Characteristics And Outcomes Of Carbapenemase Harbouring Carbapenem-Resistant Klebsiella Spp. Bloodstream Infections: A Multicentre Prospective Cohort Study In An OXA-48 Endemic Setting

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dc.contributor.authorIsler, Burcu
dc.contributor.authorOzer, Berna
dc.contributor.authorCinar, Gule
dc.contributor.authorAslan, Abdullah Tarik
dc.contributor.authorVatansever, Cansel
dc.contributor.authorFalconer, Caitlin
dc.contributor.authorDolapci, Istar
dc.contributor.authorSimsek, Funda
dc.contributor.authorTulek, Necla
dc.contributor.authorDemirkaya, Hamiyet
dc.contributor.authorMenekse, Sirin
dc.contributor.authorAkalin, Halis
dc.contributor.authorBalkan, Ilker Inanc
dc.contributor.authorAydin, Mehtap
dc.contributor.authorTigen, Elif Tukenmez
dc.contributor.authorDemir, Safiye Koculu
dc.contributor.authorKapmaz, Mahir
dc.contributor.authorKeske, Siran
dc.contributor.authorDogan, Ozlem
dc.contributor.authorArabaci, Cigdem
dc.contributor.authorYagci, Serap
dc.contributor.authorHazirolan, Gulsen
dc.contributor.authorBakir, Veli Oguzalp
dc.contributor.authorGonen, Mehmet
dc.contributor.authorChatfield, Mark D.
dc.contributor.authorForde, Brian
dc.contributor.authorSaltoglu, Nese
dc.contributor.authorAzap, Alpay
dc.contributor.authorAzap, Ozlem
dc.contributor.authorAkova, Murat
dc.contributor.authorPaterson, David L.
dc.contributor.authorCan, Fusun
dc.contributor.authorErgonul, Onder
dc.contributor.pubmedID35301623en_US
dc.date.accessioned2022-11-23T10:57:20Z
dc.date.available2022-11-23T10:57:20Z
dc.date.issued2022
dc.description.abstractA prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.en_US
dc.identifier.endpage847en_US
dc.identifier.issn0934-9723en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85126797654en_US
dc.identifier.startpage841en_US
dc.identifier.urihttp://hdl.handle.net/11727/8153
dc.identifier.volume41en_US
dc.identifier.wos000770200000001en_US
dc.language.isoengen_US
dc.relation.isversionof10.1007/s10096-022-04425-4en_US
dc.relation.journalEUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOXA-48en_US
dc.subjectOXA-232en_US
dc.subjectST2096en_US
dc.subjectKlebsiella pneumoniaeen_US
dc.subjectCeftazidime-avibactamen_US
dc.titleCharacteristics And Outcomes Of Carbapenemase Harbouring Carbapenem-Resistant Klebsiella Spp. Bloodstream Infections: A Multicentre Prospective Cohort Study In An OXA-48 Endemic Settingen_US
dc.typearticleen_US

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