Does Cyclin E and P57(Kip2) Expression Have Prognostic and Survival Value in Colorectal Adenocarcinoma?

Abstract

Introduction: Colorectal cancer is still one of the main causes of cancer death in the world. There is a continous need for novel biomarkers for diagnose, treatment modalities and follow-up. Cyclin E and p57(KIP2) as the positive and negative regulators of cell cycle seem to be an important target for investigations. Materials and methods: In a retrospective setting, primary colorectal adenocarcinoma cases examined in Mustafa Kemal University, School of Medicine, Pathology Department between 2008-2015 were reviewed. Immunohistochemical expressions of cyclin E and p57(KIP2) in 80 pairs of colorectal carcinoma and adjacent normal mucosal tissues were evaluated and the findings were compared with clinicopathological parameters and survival time. Results: There were no statistically significant difference between two groups both in cyclin E and p57(KIP2) stained tissues (P>0.05). There were 40 (50%) patients in high-expression group and 40 (50%) patients in low-expression group for cyclin E. P57(KIP2) was negative in 55 (68.75%) patients and positive in 25 (31.75%) patients. There were no statistically significant relation between p57(KIP2) and cyclin E expressions with clinicopathologic parameters defined as age, gender, lymphovascular invasion, perineural invasion, depth of invasion, nodal involvement, emergency in operation, perforation before operation and overall survival except that there was significant relation between p57(KIP2) expression and histological grade (P=0.012). Conclusions: Immunohistochemical studies of cyclin E and p57(KIP2) should be performed with larger series of patients supported by more detailed technical research methods to be candidates as predictive markers for treatment modalities and prognostic factors.