Benzamide and Benzamidine Compounds as New Inhibitors of Urokinase-type Plasminogen Activators

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dc.contributor.authorKus, Canan
dc.contributor.authorOzer, Ezgi
dc.contributor.authorKorkmaz, Yesim
dc.contributor.authorYurtcu, Erkan
dc.contributor.authorDagalp, Rukiye
dc.contributor.orcID0000-0001-6141-6788en_US
dc.contributor.orcID0000-0003-4930-8164en_US
dc.contributor.orcID0000-0002-7335-8578en_US
dc.contributor.pubmedID30112993en_US
dc.contributor.researcherIDAAG-1459-2020en_US
dc.contributor.researcherIDAAA-2998-2021en_US
dc.contributor.researcherIDW-1812-2017en_US
dc.date.accessioned2023-05-11T13:25:04Z
dc.date.available2023-05-11T13:25:04Z
dc.date.issued2018
dc.description.abstractBackground & Method: In this ongoing research, it is aimed to investigate the synthesis, structure identification and effects on urokinase-type plasminogen activators (uPA) and its receptor levels of 4-(3H-imidazo[4,5-b] pyridin-2-yl)-N-substituted benzamide and benzamidine derivatives. uPA levels obtained from 4b and 7d administration were similar to 5-FU (5-fluorouracil) for colorectal carcinoma cells (p<0.05). 4b and 7d significantly reduced uPAR (urokinase-type plasminogen activator receptor) levels on both cell lines (p<0.05). Conclusion: uPAR levels obtaining from 4b and 7d administration were similar to 5-FU for both cell lines colorectal (Colo205, CCL-222) and hepatocellular (HepG2, CCL-23) carcinoma cells (p<0.05).en_US
dc.identifier.endpage1758en_US
dc.identifier.issn1389-5575en_US
dc.identifier.issue20en_US
dc.identifier.scopus2-s2.0-85057451499en_US
dc.identifier.startpage1753en_US
dc.identifier.urihttp://hdl.handle.net/11727/9005
dc.identifier.volume18en_US
dc.identifier.wos000451817800005en_US
dc.language.isoengen_US
dc.relation.isversionof10.2174/1389557518666180816110740en_US
dc.relation.journalMINI-REVIEWS IN MEDICINAL CHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImidazopyridineen_US
dc.subjectbenzamideen_US
dc.subjectbenzamidineen_US
dc.subjecturinary plasminogen activatoren_US
dc.subjectuPARen_US
dc.subjectupamostaten_US
dc.titleBenzamide and Benzamidine Compounds as New Inhibitors of Urokinase-type Plasminogen Activatorsen_US
dc.typearticleen_US

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