The Course of Renal Function After Radical Cystectomy with Ileal Conduit Diversion for Bladder Cancer

Abstract

Objective: We evaluated the course of the renal function and potential risk factors for renal deterioration in patients who had undergone radical cystectomy with ileal conduit diversion.

Materials and Methods: A retrospective study evaluated 121 patients, including 114 male and 7 female who underwent radical cystectomy with ileal conduit diversion. Estimated glomerular filtration rate (eGFR) was calculated and postoperative changes in renal function were reviewed. The clinical variables influencing renal function were evaluated.

Results: The median follow-up period was 35.6 months (range, 12.2 to 139.6 months). The mean eGFR was 78.37 +/- 27.58 mL/min/1.73 m(2) before surgery and 90.14 +/- 29.68 mL/min/1.73 m(2) at 5 years postoperatively. The comparison of preoperative eGFR and the last follow-up eGFR showed the no statistically significant difference (p=0.195). Statistical analysis showed that development of postoperative urinary tract obstruction and postoperative urinary tract infection were significant adverse factors (p=0.008, p=0.026, respectively).

Conclusion: Thirty two patients (53.3%) developed renal deterioration during the follow-up period. Development of urinary tract obstruction and urinary tract infection in the postoperative period were found to be significant adverse factors affecting renal function.