Comparison between body composition parameters and response to neoadjuvant chemotherapy by using pre-treatment PET CT in locally advanced breast cancer

dc.contributor.authorYirgin, İnci Kizildag
dc.contributor.authorHas, Duygu
dc.contributor.authorArslan, Gozde
dc.contributor.authorAydin, Esra Cureoglu
dc.contributor.authorSari, Murat
dc.contributor.authorOnder, Semen
dc.contributor.authorYasemin, Sanli
dc.contributor.authorCabioglu, Neslihan
dc.contributor.authorKaranlik, Hasan
dc.contributor.authorTukenmez, Mustafa
dc.contributor.authorDursun, Memduh
dc.contributor.authorMuslumanoglu, Mahmut
dc.contributor.authorOzmen, Vahit
dc.contributor.pubmedID33294497en_US
dc.date.accessioned2021-03-30T08:42:16Z
dc.date.available2021-03-30T08:42:16Z
dc.date.issued2020
dc.description.abstractPurpose: To compare the adipose and muscle tissue areas in patients who responded differently to neoadjuvant chemotherapy. Methods: One hundred and eighty six patients diagnosed with breast cancer who underwent neoadjuvant chemotherapy between January 2015- October 2019 and were operated after the treatment were retrospectively included in the study. Pathological results were divided into five groups using the Miller-Payne grading systems. Grade 1 indicating no significant reduction in malignant cells; Grade 2: a minor loss of malignant cells (<= 30 %); Grade 3: reduction in malignant cells between 30 % and 90 %; Grade 4: disappearance of malignant cells >90 %; Grade 5: no malignant cells identifiable. Pre-treatment PET CT scans were evaluated, and calculation of body composition parameters were performed on a single axial section passing through the L3 vertebrae. Spearman's correlation test was used to analyze the correlation between SAT, VAT, MT parameters and pathological responses. Results: There was no strong correlation between the 5 groups separated according to neoadjuvant chemotherapy treatment response and tissue distributions. However, that there was a very low correlation found between superficial adipose tissue and pathological response (r=, 156). Conclusion: In conclusion, our results have provided a very low correlation between SAT and more than 30 % response. More research is required to evaluate the role of the body fat and muscle parameters in response to neoadjuvant chemotherapy in larger patient populations.en_US
dc.identifier.eissn2352-0477en_US
dc.identifier.scopus2-s2.0-85097149321en_US
dc.identifier.urihttps://www.ejropen.com/article/S2352-0477(20)30075-7/pdf
dc.identifier.urihttp://hdl.handle.net/11727/5633
dc.identifier.volume7en_US
dc.identifier.wos000600597400075en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.ejro.2020.100286en_US
dc.relation.journalEUROPEAN JOURNAL OF RADIOLOGY OPENen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdipose tissueen_US
dc.subjectBody composition parameteren_US
dc.subjectBreast canceren_US
dc.subjectComputed tomographyen_US
dc.titleComparison between body composition parameters and response to neoadjuvant chemotherapy by using pre-treatment PET CT in locally advanced breast canceren_US
dc.typearticleen_US

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