Comparison of three different risk-stratification models for predicting lymph node involvement in endometrioid endometrial cancer clinically confined to the uterus
dc.contributor.author | Haberal, Ali | |
dc.contributor.author | Kocaman, Eda | |
dc.contributor.author | Dursun, Polat | |
dc.contributor.author | Ayhan, Ali | |
dc.contributor.author | Korkmaz, Vakkas | |
dc.contributor.author | Meydanli, Mehmet Mutlu | |
dc.contributor.author | Yalcin, Ibrahim | |
dc.contributor.author | Sari, Mustafa Erkan | |
dc.contributor.author | Sahin, Hanifi | |
dc.contributor.author | Gungor, Tayfun | |
dc.contributor.orcID | 0000-0002-1741-7035 | en_US |
dc.contributor.orcID | 0000-0002-1486-7209 | en_US |
dc.contributor.orcID | 0000-0002-7869-9662 | en_US |
dc.contributor.pubmedID | 29027396 | en_US |
dc.contributor.researcherID | AAI-9331-2021 | en_US |
dc.contributor.researcherID | AAJ-5802-2021 | en_US |
dc.date.accessioned | 2019-05-30T13:15:21Z | |
dc.date.available | 2019-05-30T13:15:21Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Objective: To compare the clinical validity of the Gynecologic Oncology Group-99 (GOG-99), the Mayo-modified and the European Society for Medical Oncology (ESMO)-modified criteria for predicting lymph node (LN) involvement in women with endometrioid endometrial cancer (EC) clinically confined to the uterus. Methods: A total of 625 consecutive women who underwent comprehensive surgical staging for endometrioid EC clinically confined to the uterus were divided into low- and high-risk groups according to the GOG-99, the Mayo-modified, and the ESMO-modified criteria. Lymphovascular space invasion is the cornerstone of risk stratification according to the ESMO-modified criteria. These 3 risk stratification models were compared in terms of predicting LN positivity. Results: Systematic LN dissection was achieved in all patients included in the study. LN involvement was detected in 70 (11.2%) patients. LN involvement was correctly estimated in 51 of 70 LN-positive patients according to the GOG-99 criteria (positive likelihood ratio [LR+], 3.3; negative likelihood ratio [LR-], 0.4), 64 of 70 LN-positive patients according to the ESMO-modified criteria (LR+, 2.5; LR-, 0.13) and 69 of the 70 LN-positive patients according to the Mayo-modified criteria (LR+, 2.2; LR-, 0.03). The area under curve of the Mayo-modified, the GOG-99 and the ESMO-modified criteria was 0.763, 0.753, and 0.780, respectively. Conclusion: The ESMO-modified classification seems to be the risk-stratification model that most accurately predicts LN involvement in endometrioid EC clinically confined to the uterus. However, the Mayo-modified classification may be an alternative model to achieve a precise balance between the desire to prevent over-treatment and the ability to diagnose LN involvement. | en_US |
dc.identifier.issn | 2005-0380 | |
dc.identifier.issue | 6 | en_US |
dc.identifier.scopus | 2-s2.0-85031499425 | en_US |
dc.identifier.uri | https://synapse.koreamed.org/Synapse/Data/PDFData/1114JGO/jgo-28-e78.pdf | |
dc.identifier.uri | http://hdl.handle.net/11727/3362 | |
dc.identifier.volume | 28 | en_US |
dc.identifier.wos | 000416673900007 | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.3802/jgo.2017.28.e78 | en_US |
dc.relation.journal | JOURNAL OF GYNECOLOGIC ONCOLOGY | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Carcinoma | en_US |
dc.subject | Endometrioid | en_US |
dc.subject | Endometrial Neoplasms | en_US |
dc.subject | Lymph Node | en_US |
dc.subject | Metastasis | en_US |
dc.title | Comparison of three different risk-stratification models for predicting lymph node involvement in endometrioid endometrial cancer clinically confined to the uterus | en_US |
dc.type | article | en_US |