Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey

dc.contributor.authorKutuk, Meryem Ozlem
dc.contributor.authorTufan, Evren
dc.contributor.authorGokcen, Cem
dc.contributor.authorKilicaslan, Fethiye
dc.contributor.authorKaradag, Mehmet
dc.contributor.authorMutluer, Tuba
dc.contributor.authorYektas, Cigdem
dc.contributor.authorCoban, Nurdan
dc.contributor.authorKandemir, Hasan
dc.contributor.authorBuber, Ahmet
dc.contributor.authorCoskun, Seyma
dc.contributor.authorAcikbas, Ufuk
dc.contributor.authorGuler, Gulen
dc.contributor.authorTopal, Zehra
dc.contributor.authorCelik, Fatma
dc.contributor.authorAltintas, Ebru
dc.contributor.authorGiray, Asli
dc.contributor.authorAka, Yeliz
dc.contributor.authorKutuk, Ozgur
dc.contributor.orcID0000-0002-2918-7871en_US
dc.contributor.orcID0000-0001-9854-7220en_US
dc.contributor.orcID0000-0003-2735-4805en_US
dc.contributor.pubmedID32563959en_US
dc.contributor.researcherIDAAI-9626-2021en_US
dc.contributor.researcherIDAAH-1671-2019en_US
dc.contributor.researcherIDG-8832-2015en_US
dc.date.accessioned2021-05-30T07:13:30Z
dc.date.available2021-05-30T07:13:30Z
dc.date.issued2020
dc.description.abstractAutism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by impairments in communication and social interaction as well as restricted interests and repetitive behaviors. The pathogenesis of ASD is not completely understood, but a growing body of research has demonstrated that the immune response may be a contributing factor in the etiology and/or ontogeny of ASD. The aim of this study was to determine the expression levels of IL-1 beta, IL-1 alpha, IL-4, IL-6, IL-17, TNF-alpha and TGF-beta in peripheral blood mononuclear cells of children with ASD and healthy controls in order to determine the contributions of cytokines to ASD. Within the study timeframe, 195 children with ASDs (80.5% male) and 162 controls (73.6% male) were enrolled. Most children with ASD had a comorbid disorder (n = 114, 58.5%), with the most common diagnoses as Intellectual Developmental Disorder (IDD, n = 64, 32.8%) and ADHD (n = 64, 32.8%). The majority of children with ASD had severe autistic symptoms as evaluated via Childhood Autism Rating Scale (CARS, n = 130, 64.6%). The mean CARS score in the ASD sample was 40.8 (S.D. = 7.6). The patients with ASD were found to have significantly higher levels of IL-6 (p < 0.001) and significantly lower levels of IL-17 (p < 0.05, all Bonferroni corrected). Treatment tended to affect IL-4 levels. Lastly, discriminant function analysis (DFA) revealed that a combination of IL-6, IL-17 and IL-1 alpha correctly classified 56.6% of cases. Despite extensive immunological evidence suggesting immune system aberrations, further research is required to clarify the relationship between immune profiles and ASD symptoms.en_US
dc.identifier.issn1043-4666en_US
dc.identifier.scopus2-s2.0-85086567908en_US
dc.identifier.urihttp://hdl.handle.net/11727/5926
dc.identifier.volume133en_US
dc.identifier.wos000554002300029en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.cyto.2020.155152en_US
dc.relation.journalCYTOKINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutism Spectrum Disorderen_US
dc.subjectCytokinesen_US
dc.subjectImmune systemen_US
dc.subjectInflammationen_US
dc.titleCytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkeyen_US
dc.typearticleen_US

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