Predictive values of maternal serum PAPP-A level, uterine artery Doppler velocimetry, and fetal biometric measurements for poor pregnancy and poor neonatal outcomes in pregnant women
dc.contributor.author | Balci, Serdar | |
dc.contributor.orcID | 0000-0002-1782-7325 | en_US |
dc.contributor.pubmedID | 27651722 | en_US |
dc.contributor.researcherID | AAJ-1097-2021 | en_US |
dc.date.accessioned | 2019-06-20T08:27:23Z | |
dc.date.available | 2019-06-20T08:27:23Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Objective: To determine predictive values of maternal serum PAPP-A (msPAPP-A) levels, uterine artery Doppler velocimetry, and fetal biometric measurements (FBMs) for poor pregnancy and poor neonatal outcomes. Material and Methods: This prospective cohort study was conducted on singleton pregnancies followed until delivery. Pregnancy and neonatal outcomes were evaluated with respect to the msPAPP-A level at the 11th-14th weeks, uterine artery Doppler velocimetry at the 15th-18th weeks, and FBMs at the 20th-24th and 28th-32nd weeks of pregnancy. Results: One hundred fifty-eight women constituted the study group; 17 (10.75%) of them had at least one poor pregnancy outcome. The cut-off point of 0.72 multiple of the median (MoM) for the PAPP-A level achieved a sensitivity of 82.4% and a specificity of 29.8% for poor pregnancy outcomes. The mean birth weight was significantly lower in the subgroup with a higher mean pulsatility index of uterine arteries (UAPImean >= 1.19) (p=0.025) as well as in the subgroup with a higher mean resistance index of uterine arteries (UARImean >= 0.62) (p=0.013). When the subgroup of pregnant women under the risk of early-onset IUGR according to FBMs was compared to the low-risk group, statistically significant differences were seen in terms of pregnancy outcomes (p=0.045) and birth weight (p=0.011). Conclusion: Maternal serum PAPP-A level and FBMs could be used for predicting pregnancy outcomes, while uterine artery Doppler velocimetry and FBMs could be used for predicting neonatal outcomes, specifically the birth weight. | en_US |
dc.identifier.endpage | 149 | en_US |
dc.identifier.issn | 1309-0399 | |
dc.identifier.issue | 3 | en_US |
dc.identifier.scopus | 2-s2.0-84987615830 | en_US |
dc.identifier.startpage | 143 | en_US |
dc.identifier.uri | http://cms.galenos.com.tr/Uploads/Article_13505/143-149.pdf | |
dc.identifier.uri | http://hdl.handle.net/11727/3617 | |
dc.identifier.volume | 17 | en_US |
dc.identifier.wos | 000391064900007 | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.5152/jtgga.2016.16040 | en_US |
dc.relation.journal | JOURNAL OF THE TURKISH-GERMAN GYNECOLOGICAL ASSOCIATION | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Pregnancy-associated plasma protein-a | en_US |
dc.subject | Ultrasonography | en_US |
dc.subject | Doppler | en_US |
dc.subject | Color | en_US |
dc.subject | Fetal biometry | en_US |
dc.subject | Pregnancy outcome | en_US |
dc.subject | Fetal development | en_US |
dc.title | Predictive values of maternal serum PAPP-A level, uterine artery Doppler velocimetry, and fetal biometric measurements for poor pregnancy and poor neonatal outcomes in pregnant women | en_US |
dc.type | article | en_US |