Association Between Mitral Valve Prolapse, Migraine, and White Matter Hyperintensities on Magnetic Resonance Imaging

dc.contributor.authorAvci, Aynur Yilmaz
dc.contributor.authorToprak, Munire Kilinc
dc.contributor.authorLakadamyali, Liatioe
dc.contributor.authorAkinci, Sinan
dc.date.accessioned2019-04-26T06:52:44Z
dc.date.available2019-04-26T06:52:44Z
dc.date.issued2018
dc.description.abstractObjective: Migraine is linked with an elevation in vascular risk factors, ischemic stroke, and a variety of constitutional brain lesions. However, the pathogenesis of this relationship is still inexplicit. The link between cardiac diseases and comorbid migraine-ischemic stroke might be a vascular disease involving both heart and brain. In this study, an association between mitral valve prolapse (MVP), migraine, and the presence of brain white matter hyperintensities (WMHs) were evaluated among adult subjects with migraine headache devoid of any traditional vascular risk factors. Materials and Methods: Four hundred subjects (200 subjects with migraine headache, 200 healthy controls; age range 18-50 years) were incorporated in the retrospective study. Existence of a headache compatible with migraine was diagnosed according to the International Headache Society-2 criteria. The participants were devoid of any known comorbid diseases, vascular risk factors or inflammatory diseases. All patients, both those with migraine and controls were screened with echocardiography to assess for MVP and with brain magnetic resonance imaging co evaluate the presence of any WMHs. Results: The prevalence of MVP was found to be higher in the migraine group (p<0.011). The odds ratio (OR) for the presence of MVP in patients with migraine compared with controls was 2.44 [95% confidence interval (CI): 1.25-4.74; p=0.0086]. The OR for the presence of WMHs in patients with migraine compared with controls was 5.88 (95% CI: 3.42-10.10; p<0.0001). After modifying for confounding factors, multiple linear regression analyses revealed that migraine was independently and positively associated with MVP (p=0.044), tricuspid regurgitation (p=0.003), and WMHs (p<0.001), and mitral regurgitation and migraine was independently and positively connected with WMHs (p<0.005 and p<0.001, respectively). Conclusion: MVP is found CO be independently associated with migraine when compared with controls. Therefore, we suggest that MVP might have an association with migraine. Nevertheless, we could not demonstrate any correlation between MVP and WMHs. Hence, we suggest that MVP might nor be involved in the evolution of WMHs in migraineen_US
dc.identifier.endpage329en_US
dc.identifier.issn1301-062X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85064936106en_US
dc.identifier.startpage323en_US
dc.identifier.urihttps://www.journalagent.com/tjn/pdfs/TJN_24_4_323_329%5BA%5D.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3088
dc.identifier.volume24en_US
dc.identifier.wos000452643700005en_US
dc.language.isoengen_US
dc.relation.isversionof10.4274/tnd.04468en_US
dc.relation.journalTURKISH JOURNAL OF NEUROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHeadacheen_US
dc.subjectVascular risken_US
dc.subjectCardiovascular risken_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectEchocardiographyen_US
dc.titleAssociation Between Mitral Valve Prolapse, Migraine, and White Matter Hyperintensities on Magnetic Resonance Imagingen_US
dc.typearticleen_US

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