Increased monocyte to HDL cholesterol ratio in vitamin B12 deficiency: Is it related to cardiometabolic risk?

dc.contributor.authorKirnap, Nazli Gulsoy
dc.contributor.pubmedID32639203en_US
dc.date.accessioned2022-08-09T08:19:50Z
dc.date.available2022-08-09T08:19:50Z
dc.date.issued2021
dc.description.abstractVitamin B12 deficiency may have indirect cardiovascular effects in addition to hematological and neuropsychiatric symptoms. It was shown that the monocyte count-to-high density lipoprotein cholesterol (HDL-C) ratio (MHR) is a novel cardiovascular marker. In this study, the aim was to evaluate whether MHR was high in patients with vitamin B12 deficiency and its relationship with cardiometabolic risk factors. The study included 128 patients diagnosed with vitamin B12 deficiency and 93 healthy controls. Patients with vitamin B12 deficiency had significantly higher systolic blood pressure (SBP), diastolic blood pressure (DBP), MHR, C-reactive protein (CRP) and uric acid levels compared with the controls (median 139 vs 115 mmHg, p < 0.001; 80 vs 70 mmHg, p < 0.001: 14.2 vs 9.5, p < 0.001: 10.2 vs 4 mg/dl p < 0.001: 6.68 vs 4.8 mg/dl, p < 0.001 respectively). The prevalence of left ventricular hypertrophy was higher in vitamin B12 deficiency group (43.8%) than the control group (8.6%) (p < 0.001). In vitamin B12 deficiency group, a positive correlation was detected between MHR and SBP, CRP and uric acid (p < 0.001 r:0.34, p < 0.001 r:0.30, p < 0.001 r:0.5, respectively) and a significant negative correlation was detected between MHR and T-CHOL, LDL, HDL and B12 (p < 0.001 r: -0.39, p < 0.001 r: -0.34, p < 0.001 r: -0.57, p < 0.04 r: -0.17, respectively). MHR was high in vitamin B12 deficiency group, and correlated with the cardiometabolic risk factors in this group, which were SBP, CRP, uric acid and HDL. In conclusion, MRH, which can be easily calculated in clinical practice, can be a useful marker to assess cardiovascular risk in patients with vitamin B12 deficiency.en_US
dc.identifier.endpage426en_US
dc.identifier.issn0300-9831en_US
dc.identifier.issue5-6en_US
dc.identifier.scopus2-s2.0-85089191784en_US
dc.identifier.startpage419en_US
dc.identifier.urihttp://hdl.handle.net/11727/7287
dc.identifier.volume9en_US
dc.identifier.wos000701997400006en_US
dc.language.isoengen_US
dc.relation.isversionof10.1024/0300-9831/a000668en_US
dc.relation.journalINTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectmonocyteen_US
dc.subjectvitamin B12en_US
dc.titleIncreased monocyte to HDL cholesterol ratio in vitamin B12 deficiency: Is it related to cardiometabolic risk?en_US
dc.typearticleen_US

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