Effect of rosuvastatin on spatial learning, memory, and anxiety-like behaviour in ovariectomized rats

dc.contributor.authorEmre-Aydingoz, Selda
dc.contributor.authorLux, Karl Michael
dc.contributor.authorEfe, Oguzhan Ekin
dc.contributor.authorTopcu, Deniz Ilhan
dc.contributor.authorErdem, Saban Remzi
dc.contributor.orcID0000-0001-7823-7620en_US
dc.contributor.orcID0000-0002-3243-7843en_US
dc.contributor.orcID0000-0002-1219-6368en_US
dc.contributor.pubmedID35993621en_US
dc.contributor.researcherIDABA-4291-2020en_US
dc.contributor.researcherIDW-7908-2019en_US
dc.contributor.researcherIDE-3717-2019en_US
dc.date.accessioned2022-12-23T10:27:07Z
dc.date.available2022-12-23T10:27:07Z
dc.date.issued2022
dc.description.abstractThe effect of rosuvastatin (Ros) on cognitive function and anxiety-like behaviour in ovariectomized rats were evaluated. Eighteen female Wistar rats (218-310g, 6-8 months old) were allocated into sham (n = 6), ovariectomy (Ovx, n = 6) or Ovx + Ros (up to eighth week n = 6, then n = 4) groups. Ros was administered at 20 mg/kg/day by oral gavage for 12 weeks. Behavioural tests were performed at 4, 8 and 12 weeks following Ovx. At 12weeks, Ovx group had significantly longer escape latency than the sham group at the first day of the four-day training period of the Morris Water Maze test (p < .01). In the Elevated Plus Maze test, Ovx group spent significantly more time in the closed arms than the sham group (p < .01), and this anxiety-like behavioural effect of Ovx was prevented by 12-weeks Ros treatment (p < .05). In conclusion, Ros prevents memory deficit and anxiety-like behaviour in the ovariectomized rats, a model for human surgical menopause.en_US
dc.identifier.issn0144-3615en_US
dc.identifier.scopus2-s2.0-85136492568en_US
dc.identifier.urihttp://hdl.handle.net/11727/8428
dc.identifier.wos000843864300001en_US
dc.language.isoengen_US
dc.relation.isversionof10.1080/01443615.2022.2112024en_US
dc.relation.journalJOURNAL OF OBSTETRICS AND GYNAECOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnxietyen_US
dc.subjectcognitionen_US
dc.subjectsurgical menopauseen_US
dc.subjectovariectomyen_US
dc.subjectratsen_US
dc.subjectrosuvastatinen_US
dc.titleEffect of rosuvastatin on spatial learning, memory, and anxiety-like behaviour in ovariectomized ratsen_US
dc.typearticleen_US

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