Effect of rosuvastatin on spatial learning, memory, and anxiety-like behaviour in ovariectomized rats
dc.contributor.author | Emre-Aydingoz, Selda | |
dc.contributor.author | Lux, Karl Michael | |
dc.contributor.author | Efe, Oguzhan Ekin | |
dc.contributor.author | Topcu, Deniz Ilhan | |
dc.contributor.author | Erdem, Saban Remzi | |
dc.contributor.orcID | 0000-0001-7823-7620 | en_US |
dc.contributor.orcID | 0000-0002-3243-7843 | en_US |
dc.contributor.orcID | 0000-0002-1219-6368 | en_US |
dc.contributor.pubmedID | 35993621 | en_US |
dc.contributor.researcherID | ABA-4291-2020 | en_US |
dc.contributor.researcherID | W-7908-2019 | en_US |
dc.contributor.researcherID | E-3717-2019 | en_US |
dc.date.accessioned | 2022-12-23T10:27:07Z | |
dc.date.available | 2022-12-23T10:27:07Z | |
dc.date.issued | 2022 | |
dc.description.abstract | The effect of rosuvastatin (Ros) on cognitive function and anxiety-like behaviour in ovariectomized rats were evaluated. Eighteen female Wistar rats (218-310g, 6-8 months old) were allocated into sham (n = 6), ovariectomy (Ovx, n = 6) or Ovx + Ros (up to eighth week n = 6, then n = 4) groups. Ros was administered at 20 mg/kg/day by oral gavage for 12 weeks. Behavioural tests were performed at 4, 8 and 12 weeks following Ovx. At 12weeks, Ovx group had significantly longer escape latency than the sham group at the first day of the four-day training period of the Morris Water Maze test (p < .01). In the Elevated Plus Maze test, Ovx group spent significantly more time in the closed arms than the sham group (p < .01), and this anxiety-like behavioural effect of Ovx was prevented by 12-weeks Ros treatment (p < .05). In conclusion, Ros prevents memory deficit and anxiety-like behaviour in the ovariectomized rats, a model for human surgical menopause. | en_US |
dc.identifier.issn | 0144-3615 | en_US |
dc.identifier.scopus | 2-s2.0-85136492568 | en_US |
dc.identifier.uri | http://hdl.handle.net/11727/8428 | |
dc.identifier.wos | 000843864300001 | en_US |
dc.language.iso | eng | en_US |
dc.relation.isversionof | 10.1080/01443615.2022.2112024 | en_US |
dc.relation.journal | JOURNAL OF OBSTETRICS AND GYNAECOLOGY | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Anxiety | en_US |
dc.subject | cognition | en_US |
dc.subject | surgical menopause | en_US |
dc.subject | ovariectomy | en_US |
dc.subject | rats | en_US |
dc.subject | rosuvastatin | en_US |
dc.title | Effect of rosuvastatin on spatial learning, memory, and anxiety-like behaviour in ovariectomized rats | en_US |
dc.type | article | en_US |
Files
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.71 KB
- Format:
- Item-specific license agreed upon to submission
- Description: