), patients with essential thrombocytosis (n=13), and controls (n=29). In all groups, we measured proteins C and S, antithrombin and sEPCR levels, and plasma concentrations of thrombin-antithrombin complex, prothrombin fragments 1+2, and D-dimer. Results: Comparing the patients with and without history of thromboembolic attack, statistically significant differences were not observed in terms of sEPCR, D-dimer, thrombin-antithrombin complex, prothrombin fragments 1+2, and hematocrit levels (p=0.318, 0.722, 0.743, 0.324, and 0.065, respectively). Conclusion: Significant increase in the parameters that reflect activation of coagulation, such as sEPCR, thrombin-antithrombin complex, prothrombin fragments 1+2, and D-dimer, reflects the presence of a basal condition that leads to a tendency toward thrombosis development in ET and PV when compared to healthy controls.en_US
dc.identifier.endpage127en_US
dc.identifier.issn1300-7777
dc.identifier.issue2en_US
dc.identifier.startpage121en_US
dc.identifier.urihttps://www.journalagent.com/tjh/pdfs/TJH_31_2_121_127.pdf
dc.identifier.urihttp://hdl.handle.net/11727/4511
dc.identifier.volume31en_US
dc.identifier.wos000338094600002
dc.language.isoengen_US
dc.relation.isversionof10.4274/tjh.2012.0150en_US
dc.relation.journalTURKISH JOURNAL OF HEMATOLOGYen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMyeloproliferative disordersen_US
dc.subjectEndothelial cell protein C receptoren_US
dc.subjectThrombosisen_US
dc.titlesEPCR Levels in Chronic Myeloproliferative Diseases and Their Association with Thromboembolic Events: A Case-Control Studyen_US
dc.typearticleen_US

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