Clinical Outcomes of Liver Transplantation for Patients Over 60 Years Old: a Single-Center Experience

Abstract

Objectives: Although advanced age is no longer considered an absolute contraindication for liver transplant, transplant in elderly patients with comorbid diseases remains debatable because of high risks with surgery. Here, we report patient outcomes in this population.

Materials and Methods: We retrospectively reviewed medical records of 276 liver transplant recipients, grouped by age. Group 1 (=59 years old) consisted of 247 recipients, and group 2 (=60 years old) consisted of 29 recipients. Reviewed data included age, sex, cause of liver disease, presence of hepatocellular carcinoma, Child-Pugh and Model for End-Stage Liver Disease scores, survival, and posttransplant complications.

Results: In both groups,mostpatients (n = 108) required liver transplant for hepatitis B virus. Mean age was 40 +/- 12.3 and 63 +/- 2.3 years in groups 1 and 2, respectively, with more men than women in both group 1 (71.7% vs 28.3%) and group 2 (75.9% vs 24.1%). No significant differences were shown between groups for patient characteristics, except group 1 had significantly higher Model for End-Stage Liver Disease score. Group 1 mean survival time was 10.2 +/- 0.6 years, with patient survival rates at 1, 5, 10, and 15 years of 65.5%, 53%, 46.3%, and 40%, respectively. In group 2, respective results were 10.6 +/- 1.3 years and 75.9%, 68.6%, 61%, and 48.8% (no significant difference vs group 1).

Conclusions: Liver transplant recipients >60 years of age had survival rates, acute rejection rates, and complications similar to younger recipients. Liver transplant should not be withheldfromolderrecipients on the basis of age alone. However, comprehensive screening for comorbidities should be performed.