Metformin Decreases Thyroid Volume and Nodule Size in Subjects with Insulin Resistance: A Preliminary Study

dc.contributor.authorAnil, Cuneyd
dc.contributor.authorKut, Altug
dc.contributor.authorAtesagaoglu, Berna
dc.contributor.authorNar, Asli
dc.contributor.authorTutuncu, Neslihan Bascil
dc.contributor.authorGursoy, Alptekin
dc.contributor.pubmedID26618447en_US
dc.date.accessioned2019-09-12T08:54:21Z
dc.date.available2019-09-12T08:54:21Z
dc.date.issued2016
dc.description.abstractObjective: The aim of this study was to investigate the effects of metformin on thyroid volume and nodule size. Subjects and Methods: Prospective data were gathered on 100 newly diagnosed subjects with insulin resistance (68 female, 32 male) between August 2008 and May 2010. Each subject followed a standard diet and exercise program, and received 1,700 mg/day of metformin therapy for 6 months. The height, weight, waist circumference (WC) and thyroid hormone levels of each subject were measured. Additionally, the dimensions of the thyroid lobes and maximum diameter of each thyroid nodule were determined by ultrasonography. BMI and thyroid volumes were also calculated. Insulin resistance was estimated by homeostasis model assessment. All these parameters were measured at the beginning and at the end of the treatment period. Results: BMI and WC decreased significantly after metformin therapy (34.5 +/- 5.1 vs. 32.7 +/- 4.8, p < 0.0001, and 106.3 +/- 11.8 vs. 101.8 +/- 19.0 cm, p = 0.008, respectively). Insulin resistance also decreased after metformin therapy (4.5 +/- 1.9 vs. 2.9 +/- 1.7, p < 0.0001). The mean thyroid volume (22.5 +/- 11.2 vs. 20.3 +/- 10.4 ml, p < 0.0001) and mean thyroid nodule size (12.9 +/- 7.6 vs. 11.7 +/- 7.2 mm, p < 0.0001) also decreased after treatment. Conclusion: In subjects with insulin resistance, metformin therapy significantly decreased thyroid volume and nodule size. (C) 2015 S. Karger AG, Baselen_US
dc.identifier.endpage236en_US
dc.identifier.issn1011-7571
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84950123490en_US
dc.identifier.startpage233en_US
dc.identifier.urihttps://www.karger.com/Article/Pdf/442821
dc.identifier.urihttp://hdl.handle.net/11727/3901
dc.identifier.volume25en_US
dc.identifier.wos000375783500005en_US
dc.language.isoengen_US
dc.relation.isversionof10.1159/000442821en_US
dc.relation.journalMEDICAL PRINCIPLES AND PRACTICEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInsulin resistanceen_US
dc.subjectMetforminen_US
dc.subjectThyroid volumeen_US
dc.subjectNodule sizeen_US
dc.titleMetformin Decreases Thyroid Volume and Nodule Size in Subjects with Insulin Resistance: A Preliminary Studyen_US
dc.typearticleen_US

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