Role of New Biomarkers for Predicting Renal Scarring in Vesicoureteral Reflux: NGAL, KIM-1, And L-FABP

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dc.contributor.authorParmaksiz, Gonul
dc.contributor.authorNoyan, Aytul
dc.contributor.authorDursun, Hasan
dc.contributor.authorInce, Emine
dc.contributor.authorAnarat, Ruksan
dc.contributor.authorCengiz, Nurcan
dc.contributor.orcIDhttps://orcid.org/0000-0003-2373-1837en_US
dc.contributor.pubmedID26324091en_US
dc.contributor.researcherIDAAM-2935-2021en_US
dc.contributor.researcherIDAAD-5713-2021en_US
dc.contributor.researcherIDAAW-8783-2020en_US
dc.date.accessioned2023-07-20T08:15:16Z
dc.date.available2023-07-20T08:15:16Z
dc.date.issued2016
dc.description.abstractReflux nephropathy is the most serious complication of vesicoureteral reflux (VUR). The aim of this study was to assess the role of urinary levels of neutrophil-gelatinase-associated lipocalin (NGAL),kidney injury molecule-1 (KIM-1), and liver-type fatty-acid-binding protein (L-FABP) in the early diagnosis of reflux nephropathy in patients with VUR. This study assessed 123 patients with primary VUR and 30 healthy children as a control group. The children were divided into five groups: Group A, patients with VUR and renal parenchymal scarring (RPS); Group B, patients with VUR and without RPS; Group C, patients with RPS and resolved VUR; Group D, patients with resolved VUR and without RPS; Group E, healthy reference group. Median urinary NGAL (uNGAL)/Creatinine (Cr) was significantly higher in patients with than those without RPS and the control group (p = 0.0001). Median uKIM-1/Cr was similar in all groups (p = 0.417). Median uL-FABP/Cr was significantly higher in patients with RPS than in the reference group (p < 0.05). Urinary NGAL levels may be used as a noninvasive diagnostic marker for predicting renal scarring in reflux nephropathy.en_US
dc.identifier.endpage103en_US
dc.identifier.issn0931-041Xen_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84947494713en_US
dc.identifier.startpage97en_US
dc.identifier.urihttp://hdl.handle.net/11727/9999
dc.identifier.volume31en_US
dc.identifier.wos000365100500012en_US
dc.language.isoengen_US
dc.relation.isversionof10.1007/s00467-015-3194-3en_US
dc.relation.journalPEDIATRIC NEPHROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVesicoureteral refluxen_US
dc.subjectRenal parenchymal scarringen_US
dc.subjectNeutrophil-gelatinase-associated lipocalinen_US
dc.subjectKidney injury molecule-1en_US
dc.subjectLiver-type fatty-acid-binding proteinen_US
dc.titleRole of New Biomarkers for Predicting Renal Scarring in Vesicoureteral Reflux: NGAL, KIM-1, And L-FABPen_US
dc.typeArticleen_US

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