Association between focal adhesion kinase and matrix metalloproteinase-9 expression in prostate adenocarcinoma and their influence on the progression of prostatic adenocarcinoma

dc.contributor.authorAtilgan, Alev Ok
dc.contributor.authorOzdemir, B. Handan
dc.contributor.authorAkcay, Eda Yilmaz
dc.contributor.authorTepeoglu, Merih
dc.contributor.authorBorcek, Pelin
dc.contributor.authorDirim, Ayhan
dc.contributor.orcID0000-0002-7528-3557en_US
dc.contributor.orcID0000-0001-8595-8880en_US
dc.contributor.orcID0000-0002-9894-8005en_US
dc.contributor.orcID0000-0001-6831-9585en_US
dc.contributor.orcID0000-0003-2898-485Xen_US
dc.contributor.pubmedID32106037en_US
dc.contributor.researcherIDX-8540-2019en_US
dc.contributor.researcherIDAAK-3333-2021en_US
dc.contributor.researcherIDAAK-5222-2021en_US
dc.contributor.researcherIDAAK-1960-2021en_US
dc.contributor.researcherIDAAJ-5689-2021en_US
dc.date.accessioned2021-06-21T06:38:18Z
dc.date.available2021-06-21T06:38:18Z
dc.date.issued2020
dc.description.abstractFocal adhesion kinase (FAK), a member of the non-receptor cytoplasmic tyrosine kinase family, is associated with the development and progression of cancer. Matrix metalloproteinase-9 (MMP-9) is directly involved in the degradation of the extracellular matrix, and basement membrane components promote cancer cell migration and invasion. There is a functional interaction among FAK, MMP-9 and vascular endothelial growth factor (VEGF), which leads to enhanced cancer angiogenesis, cancer cell invasion and progression of malignancy. FAK, MMP-9, VEGF and CD34-positive microvessel density (MVD) were examined in 100 patients with prostate adenocarcinoma using immunohistochemistry. The relationship among these proteins and their impact on angiogenesis and clinicopathological parameters were also evaluated. The FAK expression was found to be positively correlated with the Gleason score, WHO grade group, tumour stage, extracapsular extension and perineural invasion. The MMP-9 expression was positively correlated with the WHO grade group, tumour stage, extracapsular extension, positive surgical margin and lymphovascular and perineural invasion. The FAK expression was also positively correlated with MMP-9 expression and MVD. However, no correlation between FAK and VEGF expression was identified. The MMP-9 expression was positively correlated with FAK expression and MVD. Strong MMP-9 expression was associated with shorter disease-free survival. These results suggest that strong MMP-9 and FAK expressions play an essential role in the progression of prostate adenocarcinoma. Further investigations should be conducted to determine the importance of these proteins as therapeutic targets for patients with prostate adenocarcinomas.en_US
dc.identifier.issn1092-9134en_US
dc.identifier.scopus2-s2.0-85079669580en_US
dc.identifier.urihttp://hdl.handle.net/11727/6116
dc.identifier.volume45en_US
dc.identifier.wos000527850100018en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.anndiagpath.2020.151480en_US
dc.relation.journalANNALS OF DIAGNOSTIC PATHOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFocal Adhesion Kinaseen_US
dc.subjectMatrix Metalloproteinase-9en_US
dc.subjectMicrovessel Densityen_US
dc.subjectProstateen_US
dc.titleAssociation between focal adhesion kinase and matrix metalloproteinase-9 expression in prostate adenocarcinoma and their influence on the progression of prostatic adenocarcinomaen_US
dc.typearticleen_US

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