Evaluation of Dynapenia and Sarcopenia and Their Associations With Serum Insulin-Like Growth Factor-1 Levels in Renal Transplant Recipients

dc.contributor.authorYildirim, Saliha
dc.contributor.authorColak, Turan
dc.contributor.authorBayraktar, Nilufer
dc.contributor.authorSezer, Siren
dc.contributor.orcIDhttps://orcid.org/0000-0002-2693-1167en_US
dc.contributor.orcIDhttps://orcid.org/0000-0002-8372-7840en_US
dc.contributor.orcIDhttps://orcid.org/0000-0002-7886-3688en_US
dc.contributor.orcIDhttps://orcid.org/0000-0002-7326-8388en_US
dc.contributor.pubmedID34716090en_US
dc.contributor.researcherIDAAJ-8554-2021en_US
dc.contributor.researcherIDY-8758-2018en_US
dc.date.accessioned2022-12-21T08:35:19Z
dc.date.available2022-12-21T08:35:19Z
dc.date.issued2022
dc.description.abstractObjectives: Dynapenia and sarcopenia are related to increased morbidity and mortality in the general population. Chronic kidney disease (CKD) causes sarcopenia and dynapenia with different mechanisms. The aim of this study is to compare the muscle parameters in renal transplant recipients to CKD patients and patients without kidney disease and assess their associations with serum insulin-like growth factor-1 (IGF-1) levels. Method: In total, 120 renal transplant recipients (mean age: 40.4 +/- 10.5 years), 60 CKD patients (mean age: 41.9 +/- 11.4 years), and 60 control subjects with normal kidney function (mean age: 38.8 +/- 9.9 years) were enrolled. Body mass index, hand grip strength, bioelectrical impedance analysis, 6-minute walking test, and serum IGF-1 level were measured and compared between groups. Muscle parameters were evaluated according to The Foundation for the National Institutes of Health Biomarkers Consortium Sarcopenia Project criteria. Results: IGF-1 levels were highest in the renal transplantation group and lowest in the control group (P = .029). In total, 12.5% of patients in the renal transplantation group (13.3% overweight, 20% obese), 11.6% in the CKD group, and 1.6% in the control group had dynapenia (P = .015). In addition, 8.3% of patients in the CKD group, 3.3% in the renal transplantation group (50% overweight), and none of the patients in the control group had sarcopenia (P = .054). In multivariate analyses, muscle strength was associated with IGF-1 levels in renal transplant recipients (beta = 2.314, t = 3.456, P = .001). Conclusions: Serum IGF-1 is closely associated with muscle strength in renal transplant recipients. The negative effects of CKD on muscle system cannot be completely resolved with renal transplantation. Sarcopenic obesity and dynapenic obesity need special attention and therefore body mass index cannot be used as the only parameter to evaluate frailty in renal transplant recipients. (C) 2021 by the National Kidney Foundation, Inc. All rights reserved.en_US
dc.identifier.endpage362en_US
dc.identifier.issn1051-2276en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85118324406en_US
dc.identifier.startpage354en_US
dc.identifier.urihttp://hdl.handle.net/11727/8396
dc.identifier.volume32en_US
dc.identifier.wos000831268500015en_US
dc.language.isoengen_US
dc.relation.isversionof10.1053/j.jrn.2021.08.013en_US
dc.relation.journalJOURNAL OF RENAL NUTRITIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEvaluation of Dynapenia and Sarcopenia and Their Associations With Serum Insulin-Like Growth Factor-1 Levels in Renal Transplant Recipientsen_US
dc.typearticleen_US

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