Association Between Familial Mediterranean Fever and Cachexia in Females

dc.contributor.authorDurmaz, Yunus
dc.contributor.authorIlhanli, Ilker
dc.contributor.authorCengiz, Ahmet Kivanc
dc.contributor.authorKaptanoglu, Ece
dc.contributor.authorOzkan Hasbek, Zekiye
dc.contributor.authorHizmetli, Sami
dc.contributor.pubmedID33758804en_US
dc.date.accessioned2021-04-16T06:10:17Z
dc.date.available2021-04-16T06:10:17Z
dc.date.issued2020
dc.description.abstractObjectives: This study aims to investigate the association between familial Mediterranean fever (FMF) and cachexia in females. Patients and methods: The study included 32 female FMF patients (median age 27.50 years; range, 18 to 50 years) and 30 female healthy controls (median age 32 years; range, 18 to 50 years). Patients were classified according to Tel-Hashomer criteria. Circumference of arm, waist, and thigh was recorded. Short form 36 (SF-36) and Multidimensional Assessment of Fatigue (MAF) scale were applied. Composition of the body was measured with dual X-ray absorption. Muscle strength was measured with an isokinetic dynamometer, and strength of hand grip was measured from dominant hand with a hand dynamometer. C-reactive protein, erythrocyte sedimentation rate, fibrinogen and serum creatinine kinase (CK) levels were recorded. Results: Body mass index was significantly higher in controls. Twelve patients and one control had cachexia. CK level was significantly higher in patients than controls. Mass of muscle without fat was significantly higher in patients than controls. Peak torque values of extension and flexion at the velocity of 60 degrees/second [Newton meter (Nm)], and value of total work during extension at the velocity of 240 degrees/second (Nm) in isokinetic measures were significantly higher in controls. MAF score was significantly higher in patients with cachexia than patients without cachexia where the subscale scores of SF-36, except the vitality score, were significantly lower in patients with cachexia. However, Tel-Hashomer score was significantly higher in patients with cachexia. Conclusion: This study pointed at a significant association between cachexia and FMF in females. Muscle endurance was not affected in FMF patients with cachexia; however, decreased muscle strength, impaired quality of life and increased fatigue were observed in these patients.en_US
dc.identifier.endpage485en_US
dc.identifier.issn2148-5046en_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85097810928en_US
dc.identifier.startpage477en_US
dc.identifier.urihttp://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=D6NKBFv8JhwKyuW8PIh&page=4&doc=187
dc.identifier.urihttp://hdl.handle.net/11727/5681
dc.identifier.volume35en_US
dc.identifier.wos000595829400003en_US
dc.language.isoengen_US
dc.relation.isversionof10.46497/ArchRheumatol.2020.7632en_US
dc.relation.journalARCHIVES OF RHEUMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCachexiaen_US
dc.subjectfamilial Mediterranean feveren_US
dc.subjectfatigueen_US
dc.subjectmuscle strengthen_US
dc.subjectquality of lifeen_US
dc.titleAssociation Between Familial Mediterranean Fever and Cachexia in Femalesen_US
dc.typearticleen_US

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