Evaluation of contact sensitivity in patients with psoriasis

Abstract

Objective: Psoriasis is a chronic, immune-mediated,relapsing inflammatory disease which mixed Th1 and Th17 cytokines play role in. Psoriasis can be triggered by physical trauma, contact with chemicals, burns, environmental factors such as ultraviolet and Köbner-ization. This study aimed to determine the contact sensitivity in psoriatic patient and compare from the normal population. Material and Methods: A hundred clinically and/or histopatho-logically diagnosed, other than erithrodermic and pustular types and older than 18 years old psoriatic patients were enrolled into the study. For control group; older than 18 years old, voluntary, without psoriasis and contact dermatitits 100 patients were enrolled. European Standard Series skin patch system, IQ Chamber test materials were applied on unlesional skin of cases in both greoups. Analyses were performed using SPSS for Windows Version 20.0 program. Results: Sixty-one of 100 psoriasis patients, 58 of 100 control group patients were allerjic to at least one allergen. This difference between the groups wasn t found statistically meaningful. There was no correlation between patch tests sensitivity and disease severity, disease or lesion duration or psoriasis types. Statistically meaningful correlation was found between contact sensitivity and genital and upper extremity involvement. Nickel sulfate was the most common allergen in both groups. Conclusion: Although allergic contact sensitivity found in psoriatic group not different from the control group,especially upper extremity and genital involvement,contact sensitivity can play the role in provocation and progression of psoriasis. Copyright © 2018 by Türkiye Klinikleri.