Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleus

dc.contributor.authorAygun, Dursun
dc.contributor.authorDere, Umit Akin
dc.contributor.authorYildiz, Onur
dc.contributor.authorTemel, Yasin
dc.contributor.authorKocabicak, Ersoy
dc.contributor.pubmedID30649828en_US
dc.date.accessioned2020-12-29T12:49:28Z
dc.date.available2020-12-29T12:49:28Z
dc.date.issued2019
dc.description.abstractAIM: To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson's disease (PD) who underwent deep brain stimulation of the subthalamic nucleus. MATERIAL and METHODS: MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation. RESULTS: MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p<0.05). Tremor scores improved by 31.5% (L) and by 14.2% (R) (p<0.05), rigidity scores improved by 17.3% (L) and by 14.2% (R) (p<0.05) and bradykinesia scores improved by 20.6% (L) and by 11.5% (R) (p<0.05) from baseline. There was no significant difference between MLE and the number of microelectrodes used (p> 0.05). CONCLUSION: MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.en_US
dc.identifier.endpage433en_US
dc.identifier.issn1019-5149en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85065868184en_US
dc.identifier.startpage430en_US
dc.identifier.urihttp://turkishneurosurgery.org.tr/pdf/pdf_JTN_2178.pdf
dc.identifier.urihttp://hdl.handle.net/11727/5294
dc.identifier.volume29en_US
dc.identifier.wos000466983900018en_US
dc.language.isoengen_US
dc.relation.isversionof10.5137/1019-5149.JTN.24348-18.3en_US
dc.relation.journalTURKISH NEUROSURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectParkinson's diseaseen_US
dc.subjectSubthalamic nucleusen_US
dc.subjectDeep brain stimulationen_US
dc.subjectMicroelectrode recordingen_US
dc.subjectMicrolesion effecten_US
dc.titleCharacterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients with Parkinson's Disease Undergoing Deep Brain Stimulation of the Subthalamic Nucleusen_US
dc.typearticleen_US

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