Comparison between body composition parameters and response to neoadjuvant chemotherapy by using pre-treatment PET CT in locally advanced breast cancer
dc.contributor.author | Yirgin, İnci Kizildag | |
dc.contributor.author | Has, Duygu | |
dc.contributor.author | Arslan, Gozde | |
dc.contributor.author | Aydin, Esra Cureoglu | |
dc.contributor.author | Sari, Murat | |
dc.contributor.author | Onder, Semen | |
dc.contributor.author | Yasemin, Sanli | |
dc.contributor.author | Cabioglu, Neslihan | |
dc.contributor.author | Karanlik, Hasan | |
dc.contributor.author | Tukenmez, Mustafa | |
dc.contributor.author | Dursun, Memduh | |
dc.contributor.author | Muslumanoglu, Mahmut | |
dc.contributor.author | Ozmen, Vahit | |
dc.contributor.pubmedID | 33294497 | en_US |
dc.date.accessioned | 2021-03-30T08:42:16Z | |
dc.date.available | 2021-03-30T08:42:16Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Purpose: To compare the adipose and muscle tissue areas in patients who responded differently to neoadjuvant chemotherapy. Methods: One hundred and eighty six patients diagnosed with breast cancer who underwent neoadjuvant chemotherapy between January 2015- October 2019 and were operated after the treatment were retrospectively included in the study. Pathological results were divided into five groups using the Miller-Payne grading systems. Grade 1 indicating no significant reduction in malignant cells; Grade 2: a minor loss of malignant cells (<= 30 %); Grade 3: reduction in malignant cells between 30 % and 90 %; Grade 4: disappearance of malignant cells >90 %; Grade 5: no malignant cells identifiable. Pre-treatment PET CT scans were evaluated, and calculation of body composition parameters were performed on a single axial section passing through the L3 vertebrae. Spearman's correlation test was used to analyze the correlation between SAT, VAT, MT parameters and pathological responses. Results: There was no strong correlation between the 5 groups separated according to neoadjuvant chemotherapy treatment response and tissue distributions. However, that there was a very low correlation found between superficial adipose tissue and pathological response (r=, 156). Conclusion: In conclusion, our results have provided a very low correlation between SAT and more than 30 % response. More research is required to evaluate the role of the body fat and muscle parameters in response to neoadjuvant chemotherapy in larger patient populations. | en_US |
dc.identifier.eissn | 2352-0477 | en_US |
dc.identifier.scopus | 2-s2.0-85097149321 | en_US |
dc.identifier.uri | https://www.ejropen.com/article/S2352-0477(20)30075-7/pdf | |
dc.identifier.uri | http://hdl.handle.net/11727/5633 | |
dc.identifier.volume | 7 | en_US |
dc.identifier.wos | 000600597400075 | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.1016/j.ejro.2020.100286 | en_US |
dc.relation.journal | EUROPEAN JOURNAL OF RADIOLOGY OPEN | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Adipose tissue | en_US |
dc.subject | Body composition parameter | en_US |
dc.subject | Breast cancer | en_US |
dc.subject | Computed tomography | en_US |
dc.title | Comparison between body composition parameters and response to neoadjuvant chemotherapy by using pre-treatment PET CT in locally advanced breast cancer | en_US |
dc.type | article | en_US |
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