Daptomycin Versus Teicoplanin in the Treatment of Osteomyelitis: Results of the Goztepe Retrospective Cohort Study

dc.contributor.authorSipahi, O. R.
dc.contributor.authorErdem, H. A.
dc.contributor.authorKahraman, H.
dc.contributor.authorKursun, E.
dc.contributor.authorSuntur, B. M.
dc.contributor.authorDemirdal, T.
dc.contributor.authorNemli, S. A.
dc.contributor.authorDizbay, M.
dc.contributor.authorUlug, M.
dc.contributor.authorOztoprak-Cuvalci, N.
dc.contributor.authorArda, B.
dc.contributor.authorQuliyeva, G.
dc.contributor.authorTasbakan, M.
dc.contributor.authorUysal, S.
dc.contributor.authorSipahi, H.
dc.contributor.authorAydemir, S.
dc.contributor.authorUlusoy, S.
dc.contributor.pubmedID33870888en_US
dc.date.accessioned2022-09-07T12:58:38Z
dc.date.available2022-09-07T12:58:38Z
dc.date.issued2021
dc.description.abstractObjectives: Daptomycin is highly effective against Gram-positive multidrug-resistant bacteria. Publications on daptomycin in osteomyelitis treatment are limited. Patients and methods: In this multicenter retrospective cohort study, the aim was to evaluate the outcomes of osteomyelitis cases having received daptomycin or teicoplanin. This multicenter retrospective cohort study gathered data from seven centers located in five cities of Turkey. Study inclusion criteria were as follows: (a) magnetic resonance imaging and/or direct X-ray revealed osteomyelitis or biopsy pathologic examination results concomitant with osteomyelitis. Chi-squareand Student t-tests were used for statistical comparison. Results: A total of 72 patients, 38 cases in the daptomycin group and 34 cases in the teicoplanin group diagnosed with osteomyelitis fulfilling the study inclusion criteria, were included in the study. Clinical success at the end of induction therapy was achieved in 32/38 cases in the daptomycin cohort vs. 30/34 cases in the teicoplanin cohort (p: 0.73). Conclusion: Although this is a limited experience in a small but well-defined cohort, our data suggest that daptomycin may be a safe alternative to glycopeptides in osteomyelitis treatment. A randomized controlled clinical study involving larger cohorts may increase the available evidence.en_US
dc.identifier.endpage367en_US
dc.identifier.issn2666-9927en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85105328990en_US
dc.identifier.startpage362en_US
dc.identifier.urihttps://reader.elsevier.com/reader/sd/pii/S2666991921000294?token=F69B4C3799E3D8DD957C7E83B119A50C12D6F0FA176B25403F6416F55AEC45FF7C2D6F8ACC65C65F14B334D9D0D8AC85&originRegion=eu-west-1&originCreation=20220907125627
dc.identifier.urihttp://hdl.handle.net/11727/7582
dc.identifier.volume51en_US
dc.identifier.wos000651874700007en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.idnow.2021.01.009en_US
dc.relation.journalInfectious Dıseases Nowen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRESISTANT STAPHYLOCOCCUS-AUREUSen_US
dc.subjectOSTEOARTICULAR INFECTIONSen_US
dc.subjectVANCOMYCINen_US
dc.subjectBONEen_US
dc.subjectPENETRATIONen_US
dc.subjectEFFICACYen_US
dc.subjectTHERAPYen_US
dc.subjectSAFETYen_US
dc.titleDaptomycin Versus Teicoplanin in the Treatment of Osteomyelitis: Results of the Goztepe Retrospective Cohort Studyen_US
dc.typearticleen_US

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