Does Renal Function Affect Gadolinium Deposition in the Brain?

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dc.contributor.authorRahatli, Feride Kural
dc.contributor.authorDonmez, Fuldem Yildirim
dc.contributor.authorKibaroglu, Seda
dc.contributor.authorKesim, Cagri
dc.contributor.authorHaberal, Kemal Murat
dc.contributor.authorTurnaoglu, Hale
dc.contributor.authorAgildere, Ahmet Muhtesem
dc.contributor.orcID0000-0002-4226-4034en_US
dc.contributor.orcID0000-0003-4502-106Xen_US
dc.contributor.orcID0000-0002-3964-268Xen_US
dc.contributor.orcID0000-0002-8964-291Xen_US
dc.contributor.orcID0000-0002-8211-4065en_US
dc.contributor.orcID0000-0002-0781-0036en_US
dc.contributor.orcID0000-0003-4223-7017en_US
dc.contributor.pubmedID29857863en_US
dc.contributor.researcherIDAAL-9808-2021en_US
dc.contributor.researcherIDAAE-5528-2021en_US
dc.contributor.researcherIDAAJ-2956-2021en_US
dc.contributor.researcherIDAAD-5996-2021en_US
dc.contributor.researcherIDR-9398-2019en_US
dc.contributor.researcherIDAAK-8242-2021en_US
dc.contributor.researcherIDAAB-5802-2020en_US
dc.date.accessioned2023-05-10T08:26:10Z
dc.date.available2023-05-10T08:26:10Z
dc.date.issued2018
dc.description.abstractObjective: Was to compare T1 signal intensity ratios of dentate nucleus to cerebellar white matter (DN/cerebellum), dentate nucleus to pons (DN/pons) and globus pallidus to thalamus (GP/thalamus) in patients with normal renal function and in patients on chronic hemodialysis. To find out if renal function affects the deposition of gadolinium in brain after administration of linear gadolinium based contrast agents (GBCA). Methods: Seventy eight contrast enhanced brain MRIs (Magnetic Resonance Imaging) with linear GBCA of 13 patients on chronic hemodialysis and 13 patients with normal renal function retrospectively evaluated. The DN/ pons, DN/cerebellum and GP/thalamus signal intensity ratios were measured from each brain MRI on unenhanced axial T1 weighted images. Results: In hemodialysis group statistically significant increase in the signal intensity ratios of DN/pons, DN/ cerebellum and GP/thalamus were found between the first and the last brain MRIs (p = .001). The increase in the signal intensity ratios of DN/pons, DN/cerebellum and GP/thalamus between the first and the last brain MRIs in control group were not significant (p > 0.05). The signal intensity increase in DN and globus pallidus were significantly higher in hemodialysis group than control group (p < 0.05). Conclusions: Patients on hemodialysis had significantly higher DN and GP signal intensity increase compared to the patients with normal renal function. Renal function affects the rate of gadolinium deposition in the brain after administration of linear GBCA.en_US
dc.identifier.endpage37en_US
dc.identifier.issn0720-048Xen_US
dc.identifier.startpage33en_US
dc.identifier.urihttp://hdl.handle.net/11727/8956
dc.identifier.volume104en_US
dc.identifier.wos000433413200006en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.ejrad.2018.04.017en_US
dc.relation.journalEUROPEAN JOURNAL OF RADIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemodialysisen_US
dc.subjectGadolinium based contrast agenten_US
dc.subjectBrain MRIen_US
dc.subjectDentate nucleusen_US
dc.subjectGlobus pallidusen_US
dc.titleDoes Renal Function Affect Gadolinium Deposition in the Brain?en_US
dc.typearticleen_US

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