Fecal calprotectin levels in Helicobacter pylori gastritis in children

dc.contributor.authorAksoy, Ozlem Yuksel
dc.contributor.authorCanan, Oguz
dc.contributor.authorHosnut, Ferda Ozbay
dc.contributor.authorAkcay, EdaYilmaz
dc.contributor.authorOzcay, Figen
dc.contributor.orcID0000-0003-0614-4497en_US
dc.contributor.orcID0000-0002-5214-516Xen_US
dc.contributor.pubmedID33372437en_US
dc.contributor.researcherIDAAI-9386-2021en_US
dc.contributor.researcherIDABG-5684-2020en_US
dc.date.accessioned2021-03-30T08:28:14Z
dc.date.available2021-03-30T08:28:14Z
dc.date.issued2020
dc.description.abstractBackground. Fecal calprotectin is an important inflammatory marker in intestinal diseases and is not routinely used in the upper gastrointestinal system disorders. The aim of this study was to show whether there is a relationship between fecal calprotectin levels and Helicobacter pylori (H pylori) gastritis in children and to determine the association of fecal calprotectin levels with gastric biopsy results in terms of chronic inflammation and neutrophil activity. Methods. Patients with the complaints of the upper gastrointestinal system (epigastric pain, heartburn, nausea and vomiting) who were planned to undergo endoscopy were enrolled prospectively. The presence of H pylori was defined according to the gastric antrum biopsy results. Fecal calprotectin level was tested in the stool sample of the patients. The fecal calprotectin levels, upper gastrointestinal endoscopy and gastric biopsy results of 89 patients were evaluated. Results. H pylori was found to be positive in the gastric biopsies of 51 (57.3%) patients. In the H pylori positive group mean fecal calprotectin level was 74.8 +/- 67 mu g/g, and in the H pylori negative group mean fecal calprotectin level was 52.7 +/- 46 mu g/g and the difference was significant (p= 0.039). We also found a significant relationship between fecal calprotectin levels and gastric neutrophil activity grades (p= 0.034). Conclusions. Mean fecal calprotectin levels were found to be higher in H pylori positive subjects in our study. Fecal calprotectin levels were correlated with gastric neutrophil activity grades. Fecal calprotectin represents gastric neutrophilic inflammation. When interpreting a high fecal calprotectin level, H pylori infection should be kept in mind.en_US
dc.identifier.endpage993en_US
dc.identifier.issn0041-4301en_US
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85097781306en_US
dc.identifier.startpage986en_US
dc.identifier.urihttp://www.turkishjournalpediatrics.org/uploads/pdf_TJP_2238.pdf
dc.identifier.urihttp://hdl.handle.net/11727/5629
dc.identifier.volume62en_US
dc.identifier.wos000598886500010en_US
dc.language.isoengen_US
dc.relation.isversionof10.24953/turkjped.2020.06.010en_US
dc.relation.journalTURKISH JOURNAL OF PEDIATRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectfecal calprotectinen_US
dc.subjectgastritisen_US
dc.subjectgastric biopsyen_US
dc.subjectHelicobacter pylorien_US
dc.subjectchilden_US
dc.subjectpediatricen_US
dc.titleFecal calprotectin levels in Helicobacter pylori gastritis in childrenen_US
dc.typearticleen_US

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