Coexistence of guanidinoacetate methyltransferase (GAMT) deficiency and neuroleptic malignant syndrome without creatine kinase elevation

dc.contributor.authorAyanoglu, Muge
dc.contributor.authorKorgali, Elif
dc.contributor.authorSezer, Taner
dc.contributor.authorAydin, Halil Ibrahim
dc.contributor.authorSonmez, Fatma Mujgan
dc.contributor.orcID0000-0002-2278-1827en_US
dc.contributor.orcID0000-0001-7994-4394en_US
dc.contributor.pubmedID32173091en_US
dc.contributor.researcherIDAAJ-5931-2021en_US
dc.date.accessioned2021-06-21T06:48:36Z
dc.date.available2021-06-21T06:48:36Z
dc.date.issued2020
dc.description.abstractWe describe the first child with guanidinoacetate methyltransferase (GAMT) deficiency who developed neuroleptic malignant syndrome (NMS) after the treatment of risperidone without elevated creatine kinase (CK) levels. The patient presented with lethargy, hyperthermia, generalized tremor and rigidity with normal serum CK levels. After cessation of risperidone and adding clonezepam to the supportive treatment, symptoms of NMS were ameliorated. We conclude that although serum CK elevation is a useful indicator for the early detection of NMS, normal serum CK levels may be seen during the NMS course in the presence of GAMT deficiency. (C) 2020 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.endpage420en_US
dc.identifier.issn0387-7604en_US
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85081701781en_US
dc.identifier.startpage418en_US
dc.identifier.urihttp://hdl.handle.net/11727/6121
dc.identifier.volume42en_US
dc.identifier.wos000527287200008en_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/j.braindev.2020.02.001en_US
dc.relation.journalBRAIN & DEVELOPMENTen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGuanidinoacetate methyltransferase (GAMT) deficiencyen_US
dc.subjectNeuroleptic malignant syndromeen_US
dc.subjectNormal creatine kinase levelsen_US
dc.titleCoexistence of guanidinoacetate methyltransferase (GAMT) deficiency and neuroleptic malignant syndrome without creatine kinase elevationen_US
dc.typearticleen_US

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