Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus
dc.contributor.author | Aygun, Dursun | |
dc.contributor.author | Dere, Umit Akin | |
dc.contributor.author | Yildiz, Onur | |
dc.contributor.author | Temel, Yasin | |
dc.contributor.author | Kocabicak, Ersoy | |
dc.contributor.pubmedID | 30649828 | en_US |
dc.date.accessioned | 2020-12-29T12:49:28Z | |
dc.date.available | 2020-12-29T12:49:28Z | |
dc.date.issued | 2019 | |
dc.description.abstract | AIM: To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson's disease (PD) who underwent deep brain stimulation of the subthalamic nucleus. MATERIAL and METHODS: MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation. RESULTS: MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p<0.05). Tremor scores improved by 31.5% (L) and by 14.2% (R) (p<0.05), rigidity scores improved by 17.3% (L) and by 14.2% (R) (p<0.05) and bradykinesia scores improved by 20.6% (L) and by 11.5% (R) (p<0.05) from baseline. There was no significant difference between MLE and the number of microelectrodes used (p> 0.05). CONCLUSION: MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure. | en_US |
dc.identifier.endpage | 433 | en_US |
dc.identifier.issn | 1019-5149 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.scopus | 2-s2.0-85065868184 | en_US |
dc.identifier.startpage | 430 | en_US |
dc.identifier.uri | http://turkishneurosurgery.org.tr/pdf/pdf_JTN_2178.pdf | |
dc.identifier.uri | http://hdl.handle.net/11727/5294 | |
dc.identifier.volume | 29 | en_US |
dc.identifier.wos | 000466983900018 | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.5137/1019-5149.JTN.24348-18.3 | en_US |
dc.relation.journal | TURKISH NEUROSURGERY | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Parkinson's disease | en_US |
dc.subject | Subthalamic nucleus | en_US |
dc.subject | Deep brain stimulation | en_US |
dc.subject | Microelectrode recording | en_US |
dc.subject | Microlesion effect | en_US |
dc.title | Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus | en_US |
dc.type | article | en_US |