The Effect of Sumatriptan in lschemic Conditions in the Rat Heart
| dc.contributor.author | Altunkaynak Camca, Hande Ozge | |
| dc.contributor.author | Tecder Unal, Muge | |
| dc.contributor.author | Tuncer, Meral | |
| dc.contributor.pubmedID | 32454677 | |
| dc.date.accessioned | 2019-04-26T08:48:19Z | |
| dc.date.available | 2019-04-26T08:48:19Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Objectives: The aim of this study was to investigate the effect of SUM on IR-induced injury in rat heart and its effect on IPC-induced protection. Materials and Methods: The rats were randomly divided into four groups: IR, SUM-IR, IPC, and SUM-IPC. The mean arterial blood pressure and heart rate were recorded to calculate PRP. Standard limb lead 2 ECG were recorded to evaluate arrhythmia parameters. Results: The PRP values in the SUM-IPC group were significantly lower than in the SUM-IR group at the beginning of reperfusion (p<0.05). The incidence of VT in the IPC, SUM-IR, and SUM-IPC groups was significantly lower than in the IR group (p<0.05). VF was only observed in the IR group. Conclusion: SUM protects the heart against IR injury but is not as protective as IPC alone. Although SUM diminishes IPC-induced protection against VT, the preventive effect of SUM against VF may be predictive for cardioprotection in ischemic conditions. | en_US |
| dc.identifier.endpage | 332 | en_US |
| dc.identifier.issn | 1304-530X | |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.startpage | 328 | en_US |
| dc.identifier.uri | http://cms.galenos.com.tr/Uploads/Article_18203/TJPS-15-328-En.pdf | |
| dc.identifier.uri | http://hdl.handle.net/11727/3097 | |
| dc.identifier.volume | 15 | en_US |
| dc.identifier.wos | 000450780900013 | en_US |
| dc.language.iso | eng | en_US |
| dc.relation.isversionof | 10.4274/tjps.03371 | en_US |
| dc.relation.journal | TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Sumatriptan | en_US |
| dc.subject | Heart | en_US |
| dc.subject | İschemia and reperfusion | en_US |
| dc.subject | ischemic preconditioning | en_US |
| dc.subject | Arrhythmia | en_US |
| dc.title | The Effect of Sumatriptan in lschemic Conditions in the Rat Heart | en_US |
| dc.type | article | en_US |