Comparison of three different risk-stratification models for predicting lymph node involvement in endometrioid endometrial cancer clinically confined to the uterus

dc.contributor.authorHaberal, Ali
dc.contributor.authorKocaman, Eda
dc.contributor.authorDursun, Polat
dc.contributor.authorAyhan, Ali
dc.contributor.authorKorkmaz, Vakkas
dc.contributor.authorMeydanli, Mehmet Mutlu
dc.contributor.authorYalcin, Ibrahim
dc.contributor.authorSari, Mustafa Erkan
dc.contributor.authorSahin, Hanifi
dc.contributor.authorGungor, Tayfun
dc.contributor.orcID0000-0002-1741-7035en_US
dc.contributor.orcID0000-0002-1486-7209en_US
dc.contributor.orcID0000-0002-7869-9662en_US
dc.contributor.pubmedID29027396en_US
dc.contributor.researcherIDAAI-9331-2021en_US
dc.contributor.researcherIDAAJ-5802-2021en_US
dc.date.accessioned2019-05-30T13:15:21Z
dc.date.available2019-05-30T13:15:21Z
dc.date.issued2017
dc.description.abstractObjective: To compare the clinical validity of the Gynecologic Oncology Group-99 (GOG-99), the Mayo-modified and the European Society for Medical Oncology (ESMO)-modified criteria for predicting lymph node (LN) involvement in women with endometrioid endometrial cancer (EC) clinically confined to the uterus. Methods: A total of 625 consecutive women who underwent comprehensive surgical staging for endometrioid EC clinically confined to the uterus were divided into low- and high-risk groups according to the GOG-99, the Mayo-modified, and the ESMO-modified criteria. Lymphovascular space invasion is the cornerstone of risk stratification according to the ESMO-modified criteria. These 3 risk stratification models were compared in terms of predicting LN positivity. Results: Systematic LN dissection was achieved in all patients included in the study. LN involvement was detected in 70 (11.2%) patients. LN involvement was correctly estimated in 51 of 70 LN-positive patients according to the GOG-99 criteria (positive likelihood ratio [LR+], 3.3; negative likelihood ratio [LR-], 0.4), 64 of 70 LN-positive patients according to the ESMO-modified criteria (LR+, 2.5; LR-, 0.13) and 69 of the 70 LN-positive patients according to the Mayo-modified criteria (LR+, 2.2; LR-, 0.03). The area under curve of the Mayo-modified, the GOG-99 and the ESMO-modified criteria was 0.763, 0.753, and 0.780, respectively. Conclusion: The ESMO-modified classification seems to be the risk-stratification model that most accurately predicts LN involvement in endometrioid EC clinically confined to the uterus. However, the Mayo-modified classification may be an alternative model to achieve a precise balance between the desire to prevent over-treatment and the ability to diagnose LN involvement.en_US
dc.identifier.issn2005-0380
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85031499425en_US
dc.identifier.urihttps://synapse.koreamed.org/Synapse/Data/PDFData/1114JGO/jgo-28-e78.pdf
dc.identifier.urihttp://hdl.handle.net/11727/3362
dc.identifier.volume28en_US
dc.identifier.wos000416673900007en_US
dc.language.isoengen_US
dc.relation.isversionof10.3802/jgo.2017.28.e78en_US
dc.relation.journalJOURNAL OF GYNECOLOGIC ONCOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarcinomaen_US
dc.subjectEndometrioiden_US
dc.subjectEndometrial Neoplasmsen_US
dc.subjectLymph Nodeen_US
dc.subjectMetastasisen_US
dc.titleComparison of three different risk-stratification models for predicting lymph node involvement in endometrioid endometrial cancer clinically confined to the uterusen_US
dc.typearticleen_US

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