Characteristics And Outcomes Of Carbapenemase Harbouring Carbapenem-Resistant Klebsiella Spp. Bloodstream Infections: A Multicentre Prospective Cohort Study In An OXA-48 Endemic Setting
dc.contributor.author | Isler, Burcu | |
dc.contributor.author | Ozer, Berna | |
dc.contributor.author | Cinar, Gule | |
dc.contributor.author | Aslan, Abdullah Tarik | |
dc.contributor.author | Vatansever, Cansel | |
dc.contributor.author | Falconer, Caitlin | |
dc.contributor.author | Dolapci, Istar | |
dc.contributor.author | Simsek, Funda | |
dc.contributor.author | Tulek, Necla | |
dc.contributor.author | Demirkaya, Hamiyet | |
dc.contributor.author | Menekse, Sirin | |
dc.contributor.author | Akalin, Halis | |
dc.contributor.author | Balkan, Ilker Inanc | |
dc.contributor.author | Aydin, Mehtap | |
dc.contributor.author | Tigen, Elif Tukenmez | |
dc.contributor.author | Demir, Safiye Koculu | |
dc.contributor.author | Kapmaz, Mahir | |
dc.contributor.author | Keske, Siran | |
dc.contributor.author | Dogan, Ozlem | |
dc.contributor.author | Arabaci, Cigdem | |
dc.contributor.author | Yagci, Serap | |
dc.contributor.author | Hazirolan, Gulsen | |
dc.contributor.author | Bakir, Veli Oguzalp | |
dc.contributor.author | Gonen, Mehmet | |
dc.contributor.author | Chatfield, Mark D. | |
dc.contributor.author | Forde, Brian | |
dc.contributor.author | Saltoglu, Nese | |
dc.contributor.author | Azap, Alpay | |
dc.contributor.author | Azap, Ozlem | |
dc.contributor.author | Akova, Murat | |
dc.contributor.author | Paterson, David L. | |
dc.contributor.author | Can, Fusun | |
dc.contributor.author | Ergonul, Onder | |
dc.contributor.pubmedID | 35301623 | en_US |
dc.date.accessioned | 2022-11-23T10:57:20Z | |
dc.date.available | 2022-11-23T10:57:20Z | |
dc.date.issued | 2022 | |
dc.description.abstract | A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam. | en_US |
dc.identifier.endpage | 847 | en_US |
dc.identifier.issn | 0934-9723 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.scopus | 2-s2.0-85126797654 | en_US |
dc.identifier.startpage | 841 | en_US |
dc.identifier.uri | http://hdl.handle.net/11727/8153 | |
dc.identifier.volume | 41 | en_US |
dc.identifier.wos | 000770200000001 | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.1007/s10096-022-04425-4 | en_US |
dc.relation.journal | EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | OXA-48 | en_US |
dc.subject | OXA-232 | en_US |
dc.subject | ST2096 | en_US |
dc.subject | Klebsiella pneumoniae | en_US |
dc.subject | Ceftazidime-avibactam | en_US |
dc.title | Characteristics And Outcomes Of Carbapenemase Harbouring Carbapenem-Resistant Klebsiella Spp. Bloodstream Infections: A Multicentre Prospective Cohort Study In An OXA-48 Endemic Setting | en_US |
dc.type | article | en_US |
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