Immunogenicity after two doses of inactivated virus vaccine in healthcare workers with and without previous COVID-19 infection: Prospective observational study

dc.contributor.authorYalcin, Tugba Y.
dc.contributor.authorTopcu, Deniz, I
dc.contributor.authorSari, Nuran
dc.contributor.authorErol, Cigdem
dc.contributor.authorAzap, Ozlem K.
dc.contributor.authorArslan, Hande
dc.contributor.orcID0000-0002-3165-4520en_US
dc.contributor.orcID0000-0001-5996-8639en_US
dc.contributor.orcID0000-0002-2535-2534en_US
dc.contributor.orcID0000-0002-5708-7915en_US
dc.contributor.orcID0000-0002-3171-8926en_US
dc.contributor.pubmedID34468990en_US
dc.contributor.researcherIDABA-1149-2021en_US
dc.contributor.researcherIDAAA-4708-2022en_US
dc.contributor.researcherIDAAJ-1219-2021en_US
dc.contributor.researcherIDABG-7034-2021en_US
dc.contributor.researcherIDAAK-4089-2021en_US
dc.date.accessioned2022-08-16T09:43:20Z
dc.date.available2022-08-16T09:43:20Z
dc.date.issued2021
dc.description.abstractVaccines have been seen as the most important solution for ending the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study is to evaluate the antibody levels after inactivated virus vaccination. We included 148 healthcare workers (74 with prior COVID-19 infection and 74 with not). They received two doses of inactivated virus vaccine (CoronaVac). Serum samples were prospectively collected three times (Days 0, 28, 56). We measured SARS-CoV-2 IgGsp antibodies quantitatively and neutralizing antibodies. After the first dose, antibody responses did not develop in 64.8% of the participants without prior COVID-19 infection. All participants had developed antibody responses after the second dose. We observed that IgGsp antibody titers elicited by a single vaccine dose in participants with prior COVID-19 infection were higher than after two doses of vaccine in participants without prior infection (geometric mean titer: 898 and 607 AU/ml). IgGsp antibodies, participants with prior COVID-19 infection had higher antibody levels as geometric mean titers at all time points (p < 0.001). We also found a positive correlation between IgGsp antibody titers and neutralizing capacity (r(s) = 0.697, p < 0.001). Although people without prior COVID-19 infection should complete their vaccination protocol, the adequacy of a single dose of vaccine is still in question for individuals with prior COVID-19. New methods are needed to measure the duration of protection of vaccines and their effectiveness against variants as the world is vaccinated. We believe quantitative IgGsp values may reflect the neutralization capacity of some vaccines.en_US
dc.identifier.endpage286en_US
dc.identifier.issn0146-6615en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85114597984en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.27316
dc.identifier.urihttp://hdl.handle.net/11727/7356
dc.identifier.volume94en_US
dc.identifier.wos000694996400001en_US
dc.language.isoengen_US
dc.relation.isversionof10.1002/jmv.27316en_US
dc.relation.journalJOURNAL OF MEDICAL VIROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcoronaVacen_US
dc.subjectimmunogenicityen_US
dc.subjectinactivated virus vaccineen_US
dc.subjectneutralizing antibodyen_US
dc.subjectSARS-CoV-2 antibodyen_US
dc.titleImmunogenicity after two doses of inactivated virus vaccine in healthcare workers with and without previous COVID-19 infection: Prospective observational studyen_US
dc.typearticleen_US

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