The relationship between fibrosis and nodule structure and esophageal varices

dc.contributor.authorCosar, Arif Mansur
dc.contributor.authorYakar, Tolga
dc.contributor.authorSerin, Ender
dc.contributor.authorOzer, Birol
dc.contributor.authorKayaselcuk, Fazilet
dc.contributor.pubmedID31290750en_US
dc.date.accessioned2020-12-24T16:13:25Z
dc.date.available2020-12-24T16:13:25Z
dc.date.issued2019
dc.description.abstractBackground/Aims: The aim of the present study was to evaluate the histopathological findings of cirrhosis together with clinical and laboratory parameters, and to investigate their relationship with esophageal varices that are portal hypertension findings. Materials and Methods: A total of 67 (42 male and 25 female) patients who were diagnosed with cirrhosis were included in the study. The mean age of the patients was 51.6 +/- 19.0 (1-81) years. The biopsy specimens of the patients were graded in terms of fibrosis, nodularity, loss of portal area, central venous loss, inflammation, and steatosis. The spleen sizes were graded ultrasonographically, and the esophageal varices were graded endoscopically. Results: In the multivariate regression analysis, there was a correlation between the advanced disease stage (Child-Pugh score odds ratio (OR): 1.47, 95% confidence interval (CI): 1.018-2.121, p=0.040), presence of micronodularity (OR: 0.318, 95% CI: 0.120-0.842, p=0.021), grade of central venous loss (OR: 5.231, 95% CI: 1.132-24.176, p=0.034), and presence of esophageal varicose veins. Conclusion: Although thrombocytopenia and splenomegaly may predict the presence of large esophageal varices, cirrhosis histopathology is the main factor in the presence of varices.en_US
dc.identifier.endpage629en_US
dc.identifier.issn1300-4948en_US
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85069053041en_US
dc.identifier.startpage624en_US
dc.identifier.urihttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6629287&blobtype=pdf
dc.identifier.urihttp://hdl.handle.net/11727/5185
dc.identifier.volume30en_US
dc.identifier.wos000474444300007en_US
dc.language.isoengen_US
dc.relation.isversionof10.5152/tjg.2019.18665en_US
dc.relation.journalTURKISH JOURNAL OF GASTROENTEROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCirrhosisen_US
dc.subjecthistopathologyen_US
dc.subjectportal hypertensionen_US
dc.subjectesophageal varicesen_US
dc.titleThe relationship between fibrosis and nodule structure and esophageal varicesen_US
dc.typearticleen_US

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